Navigation Links
Kosan Presents Updated Data on Hsp90 Inhibitor, Tanespimycin, in Multiple Myeloma at Ash
Date:12/8/2007

ompare three different dose groups of tanespimycin (50, 175 and 340 mg/m2), each in combination with bortezomib (1.3 mg/m2). Eligible patients must have failed three prior multiple myeloma regimens, including one each of bortezomib and lenalidomide (Revlimid(R)). The primary endpoint is objective response rate.

TIME-1 is designed as a Phase 3 trial in patients with disease relapse following a single prior course of treatment (first-relapse). TIME-1 is planned to be a randomized, open-label, multi-center international trial with a primary endpoint of progression free survival (PFS), comparing two groups: patients treated with bortezomib plus tanespimycin (dosed at 340 mg/m2) and patients treated with bortezomib alone. The primary endpoint is designed to be progression-free survival.

About Kosan

Kosan Biosciences is a biotechnology company advancing two new classes of anticancer agents through clinical development -- Hsp90 (heat shock protein 90) inhibitors and epothilones. Kosan is leveraging its proprietary discovery platform to generate a pipeline of potentially significant product candidates, primarily in the area of oncology.

Hsp90 inhibitors have a novel mechanism of action targeting multiple pathways involved in cancer cell growth and survival. Tanespimycin (KOS-953) is being tested in combination with bortezomib (Velcade(R)) in patients with multiple myeloma in a registration program called TIME. Tanespimycin is also being studied in HER2-positive metastatic breast cancer in combination with trastuzumab (Herceptin(R)), and as monotherapy in metastatic melanoma. Intravenous and oral formulations of Kosan's second-generation Hsp90 inhibitor, alvespimycin (KOS-1022), are being evaluated in Phase 1 clinical trials in hematologic and solid tumors and in HER2-positive metastatic breast cancer.

Epothilones inhibit cell division through a mechanism of action similar to taxanes, one of the most successful classes of anti-tumor agents.
'/>"/>

SOURCE Kosan Biosciences Incorporated
Copyright©2007 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6

Related medicine technology :

1. Kosans Motilin Receptor Agonist, Licensed to Pfizer, Enters Phase 1 Clinical Trial in Gastroesophageal Reflux Disease
2. Kosan Opens Registration Program for Lead Hsp90 Inhibitor, Tanespimycin, in Multiple Myeloma
3. Kosan Receives Completed Special Protocol Assessment for TIME-1 Pivotal Phase 3 Trial of Tanespimycin in Multiple Myeloma
4. Kosans Second-Generation Hsp90 Inhibitor, Alvespimycin, Shows 42% Clinical Benefit in Phase 1 HER2-Positive Metastatic Breast Cancer Trial
5. Kosan Presents Phase 1 Data Showing Antitumor Activity and Safety Profile of Epothilone KOS-1584 at AACR/NCI/EORTC Meeting
6. Genaera Corporation Presents Interim Phase 1 Data for Obesity Compound Trodusquemine (MSI-1436) at IBC Conference
7. EntreMed Presents Data for Phase 2 Study of MKC-1 in Metastatic Breast Cancer
8. Pharmasset Presents R7128 Phase 1 Single Ascending Dose Study in Healthy Volunteers
9. Anadys Pharmaceuticals Presents Preclinical Results on ANA598, a Non-Nucleoside Inhibitor of the NS5B Polymerase, at the 14th International Symposium on Hepatitis C Virus and Related Viruses
10. CEL-SCI Presents Data for CEL-1000 as a Vaccine Adjuvant with Recombinant Hepatitis B Virus Protein
11. Ardea Biosciences, Inc. Presents Results of Phase 1 Studies of RDEA806, a Novel NNRTI for HIV, at 47th ICAAC
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/27/2014)... YORK , Aug. 27, 2014 ... is available in its catalogue: Global ... http://www.reportlinker.com/p02316641/Global-Animal-Health-Market-2014-2018.html About Animal Health Animal ... animal diseases or treat animals to enhance their ... the yield of animal food. The Global Animal ...
(Date:8/27/2014)... Kewaunee Scientific Corporation (Nasdaq: KEQU ... quarterly cash dividend by 9% to twelve cents per ... with the dividend payable on September 22, 2014 to ... September 8, 2014. About Kewaunee Scientific ... Corporation is a recognized global leader in the design, ...
(Date:8/27/2014)... Conn. , Aug. 27, 2014  UBM Medica ... a leading online community for medical imaging professionals, presents ... Association for Medical Imaging Management,s 2014 Annual Meeting . ... conference coverage: , 11 Principles of ... can lead to greater profitability. , Why ...
Breaking Medicine Technology:Global Animal Health Market 2014-2018 2Global Animal Health Market 2014-2018 3Global Animal Health Market 2014-2018 4Global Animal Health Market 2014-2018 5Global Animal Health Market 2014-2018 6Global Animal Health Market 2014-2018 7Diagnostic Imaging Covers Association for Medical Imaging Management (AHRA) 2014 Meeting 2Diagnostic Imaging Covers Association for Medical Imaging Management (AHRA) 2014 Meeting 3
... Generex Biotechnology Corporation (Nasdaq: GNBT ; ... diseases through the inner lining of the mouth, announced ... Licensing & Distribution Agreement with PMG S.A. ( www.pmgpharma.com ... Generex Oral-lyn™, the Company,s proprietary buccal insulin spray product, ...
... Corporation, a privately-held biotechnology company focused on developing a ... announced that Quinton Oswald has joined the company as ... significant commercial experience and management expertise to the CEO ... the Vice President & Business Unit Head for the ...
Cached Medicine Technology:Generex Announces Distribution Agreement for Generex Oral-lyn™ in Chile 2Generex Announces Distribution Agreement for Generex Oral-lyn™ in Chile 3Quinton Oswald Named Chief Executive Officer of SARcode Corporation 2Quinton Oswald Named Chief Executive Officer of SARcode Corporation 3
(Date:8/28/2014)... 28, 2014 Top 10 Best ... hosting companies and announces Bluehost, HostMonster ( http://www.hostmonster.com/track/seohosts ... for the webmasters worldwide who want to buy ... As the world’s most popular server-side scripting language, ... other general-purpose programs. It is now installed on ...
(Date:8/28/2014)... MMAR Medical is pleased to announce their Customer ... customers to enjoy several perks and benefits when shopping ... license. It’s a great choice for independent athletes, high ... regularly purchase medical braces but could use a discounted ... lifestyle or those of your club, group or team, ...
(Date:8/28/2014)... 2014 On September 1st, the National ... campaign. The goal is to help families and ... and effectively and without exposures to risky pesticides. ... “Children’s exposures to pesticides should be limited as ... Head lice are often trivialized in the media, which ...
(Date:8/27/2014)... A St. Louis law firm that represents ... that the C.R. Bard multidistrict litigation (MDL), an MDL ... lawsuits, recently filed a new pretrial order (PTO) on ... discovery process, and more specifically to the management of ... & Lowe is a law firm practicing defective medical ...
(Date:8/27/2014)... August 27, 2014 DentistSave.com ... plans, has launched in the state of Tennessee ... quality, affordable dental care services at reduced rates. ... Tennessee consumers looking to save money on their ... as a member of discount fee dental plan ...
Breaking Medicine News(10 mins):Health News:MMAR Medical Announces Customer Membership Program 2Health News:Head Lice Can Be a Public Health Opportunity 2Health News:Head Lice Can Be a Public Health Opportunity 3Health News:Head Lice Can Be a Public Health Opportunity 4Health News:Carey Danis & Lowe Reports On New Court Order in C.R. Bard Transvaginal Mesh MDL 2Health News:DentistSave.com Launches Discount Dental Plans in Tennessee for Consumers, Businesses, and Groups 2Health News:DentistSave.com Launches Discount Dental Plans in Tennessee for Consumers, Businesses, and Groups 3
... poor balance, dementia, vision loss most in peril, group says ... people are at high risk for accidental falls and should ... fall-related injuries and deaths in the United States, a new ... falls result in 1.8 million emergency room visits and more ...
... NEW YORK, Feb 4 March of Dimes New York ... as the,official Celebrity Chairman for March for Babies(SM) in New ... March of Dimes,premier fundraising event that benefits all babies-those born ... thrive., "I,m proud to be partnering with March of ...
... The Presidents proposed budget for fiscal year 2009, if ... by extension, our national effort to respond to the ... The Administrations budget flat-funds critical federal support for research ... programs at the Centers for Disease Control and Prevention ...
... FY 2009 Budget Blueprint ,Most Unreasonable, Most Unrealistic, ... Reacting to the formal,unveiling of the Bush ... Association (AHCA) said the proposal is unreasonable from ... in the face of worsening economic conditions in ...
... Clinic to Automate Three Offices with High Performance DR ... ... /PRNewswire-FirstCall/ - IDC (Imaging Dynamics Company,Ltd.) (TSX: IDL), the global leader ... a contract by,Orthopaedic Clinic of Daytona Beach in Florida for four ...
... Concludes (Again) That Antitrust Exemptions Increase Costs, ... (PCMA) issued the following statement in response to,the ... (S.B.,2190) that would allow individual and corporate health ... charge higher fees:, "This latest comment from ...
Cached Medicine News:Health News:New Guideline Urges Screening for Fall Risk 2Health News:Eli Manning Teams Up with March of Dimes in New York City 2Health News:2009 Bush budget a disaster for HIV/AIDS 2Health News:Bush Budget Represents 'Double Whammy' Hit on U.S. Seniors' Medicare-Financed Nursing Facility Care 2Health News:Orthopaedic Clinic of Daytona Beach Chooses IDC for Transition to Digital X-ray 2
The High Pure Viral RNA Kit is intended for general laboratory use and is designed to purify viral RNA from serum or plasma. Viral RNA is used for RT-PCR analysis directly after elution in nuclease-f...
... This revolutionary product will provide you ... type of electroretinogram, visual evoked potential, ... ganzfeld will allow you to perform ... on-off, double flash, photopic negative response, ...
The PersonalLAB junior is an automated microplate analyzer capable of fully automating immunoenzymatic techniques using a microplate format, per the reagent manufacturer's instruction for use and spe...
... is designed for high throughput microplate processing. ... S60 Stacker that handles up to 60 ... base model is equipped with a dual ... units may be interfaced to increase flexibility ...
Medicine Products: