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Landmark Study in The Lancet Oncology Shows Capecitabine (Xeloda(R)) Combination Therapy Reduces Early Breast Cancer Recurrence
Date:11/11/2009

ncouraged by this analysis, which demonstrates that adding capecitabine to the chemotherapy regimen in the early stages of breast cancer may prevent the cancer coming back," he added.

Breast cancer is the second most common cancer in the world and the most common cancer among women.[2] There are 1.1 million new cases of female breast cancer each year worldwide.[2] Despite recent advances, there is still an unmet need in the treatment and management of early breast cancer with relapse occurring in approximately 30% of patients, depending on individual risk factors, even after chemotherapy.[3]

Notes to editors:

About the FinXX study

The study, led by the Finnish Breast Cancer Group, was a large open-label, two-arm, randomised multicentre phase III study in women with early breast cancer. 1,500 patients in Finland and Sweden with no distant metastases who had an intermediate to high risk of recurrence within five years from the time of diagnosis, were recruited to the study.

    - The primary objective of the study was to compare the
      recurrence-free survival of patients receiving single-agent docetaxel
      (T), followed by cyclophosphamide, epirubicin and 5-FU (CEF) to those
      receiving docetaxel with capecitabine (XT), followed by
      cyclophosphamide, epirubicin and capecitabine (CEX) in the adjuvant
      treatment of early breast cancer.
    - Secondary objectives included the evaluation and comparison
       between the two treatment arms of:
         - Safety profile
         - Overall survival.


    Results to date show that:

    - 54 women in the capecitabine-containing arm had their cancer
      return, or died compared to 80 women in the non-capecitabine
      containing arm of the study.
    - There were fewer deaths among those taking the capecitabine-containing
      combination regimen (a 34% reduction in risk of death was observed in
      this group).
    - 43 wo
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SOURCE  The Finnish Breast Cancer Group
Copyright©2009 PR Newswire.
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