Navigation Links
Kosan Presents Updated Data on Hsp90 Inhibitor, Tanespimycin, in Multiple Myeloma at Ash
Date:12/8/2007

tanespimycin, and from 0.7-1.3 mg/m2 for bortezomib. Activity was evaluated in patients that were bortezomib-naive, bortezomib-pretreated and bortezomib-refractory (defined as no response on prior bortezomib-containing regimens or progression on or within 60 days of a bortezomib-containing regimen). Patients received tanespimycin by a 1-hour infusion following the bortezomib dose 2 times per week every 2 weeks out of 3 weeks.

A total of 71 patients were enrolled in the trial: 30 patients in the dose-escalating phase and 41 patients treated at 340 mg/m2 of tanespimycin and 1.3 mg/m2 of bortezomib. Of the 41 patients in the 340 mg/m2 of tanespimycin and 1.3 mg/m2 of bortezomib dose group, 19 were treated with the prior Cremophor-containing formulation of tanespimycin (tanespimycin injection) and 22 were treated with the recently introduced tanespimycin injectable suspension formulation (52 evaluable total). As objective responses were observed across the multiple dose levels, the data at ASH were presented on an overall basis.

In the bortezomib-naive group, the overall response rate (complete, partial and minor responses) was 47% (9 out of 19 evaluable patients), including 2 complete responses (CR), 1 near-complete response, 2 partial responses (PR) and 4 minor responses (MR). The response rates were similar between the tanespimycin injection (45%, 5 out of 11 patients; 2 CR, 1 PR, 2 MR) and the injectable suspension (50%, 4 out of 8 patients; 1 CR, 1PR, 2 MR) groups.

In the bortezomib-pretreated group, the overall response rate was 47% (7 out of 15 evaluable patients; 1 CR, 2 PR, 4 MR). In this group, 14 patients received the Cremophor-containing formulation and 1 patient received the injectable suspension formulation.

In the bortezomib-refractory group, the overall response rate was 17% (3 out of 18 evaluable patients; 3 PR). All responding bortezomib-refractory patients received the Cremophor-containing formulation. Five patients receiv
'/>"/>

SOURCE Kosan Biosciences Incorporated
Copyright©2007 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6

Related medicine technology :

1. Kosans Motilin Receptor Agonist, Licensed to Pfizer, Enters Phase 1 Clinical Trial in Gastroesophageal Reflux Disease
2. Kosan Opens Registration Program for Lead Hsp90 Inhibitor, Tanespimycin, in Multiple Myeloma
3. Kosan Receives Completed Special Protocol Assessment for TIME-1 Pivotal Phase 3 Trial of Tanespimycin in Multiple Myeloma
4. Kosans Second-Generation Hsp90 Inhibitor, Alvespimycin, Shows 42% Clinical Benefit in Phase 1 HER2-Positive Metastatic Breast Cancer Trial
5. Kosan Presents Phase 1 Data Showing Antitumor Activity and Safety Profile of Epothilone KOS-1584 at AACR/NCI/EORTC Meeting
6. Genaera Corporation Presents Interim Phase 1 Data for Obesity Compound Trodusquemine (MSI-1436) at IBC Conference
7. EntreMed Presents Data for Phase 2 Study of MKC-1 in Metastatic Breast Cancer
8. Pharmasset Presents R7128 Phase 1 Single Ascending Dose Study in Healthy Volunteers
9. Anadys Pharmaceuticals Presents Preclinical Results on ANA598, a Non-Nucleoside Inhibitor of the NS5B Polymerase, at the 14th International Symposium on Hepatitis C Virus and Related Viruses
10. CEL-SCI Presents Data for CEL-1000 as a Vaccine Adjuvant with Recombinant Hepatitis B Virus Protein
11. Ardea Biosciences, Inc. Presents Results of Phase 1 Studies of RDEA806, a Novel NNRTI for HIV, at 47th ICAAC
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/2/2015)... 2015 San MediTech, the industry leader in ... (CGM) for diabetics, announced its plan to attend the ... Boston on June 5 th ... Glucose Monitoring System (DGMS). The company plans to show ... innovative technologies and advancements made by Chinese medical device ...
(Date:6/2/2015)... , June 2, 2015  CytRx Corporation (NASDAQ: ... in oncology, today announced that it has reached an ... the Delaware Court of Chancery, ... current and former directors and officers, and names the ... captioned In re CytRx Corp. Stockholder Derivative Litigation ...
(Date:6/2/2015)... , June 02, 2015 Research ... addition of the "Electrophysiology Market by Product ... RF, Microwave), Lab Devices (Mapping, Recording, Generator, ICE, ... Forecasts to 2019" report to their offering. ... estimated to grow at a significant CAGR of ...
Breaking Medicine Technology:San MediTech Showcases Smart Glucose Management Cloud Database at 75th ADA 2San MediTech Showcases Smart Glucose Management Cloud Database at 75th ADA 3San MediTech Showcases Smart Glucose Management Cloud Database at 75th ADA 4CytRx Announces Settlement of Stockholder Derivative Lawsuit in Delaware 2CytRx Announces Settlement of Stockholder Derivative Lawsuit in Delaware 3CytRx Announces Settlement of Stockholder Derivative Lawsuit in Delaware 4Global Electrophysiology Market Report 2015-2019 - Product, Ablation Catheter, Lab Devices & Indication Analysis 2Global Electrophysiology Market Report 2015-2019 - Product, Ablation Catheter, Lab Devices & Indication Analysis 3
(Date:6/2/2015)... 02, 2015 The 3TVPhoenix contest, conducted in ... the station’s 6:00 a.m. Good Morning Arizona program for a ... station’s Facebook page. , Lisa Allen of Scottsdale ... She plans to apply the monthly $1,000 prize to her ... stay-at-home mom, expressed her surprise and gratitude at winning, indicating ...
(Date:6/2/2015)... 2015 The term “Augmented Reality” was ... overlaid on the real world. Since then many promising ... displays a map of the vasculature on the surface ... adoption. , AccuVein, the leader in vein visualization, exemplifies ... rate and such widespread adoption of its AccuVein AV400 ...
(Date:6/2/2015)... York, NY (PRWEB) June 02, 2015 ... Profemur hip replacement lawsuit ( http://www.consumerinjurylawyers.com/wright-profemur-hip-replacement ) is ... County. According to court documents, opening statements were ... asserting that laser etchings on the Profemur hip ... fracture, causing it to snap just three years ...
(Date:6/2/2015)... TMG Health, the leading national provider ... the Medicare Advantage, Medicare Part D, and Managed Medicaid ... at AHIP’s Institute 2015, the annual meeting of the ... will be held June 3-5 in Nashville, Tenn. , ... for attendees to schedule private discussions with senior members ...
(Date:6/2/2015)... Did you wish Ryder Weise a happy sixth birthday ... isn’t asking for presents, but instead a donation to the ... HHT DC Walk. , Ryder was diagnosed with HHT in ... leading to sudden and extreme bleeding throughout the body. Though ... years old in the form of daily nosebleeds, fatigue and ...
Breaking Medicine News(10 mins):Health News:Scottsdale Resident Named $12,000 Prize Winner- Arizona Central and KTVK 3TV Phoenix Partner in Mortgage Giveaway Contest 2Health News:Vein Visualization Emerges as Premier Augmented Reality Application 2Health News:First of More Than 1,200 Wright Hip Lawsuits Goes to Trial in California Superior Court 2Health News:First of More Than 1,200 Wright Hip Lawsuits Goes to Trial in California Superior Court 3Health News:TMG Health to Sponsor and Exhibit at AHIP’s Institute 2015 2Health News:Six-Year-Old Walks to Bring Awareness to Genetic Disease 2
... celebrating his one Year Anniversary as a Non-Smoker 60 Pounds Lighter. What ... quit smoking or lose 60 pounds but to do both within one year ... was able to turn his life around and improve his quality of life; ... , ...
... voice preference on two California reorganization plans , ... members began casting ballots this week in an advisory vote ... register their preferences on whether they want to be part ... a new statewide local representing a broader classification of healthcare ...
... County Health Director, Dr. Bob England Encourage all Families to ... One Middle School , , ... that Arizona has its first lab-confirmed case of influenza in ... Public Health, the Arizona Department of Health Services, the Arizona ...
... announced today the Company will hold an,investor conference call to discuss current business conditions ... is,(866) 901-2585. The international call in number is (404) 835-7099. , , ... & ... ctrego@minrad.com , ...
... Consulting Inc.,announces the addition of two new areas of ... engineering and technology,services. The company is also launching its ... The company has realigned its services into ... sustainability. , "We ...
... useful, studies find , , WEDNESDAY, Nov. 19 (HealthDay News) -- ... diabetes was no better at predicting a person,s risk for ... , The news is both encouraging and discouraging. , "The ... risk," said Dr. James Meigs, lead author of one of ...
Cached Medicine News:Health News:Former Smoker Celebrates One Year Anniversary of Being a Non-Smoker 60 Pounds Lighter 2Health News:Former Smoker Celebrates One Year Anniversary of Being a Non-Smoker 60 Pounds Lighter 3Health News:Advisory Vote Begins on California Long-Term Care Local 2Health News:American Lung Association of Arizona, Phoenix Fire and Maricopa County Public Health Urge Residents to Get Vaccinated Against the Flu 2Health News:American Lung Association of Arizona, Phoenix Fire and Maricopa County Public Health Urge Residents to Get Vaccinated Against the Flu 3Health News:American Lung Association of Arizona, Phoenix Fire and Maricopa County Public Health Urge Residents to Get Vaccinated Against the Flu 4Health News:Environmental and Technology Firm Integral Consulting Inc. Expands Services, Launches New Website 2Health News:Genetic Testing No Real Help in Predicting Type 2 Diabetes 2Health News:Genetic Testing No Real Help in Predicting Type 2 Diabetes 3
... vision controls all refractor operations ... from the wireless remote control. ... can be loaded into the ... transfer. The illuminated LED heads-up ...
... testing provides clinically beneficial information in ... Dark adaptometry is useful in the ... senile miosis, high myopia, vitamin-A deficiency, ... whole-field scotopic sensitivity has been shown ...
... The UTAS-E 3000 is the most ... rapid and accurate measurements of retinal ... comprehensive, easy-to-use software available drives this ... such as adjustable contrast pattern stimulation, ...
The STALIF stand-alone anterior lumbar fusion cage is the latest product development from Surgicraft. STALIF is the natural evolution of the Hartshill Horseshoe, which has over 10 years clinical suc...
Medicine Products: