Navigation Links
Laparoscopic Surgeons Develop Fluorescent Light Technique to Improve Pancreatic Cancer Detection
Date:10/24/2011

SAN FRANCISCO, Oct. 24, 2011 /PRNewswire-USNewswire/ -- More than 80 percent of people with pancreatic cancer are diagnosed after the cancer has metastasized, and by then the prognosis for long-term survival is dismal.  However, surgeons and scientists at the University of California-San Diego (UCSD) are developing a laparoscopic technique that uses fluorescent light to improve pancreatic cancer staging and treatment.  Their findings were presented today at the 2011 Clinical Congress of the American College of Surgeons.

The UCSD researchers compared a standard xenon laparoscope with a laparoscope using a light emitting diode (LED) source.  Surgeons took two antibodies that are commonly expressed by pancreatic cancer and tagged them with a fluorescent marker, thus, making the cancerous tumors "light up" in colors of bright green or red, reported study leaders, Michael Bouvet, MD, FACS, and Robert M. Hoffman, Ph.D., both UCSD professors of surgery.

The surgeons and scientists then administered fluorescent antibodies into six-week old female mice.  The researchers were able to see primary and metastatic tumors more vividly with the LED light, at a sensitivity rate of 96 percent, than with traditional laparoscopy, which had a sensitivity rate of 40 percent.  Moreover, fluorescent laparoscopy rendered fewer false positives than traditional laparoscopy, and the researchers were able to clearly see the surrounding anatomy in the abdominal cavity of the mice.  Fluorescent laparoscopy was also sensitive enough to illuminate metastatic lesions smaller than one millimeter, which are not visible with a standard laparoscope.

"Laparoscopy is used for staging in patients with cancer, often before we make a big incision," said Dr. Bouvet.  "Now, we've made it even better with the LED light source.  We modified it so you can see both the normal background of the anatomy plus the fluorescent tumor signal at the same time.  We were able to perform LED fluorescence laparoscopy in mice with small, three millimeter laparoscopes."

The fluorescent marker did not show evidence of toxicity or side effects in the mice.  The combination of LED light and fluorescent markers for malignant tumors could potentially sharpen how surgeons detect and treat pancreatic cancer in human patients.  If patients have received the fluorescent antibodies prior to an operation, the surgeon can insert the LED laparoscope through a small incision and determine if the cancer has metastasized to other areas of the abdomen.  "If it has spread, then we can biopsy those areas and better determine if the best initial treatment should be chemotherapy and save the patient the large incision," Dr. Bouvet said.  "If there's no or limited metastases, then we can more completely remove the primary and metastatic tumors because we can see the edges better.  We're hoping for a lower rate of local recurrence."

Once the cancerous tumors are illuminated, Dr. Bouvet explains, the surgeons are able to more precisely remove the tumor and any surrounding malignant tissue without injuring the aorta and other nearby blood vessels.  Furthermore, another potential application for this technique could involve medically treating pancreatic cancer: "You could tag a specific drug or isotope to target tumor cells.  Since the fluorescent antibodies bind specifically to cancer cells, you could deliver certain payloads of drugs that would kill the cancer cells more effectively," Dr. Bouvet said.

The technique could also be applied to staging and treating colon cancer, which often is expressed through the same antibodies as pancreatic cancer and treated with the same laparoscopic technology.  Within the next four years, Dr. Bouvet plans to work with OncoFluor, Inc., a biotech company that develops fluorescent compounds for malignant tumors, on securing FDA approval for clinical trials of the fluorescent antibodies in humans.

Other members of the research team included Cristina Angela Metildi Raimo, MD; Sharmeela Kaushal, Ph.D.; Chanae Hardamon, BSc, Hop Tran Cao, MD; Cynthia S. Snyder, MD; George A. Luiken, MD; and Mark A. Talamini, MD, FACS, all from the University of California-San Diego, San Diego, CA;  OncoFluor, Inc., San Diego, CA; and AntiCancer, Inc., San Diego, CA.

NOTE: The UCSD research team worked with AntiCancer, Inc. on the mouse model and with laparoscope technicians at Stryker Corporation.  The research is funded by a five-year grant to UCSD and AntiCancer, Inc. from the National Cancer Institute.


'/>"/>
SOURCE American College of Surgeons
Copyright©2010 PR Newswire.
All rights reserved

Related medicine technology :

1. Surgeons Find That Laparoscopic Banding Procedure Helps Overweight Adolescents Lose Weight and Improve Health
2. Internationally Renowned Bariatric and Laparoscopic Surgeons To Meet in San Diego
3. CareFusion Signs Exclusive Partnership Agreement With Minimally Invasive Devices to Distribute FloShield Laparoscopic Technology
4. PolyTouch Medical Ltd. Receives FDA Clearance to Commercialize PatchAssist(TM) - an Innovative Surgical Instrument Intended to Facilitate the Delivery of Soft Tissue Prosthetics During the Laparoscopic Repair of Soft Tissue Defects
5. Steerable Technologix LLC Announces Release of SurgiSteer Laparoscopic Instruments
6. Simbionix and USF Receive Grant to Support Development of Laparoscopic Hysterectomy Simulation
7. Solos Endoscopy, Inc. Strengthens Current Line of Laparoscopic Instruments
8. Dr. Andreas Kuthe Performs First Laparoscopic Procedures Using Cardicas Microcutter XPRESS™ 30 Surgical Cutting and Stapling Device
9. New Micro Laparoscopic Instruments for the Bariatric Surgery Allow for Less Scarring and Pain than Ever Before Possible
10. Ethicon Endo-Surgery Introduces First Powered Endocutter with Enhanced System-Wide Compression and Stability, Allowing Surgeons Greater Control in Laparoscopic Surgery
11. Terumo Heart to Announce Results of European Clinical Trial of DuraHeart(TM) LVAS at European Association of Cardiothoracic Surgeons Meeting in September
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/18/2017)... , January 18, 2017 According to a new report ... Application: Global Opportunity Analysis and Industry Forecast, 2014 - 2022," the global polyphenol ... $1,127 million by 2022, growing at a CAGR of 8.26% from 2016 to ... of revenue. Continue Reading ... ...
(Date:1/18/2017)... GREENWOOD VILLAGE, Colo. , Jan. 18, 2017 /PRNewswire/ ... an independent chain of pharmacies based in ... Safe Rx™ Locking Prescription Vials (LPVs) in selected Good Day ... abuse now have a cost-effective alternative for secure storage," ... Safe Rx.  "For less than the price of a ...
(Date:1/18/2017)... , Jan. 18, 2017   Seno Medical ... of diagnosing breast cancer through the development of an ... Steve Miller as SVP of Engineering. Mr. ... Realization at FUJIFILM SonoSite, with headquarters in ... majority of his 30-year career to the development of ...
Breaking Medicine Technology:
(Date:1/18/2017)... Mich. USA; SAN JOSE, Calif, USA; and SHANGHAI, China – ... ... (PRWEB) January 18, 2017 -- Global public health organization ... reduce arsenic V (pentavalent arsenic) to NSF/ANSI 53: Drinking Water ... drinking water treatment units. This certification verifies that MicroCeramics’ NanoNose ...
(Date:1/18/2017)... ... ... The V Foundation for Cancer Research, a top-rated cancer research charity, announced ... to compete in the Boston Marathon on April 17. From first-time participants to ... marathon to join Team V and support the Foundation’s mission to declare victory over ...
(Date:1/18/2017)... ... 2017 , ... PrideStaff, a national, franchised staffing organization ... Turner Pizarro, was recently featured on Fox Business Network's Worldwide Business with kathy ... leaders from across the globe, provides viewers an opportunity to find solutions to ...
(Date:1/18/2017)... ... January 18, 2017 , ... Park Agencies Insurance ... services to families and business owners in the greater Kansas City area, is ... developmental disabilities. , The Lakemary Center is a comprehensive educational resource center that ...
(Date:1/18/2017)... ... January 18, 2017 , ... Dr. Farhan Qureshi is an esteemed dentist ... His modern dental practice has two convenient office locations in Alexandria and Arlington, Virginia. ... Dentist for the Alexandria area. This award confirms the fact that Dr. Qureshi’s ...
Breaking Medicine News(10 mins):