Navigation Links
LX4211 Phase 2b Results Presented At American Heart Association Annual Conference
Date:11/6/2012

THE WOODLANDS, Texas, Nov. 6, 2012 /PRNewswire/ -- Lexicon Pharmaceuticals, Inc. (Nasdaq: LXRX) announced that data from the Phase 2b clinical trial of LX4211 are being presented today as a Clinical Sciences Special Report in the Emerging Therapeutics for Diabetes and Dyslipidemia section of the American Heart Association (AHA) Scientific Sessions Conference held in Los Angeles, California.  The oral presentation is being delivered by Dr. Julio Rosenstock, Director of the Dallas Diabetes and Endocrine Center at Medical City, lead investigator in the recently completed study.

"The results from this trial demonstrate potential benefits of inhibiting SGLT1 in addition to the known effects of SGLT2 inhibition, not only in improving glycemic control, but also in achieving reductions in important cardiovascular risk factors such as blood pressure and body weight with an apparent favorable safety profile that will need confirmation by long-term controlled trials," said Dr. Rosenstock.  

LX4211, an investigational, oral, dual inhibitor of sodium glucose co-transporters 1 and 2 (SGLT1 and SGLT2), reduces the amount of glucose that enters the bloodstream from the gastrointestinal (GI) tract by inhibiting SGLT1, the major transporter responsible for glucose absorption, and enhances glucose excretion in the urine by inhibiting SGLT2, the major transporter responsible for glucose reabsorption by the kidney. In the trial, LX4211 was tested in 299 patients with poorly controlled type 2 diabetes on metformin therapy. Patients were randomized to receive LX4211 at doses of 75 mg QD, 200 mg QD, 200 mg BID, 400 mg QD, or placebo for 12 weeks. New data presented today showed that maximal 24-hour urinary glucose excretion occurred at 200 mg QD dose, whereas maximal HbA1c reduction was obtained at the 400 mg QD dose. This suggests that dual
'/>"/>

SOURCE Lexicon Pharmaceuticals, Inc.
Copyright©2012 PR Newswire.
All rights reserved

Page: 1 2 3 4

Related medicine technology :

1. Lexicon Announces Publication of Results of Two Studies of LX4211 in Patients with Type 2 Diabetes in the Journal Clinical Pharmacology & Therapeutics
2. Lexicon Announces Positive Results of LX4211 Phase 2b Trial For Type 2 Diabetes
3. Lexicon Presents Data Regarding the Mechanism of Action and Safety of LX4211 at American Diabetes Association Meeting
4. Lexicon Receives Funding for Phase 2 Clinical Trial of LX4211 in Type 1 Diabetes
5. Zafgen Announces Initiation of Phase 2a Clinical Development with Beloranib in Obesity
6. Isis Announces Expedited Development Of ISIS-TTR Rx And Amendment To The Collaboration With GSK To Support Phase 2/3 Study
7. AcelRx Pharmaceuticals Doses the First Patients in ARX-04 Phase 2 Clinical Study
8. Omeros Ophthalmology Product OMS302 Successful in Second Phase 3 Clinical Trial
9. Amgen To Present Data From Four Phase 2 Studies At Upcoming American Heart Association Scientific Sessions 2012
10. Omthera Pharmaceuticals Announces Invitation to Attend Presentation of the Complete Data Sets from its Phase 3 EVOLVE and ESPRIT Clinical Studies
11. Janssen and Johnson & Johnson to Provide Webcast Presentation of Immunology Pivotal Phase 3 Data Being Presented at the American College of Rheumatology Annual Meeting
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/23/2015)... Jan. 23, 2015 /PRNewswire/-- Harwood Feffer LLP ( www.hfesq.com ) ... of Advaxis, Inc. ("Advaxis" or the "Company") (NASDAQ: ... its fiduciary duties to shareholders. On January ... website reporting that Advaxis had misrepresented the clinical data ...
(Date:1/23/2015)... Jan. 23, 2015  HyGreen, Inc., a leader in hand ... with RCA Medical, a subsidiary of Ascendis Health Limited, ... Each year, hundreds of millions of patients around ... organisms are transmitted from patient to patient via the ...
(Date:1/23/2015)... , Jan. 23, 2015  iMD Companies, Inc. (ICBU) has repositioned ... market share and grab a foothold in the hydroponic, hemp ... capabilities and a presence in the sector, and recently partnering ... growth of hemp and medical marijuana, iMD is committing to ...
Breaking Medicine Technology:Harwood Feffer LLP Announces Investigation of Advaxis, Inc. 2HyGreen Partners with RCA Medical in Johannesburg, South Africa 2iMD Companies Poised to Make Impact in Multi-Billion Dollar Medical Marijuana Sector With Recent Investments and Strategic Partnerships 2
... N.J. and LACHEN, Switzerland, Sept. 26, 2011 ... largest human protein products manufacturers in the world, has ... efficacy and safety of wilate® (von Willebrand ... post-operative bleeding in pediatric and adult patients with Type ...
... Accuray Incorporated (Nasdaq: ARAY ), the premier ... to present at the JMP Securities Healthcare Conference in New ... a.m. PDT. A live webcast of the presentation ... the Company,s website at http://www.accuray.com . The webcast replay ...
Cached Medicine Technology:Octapharma Launches Clinical Trial to Evaluate Efficacy & Safety of wilate® In Preventing Surgical Bleeding in Type 3 von Willebrand Disease Patients 2Octapharma Launches Clinical Trial to Evaluate Efficacy & Safety of wilate® In Preventing Surgical Bleeding in Type 3 von Willebrand Disease Patients 3
(Date:1/22/2015)... The Incredible Bulk is a revolutionary method ... lean muscle by up to 30lbs in less than 12 ... HealthyandFitZone.com’s Stan Stevenson, prompting an investigative review. , “Our ... scientific diet formula that allows the body to pack on ...
(Date:1/22/2015)... Orlando, Florida (PRWEB) January 22, 2015 ... up today at the 2015 PGA Merchandise Show to ... lady and incredible female amateur golfer, Arlene McKitrick. The ... career female amateur golf tournament win. She won her ...
(Date:1/22/2015)... released a new blog post presenting the basic features of ... an accidental death and dismemberment rider for a car insurance ... benefits if the insured dies in an accident. Accidental death ... insurance. , AD&D is not expensive and can be ...
(Date:1/22/2015)... 2015 IsoComforter, Inc. has introduced the most ... IsoTube design to treat specific body parts and muscle groups. ... and easy to use patented cold therapy machine with the ... orthopedic and muscle injuries. IsoComforter has become the industry ...
(Date:1/22/2015)... a famous dress online store for wedding dresses and other ... of wedding dresses , and launches a site-wide women’s dress ... on your big day; the wedding gown is the most ... find the most suitable wedding dress. Now, we are proud ...
Breaking Medicine News(10 mins):Health News:The Incredible Bulk: Review Examining Ben Pakulski’s Brand New Bulking Muscle Building Diet Program Released 2Health News:All-Time Leading Female Amateur Golfer Arlene McKitrick Receives Juvent Sports Achievement Award at 2015 PGA Show 2Health News:All-Time Leading Female Amateur Golfer Arlene McKitrick Receives Juvent Sports Achievement Award at 2015 PGA Show 3Health News:Accidental Death and Dismemberment Insurance Can Be Purchased at Low Prices Online 2Health News:IsoComforter Introduces Best of Class Cold Therapy Product to the Worldwide Market 2Health News:Find The Most Suitable Wedding Dress At JJsHouse.com 2
... ... offering to the Life Sciences, University, and Clinical research labs with the BacBASIC Environmental ... , ... 29, 2010 -- Anaerobic Glove Boxes have made a name for themselves over the ...
... ... world on the benefits of natural health. His popular health podcast aired its 100th ... ... J. Richards, celebrated the 100th episode of his popular health podcast June 17, 2010. ...
... , ... inhalers have been taken off the U.S. market, forcing countless patients to find an equivalent ... and frustrations, and have found that they are not alone with their struggle. Learn more ... ...
... BROOK, Ill. Advanced imaging technologies have helped shift ... percutaneousor through the skintechniques, according to a new study ... the journal Radiology . Biopsythe removal ... history in medicine. The first percutaneous needle biopsy of ...
... rates for exercise will need to do some new math as ... formula based on a large study from Northwestern Medicine provides a ... should attain during exercise. It also will more accurately predict the ... "Now we know for the first time what is normal for ...
... ... obesity crisis in our nation. HOPSports and Hyper Wear are teaming up to reach ... System® in cooperation with Hyper Wear,s safe and effective SandBell® weights. , ... Valencia, CA and Austin, TX (PRWEB) June ...
Cached Medicine News:Health News:Sheldon Manufacturing, Inc. Announces New Ergonomic Bactron Anaerobic Chamber For Microbiology Research 2Health News:Health Podcast by World-Renowned Health Educator Celebrates 100th Episode and Continues to Offer Life-Changing Advice 2Health News:Impact of Azmacort Withdrawal Brought to Light in Medicine Community 2Health News:Impact of Azmacort Withdrawal Brought to Light in Medicine Community 3Health News:Impact of Azmacort Withdrawal Brought to Light in Medicine Community 4Health News:Impact of Azmacort Withdrawal Brought to Light in Medicine Community 5Health News:Use of less invasive, imaging-guided biopsies on the rise 2Health News:New formula gives first accurate peak heart rate for women 2Health News:HOPSports, Inc. Adds SandBell to Award-Winning Training System 2Health News:HOPSports, Inc. Adds SandBell to Award-Winning Training System 3
... The Hoffmann® II Hybrid External ... the next generation in hybrid fixation. ... trauma surgeons and is designed to ... our exclusive patented Hoffmann® snap-fit technology. ...
... individual components for individual indications. XCaliber covers ... of an innovative composite plastic material, XCaliber ... lighter. This means it's easier to handle, ... the patient. ,Come pre-assembled, packaged sterile, and ...
The Hybrid Fixator consists of Three basic components: rings, wires, clamps. Final fracture reduction can be easily performed after frame assembly....
... associated with displaced pelvic fractures is one ... orthopaedic and trauma surgeons. , ,Recognizing the ... external fixation, and internal fixation in these ... been developed as a method to provide ...
Medicine Products: