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Kinex Pharmaceuticals and Zenith Technology Corporation announce the execution of a collaborative licensing agreement
Date:5/6/2013

BUFFALO, N.Y., May 6, 2013 /PRNewswire/ -- Kinex Pharmaceuticals and Zenith Technology Corporation, through its affiliate ZenRx, announced today the execution of a collaborative licensing agreement granting Zenith Technology commercial rights to Oraxol and Oratecan in New Zealand and Australia.  ZenRx will provide an upfront payment, milestones and royalties.  Importantly, Zenith Technology Corporation will commit a significant amount of resources to the Oraxol and Oratecan global development programs, providing Kinex and its Asian partner, Hanmi Pharmaceuticals (Seoul, South Korea) additional clinical programs, supporting global registrations in a non-dilutive fashion.

In December 2011, Kinex Pharmaceuticals licensed the global rights in certain territories outside of Korea, China, India, and Japan, to develop and commercialize the Orascovery program from Hanmi Pharmaceutical Company.  The program is based on an important platform technology developed by Hanmi Pharmaceuticals, compound HM30181A, a potent and selective P-glycoprotein (PGP) pump inhibitor.  Suppression of the PGP pump allows certain clinically important compounds (such as Paclitaxel and Irinotecan, among others) which would normally be effluxed back into the gastrointestinal tract and excreted, to enter the bloodstream and be bioavailable through oral administration.  Importantly, HM30181A is a very effective PGP inhibitor that is not systemically absorbed.

The Orascovery technology has led to the initiation of trials being conducted with both an oral formulation of paclitaxel (Oraxol), currently in Phase II clinical trials in Korea, and an oral formulation of Irinotecan (Oratecan), which has completed a Phase I clinical trial in Korea. Additional trials are being planned in both Korea and t
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