Navigation Links
Kosan's Lead Hsp90 Inhibitor, Tanespimycin, Shows High Level of Activity in Trastuzumab Resistant/Refractory HER2-Positive Breast Cancer in a Phase 2 Trial
Date:6/3/2008

ng additional studies with tanespimycin with the goal of further characterizing the drug candidate's safety and efficacy profile and potentially paving the way to a registration program. Patients currently enrolled in the ongoing Phase 2 trial of tanespimycin plus trastuzumab will continue on study per protocol. Kosan does not plan to enroll additional patients in this trial.

About Kosan

Kosan Biosciences is a biotechnology company advancing two new classes of anticancer agents through clinical development -- a Hsp90 (heat shock protein 90) inhibitor and an epothilone. Hsp90 inhibitors have a novel mechanism of action targeting multiple pathways involved in cancer cell growth and survival. Tanespimycin (KOS-953) is being tested in combination with Velcade(R) (bortezomib) in patients with multiple myeloma in a clinical program called TIME. Tanespimycin is also being studied in HER2-positive metastatic breast cancer in combination with Herceptin(R) (trastuzumab). KOS-1584 epothilone product candidate is in a Phase 2 clinical trial in patients with non-small cell lung cancer. Kosan's epothilone program is licensed to Bristol-Myers Squibb. Kosan's motilin agonist compound, KOS-2187, licensed to Pfizer for development in gastroesophagel reflux disease, is in a Phase 1 trial. Kosan recently agreed to be acquired by Bristol-Meyers Squibb. For additional information on Kosan Biosciences, please visit the company's website at http://www.kosan.com.

This press release contains forward-looking statements within the meaning of the "safe harbor" provisions of the Private Securities Litigation Reform Act of 1995 (the "Act"). Such forward-looking statements include but are not limited to statements regarding the further development and potential safety, efficacy, regulatory status, commercial potential and other characteristics of Kosan's product candidates; the continuation of current clinical trials; the initia
'/>"/>

SOURCE Kosan Biosciences Incorporated
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6

Related medicine technology :

1. NexGenix Pharmaceuticals Presents Data on a Novel Small Molecule Inhibitor of Heat Shock Protein 90 (Hsp90) at the GTCbio Cancer Drugs Research & Development Conference
2. Kosan Initiates Phase 2 Trial of Alvespimycin, Second-Generation Hsp90 Inhibitor, in HER2-Positive Metastatic Breast Cancer
3. Kosan Presents Updated Data on Hsp90 Inhibitor, Tanespimycin, in Multiple Myeloma at Ash
4. First High-Res 3-D Structures of Mammalian HSP90 Protein Solved, Key to Better Targets for AIDS, Sepsis, Cancer Drugs
5. Kosans Second-Generation Hsp90 Inhibitor, Alvespimycin, Shows 42% Clinical Benefit in Phase 1 HER2-Positive Metastatic Breast Cancer Trial
6. Kosan Opens Registration Program for Lead Hsp90 Inhibitor, Tanespimycin, in Multiple Myeloma
7. BiPar Sciences Expands Clinical Development of BSI-201, A Novel PARP Inhibitor, With Phase 2 Trial in Uterine Cancer
8. BiPar Sciences Announces Clinical Data Presentations on Lead PARP Inhibitor, BSI-201, at 40th American Society of Clinical Oncology Annual Meeting
9. BiPar Sciences Expands Phase 2 Clinical Trials of BSI-201, a Novel DNA Repair Inhibitor, in Ovarian Cancer
10. SuperGen Identifies Lead PIM Kinase Inhibitor, SGI-1776, That Causes Tumor Regression in AML Xenograft Models
11. SuperGens DNA Methyltransferase Inhibitor, S-110, Improves In Vivo Efficacy Profile of Decitabine
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/21/2015)... 2015 Global cap & closure ... for caps and closures will exceed $55 billion in 2019. ... trillion annually. Beverages will continue to account for well over ... number of smaller markets are expected to register faster growth. ... the most developed markets -- the US, Western ...
(Date:4/21/2015)... Fla. , April 21, 2015  A new, ... the First Coast that promises to revolutionize the way ... fellowship-trained at the world-renowned Montsouris Institute in ... guided prostate biopsy in the North Florida ... this innovative technology in prostate cancer diagnosis and management ...
(Date:4/21/2015)... SARASOTA, Fla. , April 21, 2015   ... a drug development company focused on the treatment of ... a key independent appointment to the Company,s Board of ... Chundru Samuel as a new director. ... CEO of Rock Creek Pharmaceuticals, said, "Dr. Samuel,s experience ...
Breaking Medicine Technology:World Caps & Closures Market 2World Caps & Closures Market 3Kasraeian Urology Unveils Jacksonville's First UroNav Advanced Prostate Cancer Detection Technology 2Kasraeian Urology Unveils Jacksonville's First UroNav Advanced Prostate Cancer Detection Technology 3Rock Creek Pharmaceuticals Appoints New Director and Provides Notice of Settlement of Derivative Litigation 2Rock Creek Pharmaceuticals Appoints New Director and Provides Notice of Settlement of Derivative Litigation 3Rock Creek Pharmaceuticals Appoints New Director and Provides Notice of Settlement of Derivative Litigation 4Rock Creek Pharmaceuticals Appoints New Director and Provides Notice of Settlement of Derivative Litigation 5Rock Creek Pharmaceuticals Appoints New Director and Provides Notice of Settlement of Derivative Litigation 6Rock Creek Pharmaceuticals Appoints New Director and Provides Notice of Settlement of Derivative Litigation 7
(Date:4/21/2015)... 2015 The report “Sinusitis ... analysis on the therapeutic development for Sinusitis. ... new targets and MOAs to produce first-in-class ... is available @ http://www.rnrmarketresearch.com/sinusitis-pipeline-review-h1-2015-market-report.html . ... involved in the therapeutic development for Sinusitis ...
(Date:4/21/2015)... April 21, 2015 Wireless Analytics, ... has been recognized by the Boston Business Journal as ... ranking was announced at a recent event celebrating the ... of the fastest-growing private companies in Massachusetts. , Wireless ... the state that recorded the fastest revenue growth from ...
(Date:4/21/2015)... April 21, 2015 QuickMedical, a ... and supplies, now represents Schiller America's ... ECGs, Stress Tests, and Vital Signs Monitors, among ... Switzerland, is a global leader in the development ... are developed in close cooperation with the world's ...
(Date:4/21/2015)... San Diego, CA (PRWEB) April 21, 2015 ... Deconstructed PACS® strategy , Visage Imaging ... Ltd. (ASX: PME), has signed a seven-year contract ... health system in Northern Florida. The deal furthers ... the university/academic hospital space, a key area of the ...
(Date:4/21/2015)... Baltimore, Maryland (PRWEB) April 21, 2015 ... air, according to the U.S. Environmental Protection Agency (EPA). ... UV rays and cigarette smoke increase the level of ... help the body eliminate these harmful toxins is to ... superfood, broccoli boasts the highest level of glucoraphanin – ...
Breaking Medicine News(10 mins):Health News:Sinusitis Therapeutic Development and Pipeline Market Review H1 2015 Available at RnRMarketResearch.com 2Health News:Sinusitis Therapeutic Development and Pipeline Market Review H1 2015 Available at RnRMarketResearch.com 3Health News:Wireless Analytics Ranked as 25th Fastest Growing Private Company in Massachusetts 2Health News:QuickMedical Launches New Product Line: Schiller America 2Health News:QuickMedical Launches New Product Line: Schiller America 3Health News:Visage Imaging Signs University of Florida Health 2Health News:Visage Imaging Signs University of Florida Health 3Health News:Visage Imaging Signs University of Florida Health 4Health News:New Survey Shows Americans Are Cooking the Health Out of Broccoli 2Health News:New Survey Shows Americans Are Cooking the Health Out of Broccoli 3
... governments, including California as well as others in Canada ... taxpayer dollars into major motion pictures that depict smoking ... year, a University of California, San Francisco (UCSF) researcher ... PLoS Medicine , those subsidies, along with government ...
... Aug. 23 (HealthDay News) -- Researchers say boys are ... that males have been reaching sexual maturity about 2.5 ... "The reason for earlier maturity for ... disease environments are getting more favorable for it," demographer ...
... By Amanda Gardner HealthDay Reporter , ... are hospitalized fail to receive their regular medications for ... restart them when they,re discharged, researchers say. Patients ... less likely to resume their regular medication schedule after ...
... Aug. 23 (HealthDay News) -- Certain types of mental illnesses ... indicates. Men are more likely to be diagnosed with ... to develop anxiety or depression, according to the researchers. ... efforts, said the study authors, who analyzed data collected in ...
... of Nottingham are to investigate whether the therapeutic effects ... their feelings of anger, anxiety and depression. Academics ... Contemporary art gallery and local artists for the innovative ... clay could offer to young people struggling with mental ...
... (HealthDay News) -- The amount of fighting and arguing in ... a new study suggests. Ohio State University researchers looked ... 1980 to 2000. Based on how often participants said they ... middle- and high-conflict marriages. There was little change in ...
Cached Medicine News:Health News:Taxpayer film subsidies promote youth smoking 2Health News:Boys Mature Sexually Earlier Than Ever Before: Study 2Health News:Mainstay Meds Often Cut Off Accidentally After Hospital Stay 2Health News:Mainstay Meds Often Cut Off Accidentally After Hospital Stay 3Health News:Mental Illness Affects Women, Men Differently, Study Finds 2Health News:Modelling emotions: A potential new therapy for disturbed teenagers 2Health News:Modelling emotions: A potential new therapy for disturbed teenagers 3Health News:Couples Who Don't Fight Much Aren't Likely to Start 2
... Combination gives you the freedom ... enhanced by distributing 70% of ... hips leaving only 30% of ... shoulders. Freedom of movement enhanced ...
A simple, one-piece design eliminates seams that irritate and also extend the life of the collar. Comes with extra long Velcro closure to fit all. Also available with trim. One size fits all. Availab...
The maternity apron is a very critical protection device for the patient and the fetus....
... Special Protective Apron is made to ... a sterile gown. Uniquely it can ... field. Reaching through the back of ... released, and the protective apron will ...
Medicine Products: