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Lakewood-Amedex Announces Results Demonstrating The More Rapid Direct Bactericidal Activity Of Novel Bisphosphocin Class Of Antimicrobials
Date:5/16/2013

SARASOTA, Fla., May 16, 2013 /PRNewswire/ -- Lakewood-Amedex Inc., a leading developer of novel anti-infective pharmaceuticals, announced today that a recent series of in vitro studies have provided new evidence that its novel class of antimicrobials, named bisphosphocins, function through a completely unique mechanism of action involving bacterial membrane depolarization, resulting in rapid direct bacterial killing.  These studies expand on previously published experiments demonstrating Nu-3 to be superior to ciprofloxacin.  The studies revealed the ability of Nu-3 to generate a >5 log reduction in bacterial counts of stains such as Klebsiella pneumonia and Acinetobacter baumanii in as little as five minutes, or less time than these bacteria take to replicate.  Using the standard "post-antibiotic affect" protocol, designed to assess the delay in growth caused by traditional antibiotics, the >5 log reduction in bacterial cell counts represents the maximum value achievable in these assays due to the rapid direct killing mechanism of bisphosphocins and resulting in no bacterial growth. 

This result is significant because the unique bisphosphocin mechanism of action eliminates many of the current problems in the treatment of bacterial or fungal diseases, namely the development of microbial resistance, and can eradicate slow growing or stationary bacteria and bacterial biofilms, constantly a major problem for the medical community.  Traditional antibiotics only inhibit bacterial growth, typically through a single target molecule, thus requiring a prolonged exposure that provides an opportunity for the bacteria to mutate and become resistant or dormant to avoid the antibiotic affecting them.  In the case of bisphosphocins, the effect is directly bactericidal and does not depend on the bacteria being in a growth cycle, eliminating any opportunity for the development of resis
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SOURCE Lakewood-Amedex Inc.
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