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Landmark COPD Trial UPLIFT(R) Shows SPIRIVA(R) HandiHaler(R) Sustained Lung Function Improvements Over Four Years
Date:10/5/2008

oup trial. The study included 5993 male and female COPD patients. Patients were randomized 1:1 to receive either 18 micrograms tiotropium or placebo once daily. In both arms, patients were allowed to take all other respiratory medications usually prescribed for the treatment of COPD, except for inhaled anticholinergics.

About SPIRIVA(R) HandiHaler(R)

SPIRIVA HandiHaler is a once-daily inhaled maintenance prescription treatment for breathing problems (airway narrowing) associated with chronic obstructive pulmonary disease (COPD). COPD includes both chronic bronchitis and emphysema.

SPIRIVA does not replace fast-acting inhalers for sudden symptoms.

Do not swallow the SPIRIVA capsule. Only use the HandiHaler device to take the SPIRIVA capsule. Do not use the HandiHaler to take any other medications.

Do not get SPIRIVA powder in your eyes.

The most common side effect with SPIRIVA is dry mouth. Others include constipation and problems passing urine. For a complete list of reported side effects, ask your doctor or pharmacist.

Tell your doctor about your medicines, including eye drops, and illnesses like glaucoma and urinary or prostate problems. These may worsen with SPIRIVA.

If you have vision changes, eye pain, your breathing suddenly worsens, you get hives, or your throat or tongue swells, stop taking SPIRIVA and contact your doctor.

Do not use SPIRIVA if you are allergic to atropine, ipratropium, tiotropium bromide, or lactose. A lactose allergy is not the same as lactose intolerance.

Read the step-by-step Patient's Instructions for Use for SPIRIVA before you take your medicine.

For full prescribing information, please visit http://www.spiriva.com.

About Boehringer Ingelheim Pharmaceuticals, Inc.

Boehringer Ingelheim Pharmaceuticals, Inc., based in Ridgefield, CT, is the largest U.S. subsidiary of Boehringer Ingelheim Corporatio
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SOURCE Boehringer Ingelheim Pharmaceuticals, Inc.; Pfizer
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