Navigation Links
Lakewood-Amedex Inc. to Develop Broad Spectrum Influenza Drug to Include H1N1 and H5N1 Type A Strains

SARASOTA, Fla., Aug. 27 /PRNewswire/ -- Lakewood-Amedex Inc., (L-A), the anti-infectives biopharmaceutical company developing a unique portfolio of anti-bacterial and anti-viral products including NuBiotics, a novel family of synthetic anti-bacterial compounds, and anti-viral products against hepatitis, HIV and influenza, announced today that it is accelerating development of its broad spectrum anti-influenza product into clinical studies.

Lakewood-Amedex's nRNA product works by selectively silencing targeted genes in the viral genome. The company is building on the previously successful animal model study where mice infected with H1N1 type A influenza virus were given two doses of the L-A nRNA product and all survived while control and placebo dosed mice all died within six days. In addition L-A previously published a study demonstrating the effectiveness of its technology against the lethal H5N1 "bird flu" influenza virus in which a single intra-nasal dose of the company's nRNA product protected 100% of the infected chickens while placebo treated chickens all died within seven days.

Steve Parkinson, L-A's President and Chief Executive Officer, commented, "We had intended to develop our broadly applicable influ-RNA product to treat seasonal flu and as an emergency stockpile product in the event of a further outbreak of avian influenza, but due to the escalating global H1N1 pandemic and now the report of this virus having been isolated from turkeys in Chile, we feel it is critical to have a product that can target multiple strains of influenza and is useable year after year."

Mr. Parkinson explained that the L-A product does not work like a vaccine that stimulates the human host immune system to produce antibodies targeted at the specific viral strain composing the vaccine. Instead the nRNA product contains several short oligonucleotide sequences that are mirror images to unique sites on the viral mRNA from the viral replicative genes. When the nRNA comes into contact with its specific target, it hybridizes with the viral mRNA locking this mRNA up and preventing production of vital viral replicative proteins. Deprived of these, the virus is unable to multiply itself and rendered unable to spread and infect other cells.

Paul DiTullio, chief scientist for Lakewood-Amedex said, "We are essentially shutting the virus down in the infected person. By targeting the highly conserved replicative genes we have a product that should be useable for years even if the virus mutates. We are also hitting several genetic sites and the chances of them all mutating in the same season is minimal. Even if the H1N1 strain does undergo recombination with the deadly H5N1 strain our product will still shut it down." DiTullio added, "That is the limitation with vaccines. They stimulate antibody production in the host against the surface antigens of the virus but unfortunately it is the surface antigens that mutate most of the time requiring a new vaccine to be developed. Our product works independently of surface antigen mutation."

Mr. Parkinson commented, "The Company intends to complete its pre-clinical data package and enter human clinical trials as quickly as possible. We are talking to government agencies and potential partners and hope soon to have a universal anti-influenza product as an alternative to seasonal vaccines."

About Lakewood-Amedex Inc.

Lakewood-Amedex is a privately held development-stage biopharmaceutical company with a broad patent portfolio of inventions, including, 24 granted and/or issued patents and 45 patent applications covering its proprietary NuBiotics family of anti-microbial products, proven to be effective against a wide range of bacteria, encompassing antibiotic resistant strains including methicillin-resistant Staphylococcus aureus (MRSA), Pseudomonas and others, and patents covering certain proprietary products targeting pandemic viral infections including Epstein Barr Virus (EBV), human and avian influenza, Hepatitis B and C and other clinical indications. The Company anticipates initiating human clinical trials for topical use of its Nu-3 NuBiotics compound in the near future for indications including diabetic ulcers and other topical infections. Future studies will involve the use of Nu-2 to treat broad spectrum antibiotic-resistant bacterial pulmonary and systemic infections. The company is currently conducting a human IRB clinical study to improve treatment of nasopharyngeal carcinoma in Changsha, China. Lakewood-Amedex is headquartered in Sarasota, FL.

SOURCE Lakewood-Amedex Inc.
Copyright©2009 PR Newswire.
All rights reserved

Related medicine technology :

1. Karolinska Development Portfolio Company Launches GMP Facility for Particulate Manufacturing
2. New Consortium to Develop Drugs for Neglected Tropical Diseases
3. OncoGenex Expands Clinical Development of OGX-427 with a Phase 1 Clinical Trial in Bladder Cancer
4. Juvenile Diabetes Research Foundation, The Genomics Institute of the Novartis Research Foundation Announce Innovative Diabetes Drug Discovery and Development Partnership
5. Debiopharm Group and Mercury Therapeutics, Inc. Sign an Exclusive License Agreement for the Development and Commercialisation of Debio 0930
6. Access Pharmaceuticals Provides Update on ProLindac Clinical Development Program
7. Cryo-Cell Announces Celle(SM) Research and Development Collaboration with Cryopraxis Cryobiology Ltd.
8. Tibotec Pharmaceuticals Announces Agreement to Develop and Commercialize a New Fixed-Dose Combination of TMC278 and Truvada(R) With Gilead Sciences
9. Current Status of the Development Programs of New Indications and Formulations for Aricept(R) for Enhancing Patient Value
10. Transave Receives $2.2 Million Cystic Fibrosis Foundation Award for Development of ARIKACE(TM)
11. ADHD Genes Found; Known to Play Roles in Neurodevelopment
Post Your Comments:
(Date:11/27/2015)... November 27, 2015 Une ... photodynamique au Bremachlorin contre le cancer avancé. ... à combiner l,immunothérapie au traitement photodynamique au Bremachlorin ... Une nouvelle approche consistant à combiner ... cancer avancé.    Clinical Cancer ...
(Date:11/27/2015)... , Nov. 27, 2015  Lannett Company, Inc. ... has completed the acquisition of Kremers Urban Pharmaceuticals ... of global biopharmaceuticals company UCB S.A. (Euronext: UCB). ... Lannett has acquired KU from UCB for total ... adjustments, including a customary working capital adjustment, a ...
(Date:11/26/2015)... , November 27, 2015 ... --> --> ... emergency response system (PERS) market ... for 5 years with APAC ... expected to see a high ...
Breaking Medicine Technology:
(Date:11/29/2015)... ... 2015 , ... Doctors who missed a case of mesothelioma in a 70-year-old ... and push for a diagnosis, especially in people exposed to asbestos. Surviving Mesothelioma has ... it now. , Researchers at Gifu Prefectural Tajimi Hospital in Japan say ...
(Date:11/28/2015)... ... November 28, 2015 , ... Safe storage for contraceptive devices may not always ... Lakewood, New Jersey and the other from Bradley Beach, New Jersey, there is an ... expense of having to replace NuvaRings more often than necessary. As such, it affords ...
(Date:11/27/2015)... (PRWEB) , ... November 27, 2015 , ... According to ... the recent 2015 American Dental Association meeting in Washington D.C. revolved around the fact ... a patient’s overall health. The talk stressed the link between periodontal disease (more commonly ...
(Date:11/27/2015)... ... November 27, 2015 , ... An inventor, ... to dispense prescription medications at home, so he invented the patent-pending ELECTRONIC M.D. ... dispense prescription medications. In doing so, it could help to prevent potential overdose ...
(Date:11/27/2015)... ANGELES, CA (PRWEB) , ... November 27, 2015 , ... MPWH, the No.1 Herpes-only dating ... of 30 (see Table 1-1 ). More than 3.7 billion people under the ... virus type 1 (HSV-1), according to WHO's first global estimates of HSV-1 infection . ...
Breaking Medicine News(10 mins):