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Kinex Pharmaceuticals Will Take the Lead in the Orascovery Program Development in China
Date:7/9/2013

BUFFALO, N.Y., July 9, 2013 /PRNewswire/ -- Kinex Pharmaceuticals and Hanmi Pharmaceutical Co., Ltd. are pleased to announce the execution of an agreement for Kinex Pharmaceuticals to lead Orascovery program development in China. This further strengthens the existing agreement forged in December of 2011. Under the terms of the 2011 agreement, Kinex Pharmaceuticals acquired the rights to develop and commercialize all products derived from the Orascovery program for all indications in the United States, European Union, Eastern Europe, Russia, South America, Australia, New Zealand, Taiwan, and Hong Kong.

The Orascovery program is based on important platform technology initially developed by Hanmi Pharmaceutical, including compound HM30181A, which is a highly potent and selective P-glycoprotein (PGP) pump inhibitor. Suppression of the PGP pump in the gastrointestinal tract allows certain clinically important compounds, (such as paclitaxel and irinotecan, among others) which would normally be effluxed back into the gastrointestinal tract and excreted, to enter the bloodstream and be bioavailable through oral administration.  Importantly, HM30181A is a very effective PGP inhibitor that is not systemically absorbed. The current lead products include an oral formulation of paclitaxel, which is in Phase II clinical trials in Korea, and an oral formulation of irinotecan, which has just completed Phase I clinical trials in Korea.

Kinex Pharmaceuticals will assume all development responsibility in the licensed territories. Kinex and Hanmi will also work together to ensure that the product development in various geographic regions will complement each other in overall strategic global product
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