Navigation Links
Kosan's Lead Hsp90 Inhibitor, Tanespimycin, Shows High Level of Activity in Trastuzumab Resistant/Refractory HER2-Positive Breast Cancer in a Phase 2 Trial
Date:6/3/2008

er, and senior author on the poster. "We look forward to seeing tanespimycin advance into its next set of clinical trials with the goal of elucidating its potential role in the metastatic breast cancer treatment paradigm."

"Tanespimycin is the most advanced Hsp90 inhibitor in development for HER2-positive breast cancer and has generated what we believe is highly promising data in this indication," said Pamela Cohen, M.D., Kosan's Chief Medical Officer. "We believe that Hsp90 inhibition is among the most novel and broadly applicable anticancer targets being explored today, and that it may have broad applicability in breast cancer and other cancer indications."

Phase 2 Tanespimycin Data

Tanespimycin is an Hsp90 inhibitor that has demonstrated the potential to disrupt the activity of multiple oncogenes and cell signaling pathways implicated in tumor growth, including HER2, a key pathway in breast cancer.

The objective of the Phase 2 trial is to determine the objective response rate by RECIST in patients with HER2-positive metastatic breast cancer. To be eligible for the trial, patients must have had either progressive disease within 3 months following last dose of adjuvant treatment with trastuzumab or have progressive disease following initial therapy for metastatic disease with trastuzumab (trastuzumab may have been administered with cytotoxic chemotherapy or as a single agent). Tanespimycin was administered at a dose of 450 mg/m2 following administration of the standard dose of trastuzumab.

Of 31 patients enrolled in the trial, 27 were evaluable for efficacy (as of May 15, 2008).
-- Of the 27 patients evaluable for efficacy, 17 (63%) showed

evidence of clinical benefit, including:

-- 7 patients or 26% had PR (including 1 patient with an unconfirmed

PR who remains on study)

-- 5 patients or 19% had tumor regressions (20-29% decrease)

-- 5 patients or 19% had SD of
'/>"/>

SOURCE Kosan Biosciences Incorporated
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6

Related medicine technology :

1. NexGenix Pharmaceuticals Presents Data on a Novel Small Molecule Inhibitor of Heat Shock Protein 90 (Hsp90) at the GTCbio Cancer Drugs Research & Development Conference
2. Kosan Initiates Phase 2 Trial of Alvespimycin, Second-Generation Hsp90 Inhibitor, in HER2-Positive Metastatic Breast Cancer
3. Kosan Presents Updated Data on Hsp90 Inhibitor, Tanespimycin, in Multiple Myeloma at Ash
4. First High-Res 3-D Structures of Mammalian HSP90 Protein Solved, Key to Better Targets for AIDS, Sepsis, Cancer Drugs
5. Kosans Second-Generation Hsp90 Inhibitor, Alvespimycin, Shows 42% Clinical Benefit in Phase 1 HER2-Positive Metastatic Breast Cancer Trial
6. Kosan Opens Registration Program for Lead Hsp90 Inhibitor, Tanespimycin, in Multiple Myeloma
7. BiPar Sciences Expands Clinical Development of BSI-201, A Novel PARP Inhibitor, With Phase 2 Trial in Uterine Cancer
8. BiPar Sciences Announces Clinical Data Presentations on Lead PARP Inhibitor, BSI-201, at 40th American Society of Clinical Oncology Annual Meeting
9. BiPar Sciences Expands Phase 2 Clinical Trials of BSI-201, a Novel DNA Repair Inhibitor, in Ovarian Cancer
10. SuperGen Identifies Lead PIM Kinase Inhibitor, SGI-1776, That Causes Tumor Regression in AML Xenograft Models
11. SuperGens DNA Methyltransferase Inhibitor, S-110, Improves In Vivo Efficacy Profile of Decitabine
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/23/2014)... NORWALK, Conn. , July 23, 2014 ... NeurologyTimes.com – a new online community and information ... them better manage and treat their patients with ... conditions, coupled with an aging population, necessitates greater access ... specific disorders.  Key statistics on neurological conditions include: ...
(Date:7/23/2014)... , July 23, 2014 Pharmavite LLC announced ... chief customer officer effective immediately. Toll recently served as ... and marketing, category management, private label and sales administration ... his new global role, Toll will expand his responsibilities ... planning. "Toll,s appointment to chief customer officer ...
(Date:7/23/2014)... July 23, 2014 Research and ... "Global Electrophysiology Ablation Catheters Market 2014-2018" ... http://photos.prnewswire.com/prnh/20130307/600769 Catheter ablation is ... destroy faulty electrical pathways from sections of the ... as cardiac arrhythmias). Cardiac arrhythmias can be of ...
Breaking Medicine Technology:UBM Medica US Launches NeurologyTimes.com 2UBM Medica US Launches NeurologyTimes.com 3Global Electrophysiology Ablation Catheters Market 2014-2018: Key Vendors are Boston Scientific, Johnson & Johnson, Medtronic and St. Jude Medical 2Global Electrophysiology Ablation Catheters Market 2014-2018: Key Vendors are Boston Scientific, Johnson & Johnson, Medtronic and St. Jude Medical 3
... March 16, 2011 /PRNewswire-Asia-FirstCall/ -- ... "Company") (Nasdaq: CMED ... in-vitro diagnostic ("IVD") company, today ... investors at the following investor ...
... SHENZHEN, China, March 16, 2011 /PRNewswire-Asia-FirstCall/ -- China Nepstar Chain ... Company"), the largest retail drugstore chain in China based on ... financial results for the fourth quarter and fiscal year ended ... HighlightsFor the quarter ended December 31, 2010: Same ...
Cached Medicine Technology:China Medical Technologies to Meet Investors 2China Nepstar Chain Drugstore Reports Fourth Quarter and Fiscal Year 2010 Financial Results 2China Nepstar Chain Drugstore Reports Fourth Quarter and Fiscal Year 2010 Financial Results 3China Nepstar Chain Drugstore Reports Fourth Quarter and Fiscal Year 2010 Financial Results 4China Nepstar Chain Drugstore Reports Fourth Quarter and Fiscal Year 2010 Financial Results 5China Nepstar Chain Drugstore Reports Fourth Quarter and Fiscal Year 2010 Financial Results 6China Nepstar Chain Drugstore Reports Fourth Quarter and Fiscal Year 2010 Financial Results 7China Nepstar Chain Drugstore Reports Fourth Quarter and Fiscal Year 2010 Financial Results 8China Nepstar Chain Drugstore Reports Fourth Quarter and Fiscal Year 2010 Financial Results 9China Nepstar Chain Drugstore Reports Fourth Quarter and Fiscal Year 2010 Financial Results 10China Nepstar Chain Drugstore Reports Fourth Quarter and Fiscal Year 2010 Financial Results 11China Nepstar Chain Drugstore Reports Fourth Quarter and Fiscal Year 2010 Financial Results 12
(Date:7/23/2014)... WEDNESDAY, July 23, 2014 (HealthDay News) -- Painful or ... skin cancer, researchers report. "Patients sometimes have multiple ... itchy or painful should raise high concerns for non-melanoma ... dermatology at Temple University School of Medicine, said in ... looked at the medical records of 268 patients who ...
(Date:7/23/2014)... Officials from China,s Northwest Agricultural and Forestry University in ... signed a memorandum of agreement that lays the groundwork ... Safety in China. , The signing ceremony was held ... between high-level officials of the U.S. Department of Agriculture ... agreement is a landmark event for UC Davis and ...
(Date:7/23/2014)... The American Telemedicine Association (ATA) ... annual meeting and tradeshow focused exclusively on telemedicine, ... over 5,000 attendees and more than 250 cutting-edge ... 2015, in Los Angeles. , ATA’s annual meeting ... from researchers, clinicians, hospital and university administrators, program ...
(Date:7/23/2014)... 23, 2014 Bodybuilding.com, the Internet’s most-visited ... of nutritional supplements, has officially opened the polls for ... , the fastest growing sports nutrition company, is up ... of the Year, Best Tasting Protein of the Year- ... of the year - Whey-HD™, Pre-workout Supplement of the ...
(Date:7/23/2014)... The voice on the recording was low and ... news he was infected with the human immunodeficiency virus (HIV) that ... next thing you know I was on the floor flat on ... was hopeful when the recording ended less than 10 minutes later. ... . because it is just God setting you up for ...
Breaking Medicine News(10 mins):Health News:Painful, Itchy Patches Could Be Sign of Skin Cancer 2Health News:Global food safety research agreement signed by China and UC Davis 2Health News:Global food safety research agreement signed by China and UC Davis 3Health News:ATA Seeks Speakers to Present at the World’s Largest Telemedicine, mHealth and Telehealth Conference 2Health News:Vote Now; BPI SPORTS is Nominated for Eight 2014 Bodybuilding.com Supplement Awards 2Health News:Vote Now; BPI SPORTS is Nominated for Eight 2014 Bodybuilding.com Supplement Awards 3Health News:HIV clinic-based audio project emphasizes the power of patient voices 2Health News:HIV clinic-based audio project emphasizes the power of patient voices 3
... Trust for America,s Health (TFAH) ... today entitled Health Care vs. Sick Care. , ... chance to transform our health care system from a sick ... Jeff Levi, PhD, Executive Director of TFAH. "The evidence is ...
... Oct. 28 The cutting-edge of assistive technology--including ... showcased at the Assistive Technology Pavilion at Abilities ... 6-8, 2009 at the Cobb Galleria Convention Center. ... caregivers and healthcare professionals are expected to attend ...
... Inc. (TSX: NRI), a Canadian drug development company focused on ... to and through the skin using its topical and transdermal ... its immune modulating drug candidate, WF10, today announced its financial ... , , Reent Corporate Developments:, ...
... ... digital radiology laboratory, Spencer Peller of 123Chiropractors.com presents the donation check to Life West ... ... November 3, 2009 -- 123Chiropractors.com, http://www.123chiropractors.com , the world,s largest portal relating to ...
... TORONTO, Oct. 28 /PRNewswire/ - LPBP Inc. (the ... 2009 press release related to the per share ... The per share dividend on the Class B ... on the Class A Common shares of $0.0099 ...
... to examine how physicians care for patients from diverse ... Oct. 28 Connecticut physicians believe they could be ... and ethnic backgrounds if they had training that was ... released today by the Connecticut State Medical Society. ...
Cached Medicine News:Health News:New Health Care vs. Sick Care Ad Campaign Launched by Trust for America's Health and Partnership for Prevention 2Health News:New Health Care vs. Sick Care Ad Campaign Launched by Trust for America's Health and Partnership for Prevention 3Health News:Experience the Future of Assistive Technology at Abilities Expo on November 6-8, 2009 2Health News:Nuvo announces 2009 third quarter financial results 2Health News:Nuvo announces 2009 third quarter financial results 3Health News:Nuvo announces 2009 third quarter financial results 4Health News:Nuvo announces 2009 third quarter financial results 5Health News:Nuvo announces 2009 third quarter financial results 6Health News:Nuvo announces 2009 third quarter financial results 7Health News:Nuvo announces 2009 third quarter financial results 8Health News:Nuvo announces 2009 third quarter financial results 9Health News:Nuvo announces 2009 third quarter financial results 10Health News:Nuvo announces 2009 third quarter financial results 11Health News:Nuvo announces 2009 third quarter financial results 12Health News:World's Largest Resource for and about Chiropractors, 123Chiropractors.com, Donates $15,000 to Life Chiropractic College West 2Health News:World's Largest Resource for and about Chiropractors, 123Chiropractors.com, Donates $15,000 to Life Chiropractic College West 3Health News:CSMS Issues Results of Health Disparities Survey 2
The Snap-In Snap-Out-II Tip Inserts offer a large variety of configurations....
The Optima III 45 cm line of laparoscopic hand instruments is ideal for operative laparoscopic/endoscopic procedures or when a longer instrument is needed....
The ACMI™ line of laparoscopic hand instruments is designed to provide a wide selection of popular surgical devices to meet procedural needs....
Insulated, angled, spoon-shaped design cups the gallbladder, permits clear visualization, and allows easy dissection and control of bleeders....
Medicine Products: