Navigation Links
Kosan's Second-Generation Hsp90 Inhibitor, Alvespimycin, Shows 42% Clinical Benefit in Phase 1 HER2-Positive Metastatic Breast Cancer Trial
Date:9/10/2007

ety profile of this triplet regimen and to lay the groundwork for a potential larger Phase 2/3 trial. We expect to start our Phase 2 monotherapy trial in newly-diagnosed HER2-positive patients later this year. We believe that the clinical activity of alvespimycin seen in our breast cancer Phase 1 trials to date validates the compound's therapeutic potential as a novel anticancer agent and strengthens Kosan's leadership in the Hsp90 inhibitor area."

Phase 1 Updated Results

Alvespimycin is a second-generation Hsp90 inhibitor that has demonstrated the potential to disrupt the activity of multiple oncogenes and cell signaling pathways implicated in tumor growth, including HER2, a key signaling pathway in breast cancer.

Preliminary results from the Phase 1 trial of alvespimycin in combination with trastuzumab were presented at the 2007 ASCO annual meeting in June, and were updated in this presentation. The Phase 1 trial was designed to identify the recommended Phase 2 dose through the evaluation of toxicity and activity in patients with solid tumors. Patients were enrolled in three dose cohorts. The dosing schedule for alvespimycin was a one-hour weekly intravenous infusion of 60, 80 or 100 mg/m2 administered along with the standard dose of trastuzumab. Patients were assessed every 4 weeks for toxicity and every 8 weeks for response. Disease response was assessed by RECIST and by tumor markers, if available.

Of the 27 heavily-pretreated patients enrolled in the trial, 24 patients had HER2-positive breast cancer (with the majority of patients having had multiple trastuzumab-containing regimens prior to this study) and 3 patients had ovarian cancer (HER2 status unknown).

Clinical benefit was observed in 42% of evaluable patients (8 of 19 evaluable) with HER2-positive metastatic breast cancer:

-- 1 patient (13 prior regimens, including progression on single-agent

lapatinib and 3 prior trastuzumab-containing regimens) showed compl
'/>"/>

SOURCE Kosan Biosciences Incorporated
Copyright©2007 PR Newswire.
All rights reserved

Page: 1 2 3 4 5

Related medicine technology :

1. Positive Results for Second-Generation Taxus Liberte Coronary Stent System Highlighted in Journal of American College of Cardiology
2. Kosan Presents Promising Phase 1 Data on Second-Generation Hsp90 Inhibitor, Alvespimycin, Showing Antitumor Activity in Refractory Breast and Ovarian Cancers at ASCO
3. Kosan Presents Data on Lead Hsp90 Inhibitor, Tanespimycin, Showing Promising Antitumor Activity in Multiple Myeloma at ASCO
4. Kosan Presents Preliminary Phase 2 Data Showing Antitumor Activity of Hsp90 Inhibitor Tanespimycin in Metastatic Melanoma at ASCO
5. Kosan Presents Data on Cardiac Safety Profile of Hsp90 Inhibitor Tanespimycin (KOS-953) at AACR
6. Arisaph Pharmaceuticals Announces Results of its Potent Smart DPP-4 Inhibitor, ARI-2243, at the ADA
7. Clinical Data on ARIADs Novel mTOR Inhibitor, AP23573, To Be Presented at the ASCO Annual Meeting
8. ArQule Announces Acceptance of Clinical Data on ARQ 197, c-Met Inhibitor, for Oral Presentation at ASCO
9. Clinical Study Shows Regenecare Relieves Pain and Itching of Skin Rashes Caused by Widely Used Cancer Drugs
10. International ENDORSE Study Shows That the Majority of Hospitalized Patients Surveyed are at Risk for VTE and Many do not Receive Recommended VTE prophylaxis
11. New Study Shows That Extending Prophylaxis With Clexane / Lovenox (enoxaparin Sodium Injection) to 5 Weeks is More Effective Than 10 Days for Reducing the Risk of Venous Thromboembolism (VTE) in Acutely ill Medical Patients With Reduced Mobility
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/5/2015)... CITY, Calif. , May 5, 2015  Abaxis, Inc. ... blood analysis systems, announced today that Clint Severson , ... of America Merrill Lynch 2015 Health Care Conference on Tuesday, ... be held at the Encore at the Wynn in ... Inc. is a worldwide developer, manufacturer and marketer of portable ...
(Date:5/5/2015)... , May 5, 2015  InfuSystem Holdings, Inc. ... pumps and related services for the U.S. healthcare industry, ... results on Tuesday, May 12, 2015 after the market ... conference call for investors on Tuesday, May 12, 2015 ... performance and results.  To participate in this call, please ...
(Date:5/5/2015)... , May 5, 2015 ... or "the Group"), the regenerative medical devices company, ... a new regional distribution contract for DermaPure® which ... acute wounds.      (Logo: http://photos.prnewswire.com/prnh/20150505/743321) , ... in Dermapure® since Tissue Regenix received notice of ...
Breaking Medicine Technology:Tissue Regenix Group plc: US Regional Distribution Agreement Signed 2
...  A number of large pharmaceutical and biotech companies are ... genomic technologies and molecular biology segments will boost the ... MicroRNA is set to unveil a new era in ... New analysis from Frost & Sullivan ( ...
... 23, 2012 Reportlinker.com announces that a ... its catalogue: Pharmaceuticals ... Guide http://www.reportlinker.com/p0191857/Pharmaceuticals---Global-Group-of-Eight-G8-Industry-Guide.html#utm_source=prnewswire&utm_medium=pr&utm_campaign=Pharmaceu ... (G8) Industry Guide is an essential resource ...
Cached Medicine Technology:MicroRNA Research to Trigger Tremendous Growth in Related Tools Market, Says Frost & Sullivan 2MicroRNA Research to Trigger Tremendous Growth in Related Tools Market, Says Frost & Sullivan 3MicroRNA Research to Trigger Tremendous Growth in Related Tools Market, Says Frost & Sullivan 4Pharmaceuticals - Global Group of Eight (G8) Industry Guide 2Pharmaceuticals - Global Group of Eight (G8) Industry Guide 3Pharmaceuticals - Global Group of Eight (G8) Industry Guide 4Pharmaceuticals - Global Group of Eight (G8) Industry Guide 5Pharmaceuticals - Global Group of Eight (G8) Industry Guide 6Pharmaceuticals - Global Group of Eight (G8) Industry Guide 7Pharmaceuticals - Global Group of Eight (G8) Industry Guide 8Pharmaceuticals - Global Group of Eight (G8) Industry Guide 9Pharmaceuticals - Global Group of Eight (G8) Industry Guide 10Pharmaceuticals - Global Group of Eight (G8) Industry Guide 11Pharmaceuticals - Global Group of Eight (G8) Industry Guide 12Pharmaceuticals - Global Group of Eight (G8) Industry Guide 13Pharmaceuticals - Global Group of Eight (G8) Industry Guide 14
(Date:5/5/2015)... May 05, 2015 RF Technologies®, a ... the Sensatec® ST750 Fall Management Solution with Voice Alarms. ... monitored patient or resident to wait for assistance when ... have the choice of 16 different melodies or tones ... call system such as Code Alert®. , For ...
(Date:5/5/2015)... May 05, 2015 Don’t have time ... for a fitness membership? Don’t know which workout equipment ... obstacles in order to help members achieve their heath ... Streaming Fitness, an educational, caused-based wellness company, today announces ... streaming fitness classes led by certified trainers, nutritional information ...
(Date:5/5/2015)... 2015 What do you get when you ... world’s greatest mountaineers and one of the world’s greatest causes? ... 54-minute documentary by Marc Middleton, which follows world-renowned mountaineer Chris ... the 19,341-foot frozen summit of Mount Kilimanjaro. , “This ... call to action. Viewers are moved to ask, ‘What can ...
(Date:5/5/2015)... (PRWEB) May 05, 2015 In the upbeat ... it is for moms to support each other. Parenting ... each other’s side makes it so much easier. Mothers ... feel better, feel less alone and help them realize there’s ... can. Moms who are clearly dear friends share that ...
(Date:5/5/2015)... May 05, 2015 Sheltering Arms held ... Walt “Clyde” Frazier and Cravath, Swaine & Moore LLP ... highest-need communities. The event was co-chaired by Vanguard sponsors ... “The Next Chapter” highlighted Sheltering Arms’ significant growth in ... unveiled in February 2015. Formerly Episcopal Social Services, Sheltering ...
Breaking Medicine News(10 mins):Health News:RF Technologies® Releases Sensatec® ST750 Voice Alarm for Fall Management 2Health News:RF Technologies® Releases Sensatec® ST750 Voice Alarm for Fall Management 3Health News:Live Streaming Fitness Creates Industry Shift by Bringing Fitness, Nutrition and Cooking Classes to Smart Devices 2Health News:Live Streaming Fitness Creates Industry Shift by Bringing Fitness, Nutrition and Cooking Classes to Smart Devices 3Health News:LIVESTRONG & Bolder Broadcasting Present Special Edition of Conquering Kilimanjaro 2Health News:LIVESTRONG & Bolder Broadcasting Present Special Edition of Conquering Kilimanjaro 3Health News:Just In Time For Mother’s Day, Healthy Birth Day Releases Video Titled “Moms Helping Moms” Encouraging Mothers To Band Together 2Health News:Sheltering Arms Honors Walt "Clyde" Frazier and Cravath, Swaine & Moore LLP at Annual Gala 2
... Corporation,(Pink Sheets: GCHC.PK) announced the formation of TongRenTang ... new company, which is,owned equally by the two ... treatments and products based upon China,s famous,TongRenTang herbal ... Qigong, reflexology and many other oriental,treatments as well ...
... Advisors Transitioning to Independence, SAN FRANCISCO, ... new relationship with national human resources,outsourcing company ... for,independent investment advisors and their employees. As ... advisors who custody,assets with Schwab will now ...
... Va., Oct. 15 Sallie Mae employees,were recognized ... Team,Messenger Award for fielding the largest team at ... of events held around the,country. (Logo: ... of 276 Sallie Mae employees, family members, and,friends ...
... Company Revenues Up 9.9% For Fiscal Year Ended 2007, ... NYER ) today reported the audited financial results for its,fiscal ... for,fiscal year ended June 30, 2007 as compared to $63,596,975 ... Company reported a net income of,$86,446 or $.02 basic net ...
... insight into the mechanisms involved in resistance to treatment ... published by Cell Press in the October issue of ... may help to identify patients who are unlikely to ... for treating these patients. , Trastuzumab is an antibody ...
... of Texas, 181,legislators are being honored with the ... accomplishments on behalf of health care,during the 80th ... created the award in 1997 to honor state ... on issues important,to hospitals and health systems. ...
Cached Medicine News:Health News:Greater China Corporation Forms TongRenTang Wellness Corporation 2Health News:Schwab Institutional Introduces Healthcare and Benefits Assistance for Independent Advisor Firms 2Health News:Schwab Institutional Introduces Healthcare and Benefits Assistance for Independent Advisor Firms 3Health News:Schwab Institutional Introduces Healthcare and Benefits Assistance for Independent Advisor Firms 4Health News:Sallie Mae Employees Receive Award for Largest National Team at Lance Armstrong Foundation Fundraising Events 2Health News:Nyer Medical Group, Inc. Reports EPS of $.02 on Record Revenues of $69.9 Million for Fiscal Year Ended 2007 2Health News:Nyer Medical Group, Inc. Reports EPS of $.02 on Record Revenues of $69.9 Million for Fiscal Year Ended 2007 3Health News:Nyer Medical Group, Inc. Reports EPS of $.02 on Record Revenues of $69.9 Million for Fiscal Year Ended 2007 4Health News:Genetic approach provides new insight into trastuzumab resistance in breast cancer 2Health News:THA Honors Nine Legislators for Contributions to Health Care 2
... Reference Series 2000 Pipette is a synonym ... compact and robust design, and superior operating ... to operate the measuring stroke and blow-out ... features:Eppendorf "pipette/tip" system ensures utmost accuracy and ...
... Reference Series 2000 Pipette is a synonym ... compact and robust design, and superior operating ... to operate the measuring stroke and blow-out ... features:Eppendorf "pipette/tip" system ensures utmost accuracy and ...
... The Eppendorf Reference Series 2000 Pipette ... smooth stroke, a compact and robust design, ... button is used to operate the measuring ... the tip. Product features:Eppendorf "pipette/tip" system ensures ...
Pipetman F is a fixed-volume, air-displacement pipette. Thirteen robust models cover a large volume range from 2 L to 1000 L, with Gilsons legendary accuracy and precision....
Medicine Products: