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Kosan Presents Updated Data on Hsp90 Inhibitor, Tanespimycin, in Multiple Myeloma at Ash
Date:12/8/2007

tanespimycin, and from 0.7-1.3 mg/m2 for bortezomib. Activity was evaluated in patients that were bortezomib-naive, bortezomib-pretreated and bortezomib-refractory (defined as no response on prior bortezomib-containing regimens or progression on or within 60 days of a bortezomib-containing regimen). Patients received tanespimycin by a 1-hour infusion following the bortezomib dose 2 times per week every 2 weeks out of 3 weeks.

A total of 71 patients were enrolled in the trial: 30 patients in the dose-escalating phase and 41 patients treated at 340 mg/m2 of tanespimycin and 1.3 mg/m2 of bortezomib. Of the 41 patients in the 340 mg/m2 of tanespimycin and 1.3 mg/m2 of bortezomib dose group, 19 were treated with the prior Cremophor-containing formulation of tanespimycin (tanespimycin injection) and 22 were treated with the recently introduced tanespimycin injectable suspension formulation (52 evaluable total). As objective responses were observed across the multiple dose levels, the data at ASH were presented on an overall basis.

In the bortezomib-naive group, the overall response rate (complete, partial and minor responses) was 47% (9 out of 19 evaluable patients), including 2 complete responses (CR), 1 near-complete response, 2 partial responses (PR) and 4 minor responses (MR). The response rates were similar between the tanespimycin injection (45%, 5 out of 11 patients; 2 CR, 1 PR, 2 MR) and the injectable suspension (50%, 4 out of 8 patients; 1 CR, 1PR, 2 MR) groups.

In the bortezomib-pretreated group, the overall response rate was 47% (7 out of 15 evaluable patients; 1 CR, 2 PR, 4 MR). In this group, 14 patients received the Cremophor-containing formulation and 1 patient received the injectable suspension formulation.

In the bortezomib-refractory group, the overall response rate was 17% (3 out of 18 evaluable patients; 3 PR). All responding bortezomib-refractory patients received the Cremophor-containing formulation. Five patients receiv
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SOURCE Kosan Biosciences Incorporated
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