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Kosan Opens Registration Program for Lead Hsp90 Inhibitor, Tanespimycin, in Multiple Myeloma
Date:8/19/2007

Tanespimycin is Industry's First Hsp90 Inhibitor to Enter Registration

Program

TIME Registration Program Utilizes New, Proprietary Tanespimycin

Formulation

HAYWARD, Calif., Aug. 2 /PRNewswire-FirstCall/ -- Kosan Biosciences Incorporated (Nasdaq: KOSN) today announced that the TIME-2 trial is open and enrolling patients. This marks the opening of Kosan's Tanespimycin in Myeloma Evaluation or "TIME" registration program for its lead Hsp90 inhibitor, tanespimycin (KOS-953). The TIME program includes two clinical trials: TIME-1 and TIME-2. TIME-1 is a pivotal Phase 3 trial to be conducted in a first-relapse patient population. TIME-2, which is designed to be supportive of the TIME-1 trial, is a Phase 2/3 trial in patients with relapsed-refractory disease. TIME-2 also has the potential to support registration in a relapsed-refractory setting. The TIME program will use Kosan's new, proprietary injectable suspension formulation of tanespimycin. Tanespimycin is the first Hsp90 inhibitor to enter a registration program.

"The opening of our TIME registration program is a major achievement for our company and a milestone in the advancement of Hsp90 inhibition, a promising new approach to cancer therapy," said Robert G. Johnson, Jr., M.D., Ph.D., Kosan's President and Chief Executive Officer. "We continue to be encouraged by the high level of durable responses we observe when tanespimycin combined with bortezomib (Velcade(R)) is administered to patients with relapsed-refractory multiple myeloma, as well as by tanespimycin's manageable safety profile. We believe that a successful outcome in the TIME-2 trial, together with data from our TIME-1
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SOURCE Kosan Biosciences Incorporated

Copyright©2007 PR Newswire.

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