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Kosan Presents Preclinical Data on Nuclear Export Inhibitors, Novel Anticancer Agents, at AACR
Date:4/16/2008

HAYWARD, Calif., April 16 /PRNewswire-FirstCall/ -- Kosan Biosciences Incorporated (Nasdaq: KOSN) presented preclinical data on its proprietary nuclear export inhibitors (NEI) showing potent in vitro and in vivo activity as well as tolerability in leukemia xenograft models, and further elucidating the NEI anticancer mechanism of action correlating inhibition of the target CRM1 with induction of apoptosis selectively in cancer cells compared to normal cells. Data on Kosan's NEIs were presented at the 2008 Annual Meeting of the American Association for Cancer Research (AACR), being held in San Diego, CA.

Kosan's NEIs are potent, specific inhibitors of CRM1, a highly conserved, essential protein that exports key regulatory proteins ("cargo" proteins) from the nucleus to the cytoplasm. Many cargo proteins that depend on CRM1 for nuclear export, such as p53, Bcr-Abl and FOXO-3a, function as tumor suppressors or transcription factors that protect normal cells by regulating cell growth and apoptosis (cell death). Accumulation of these CRM1 cargo proteins in the nucleus, by blocking nuclear export, leads to the inhibition of cell growth and apoptosis selectively in cancer cells. Kosan's polyketide-based NEI compounds have optimized pharmaceutical properties, including potency, durability of action and a wide therapeutic index.

"Kosan's NEI preclinical compounds continue to demonstrate attractive biological and pharmacological properties and potent anticancer activity and tolerability in both solid and liquid tumors," said Helen S. Kim, Kosan's President and Chief Executive Officer. "We are currently seeking a development partner for our NEI program, as we believe that the optimal strategy for continuing to explore the therapeutic ut
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SOURCE Kosan Biosciences Incorporated
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