Navigation Links
Kinex Announces that the US FDA Allows their IND to Begin KX02 Clinical Trials
Date:6/4/2013

BUFFALO, N.Y., June 4, 2013 /PRNewswire/ -- Kinex Pharmaceuticals, Inc. announced today, that the FDA has allowed its Investigational New Drug (IND) application for KX02, Kinex's dual src/pretubulin inhibitor for the glioblastoma setting.   KX02 is partnered in the greater China territory with XiangXue Pharmaceuticals (300147.SZ) of Guangzhou, China.  KX02 is Kinex's second internally developed compound to enter clinical studies and Phase I clinical protocols are being finalized with the FDA.  Kinex's first internally developed compound, KX01, is currently in clinical trials in both the USA and Korea in a variety of indications.  In collaboration with Hanmi Pharmaceuticals, Oraxol and Oratecan are also in the clinic. Kinex has also recently partnered with ZenRx on the development of Oraxol and Oratecan in the New Zealand and Australia Territory.

KX02, a lipophilic dual src/pretubulin inhibitor, was discovered and developed by Kinex Pharmaceuticals through their internal R&D efforts.  It is a small molecule that has shown potent inhibitory activity against a broad panel of brain tumor cell lines, including cells (T98G) that are resistant to Temodar, the most widely used chemotherapy for the treatment of malignant glioma.  In a well-established brain tumor animal model, KX02 has been shown to consistently clear brain tumors after 4 weeks of therapy in 30-60% of treated animals.  Pharmacokinetic studies showed that KX02 is absorbed orally and has 76% penetration into brain tissue from plasma.  Mouse tumor model studies showed that KX02 induced more necrosis of the glioma compared to Temodar, and also engaged a durable immune response to the glioblastoma tumor cells.  The intellectual property of KX02 as a new chemical entity is protected by issued patents in the US,
'/>"/>

SOURCE Kinex Pharmaceuticals, Inc.
Copyright©2012 PR Newswire.
All rights reserved

Page: 1 2 3

Related medicine technology :

1. Kinex Pharmaceuticals and Zenith Technology Corporation announce the execution of a collaborative licensing agreement
2. Kinex Pharmaceuticals Chief Scientific Officer, Dr. David Hangauer, named the American Cancer Societys 2013 Honoree for its Cuisine for a Cure event
3. Hanmi and Kinex Announced Korean FDA Allowance of the KX01 IND Application
4. Kinex Pharmaceuticals Appoints Mr. Patrick Gallagher Vice President of Business Development and Investor Relations
5. Kinex Pharmaceuticals Receives Substantial Strategic Investment
6. Xiangxue Pharmaceuticals to Acquire Rights for a Promising Drug Candidate from Kinex Pharmaceuticals for the Greater China Territory
7. Cheetah Medical Announces New Management Team
8. Accelerate Diagnostics Announces Plans For Rights Offering To Stockholders
9. Array BioPharma Announces Proposed Public Offering of Convertible Debt
10. Gulf Coast Spine Care Announces New Neck Pain Treatments
11. HPN Announces Team POWERDOT Wins $500,000 As Current Leader
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/24/2014)... PLYMOUTH MEETING, Pa. , Nov. 24, 2014  Inovio ... Dr. J. Joseph Kim , President and CEO of ... board and management team to ring the Nasdaq Opening Bell ... celebration of Inovio,s September 15 th listing on the ... bell ringing ceremony, Dr. Kim said, "We are honored to ...
(Date:11/22/2014)... -- New data demonstrates that flibanserin, a novel, non-hormonal medicine ... sexual dysfunction, Hypoactive Sexual Desire Disorder (HSDD), does not ... women when taken at bedtime. The data was presented ... America,s (SMSNA) 20th Annual Fall Scientific Meeting ... SMSNA accepted this study as a late breaking abstract ...
(Date:11/22/2014)... 21, 2014 Statistics released from a number ... increase astronomically during the holidays, beginning with Thanksgiving eve, ... The data, highlighted in an ... as part of their annual Sober Days for ... of high-risk drinking and increased rates of DUI injuries ...
Breaking Medicine Technology:Inovio Pharmaceuticals to Ring Opening Bell Nov 25th on the Nasdaq Stock Market 2Inovio Pharmaceuticals to Ring Opening Bell Nov 25th on the Nasdaq Stock Market 3Study on Efficacy and Sedation-Related Safety of Flibanserin in Premenopausal Women Released Today at Sexual Medicine Society of North America Meeting 2Study on Efficacy and Sedation-Related Safety of Flibanserin in Premenopausal Women Released Today at Sexual Medicine Society of North America Meeting 3Alarming Stats Show Holiday Drinking an Issue for Many 2
... 2011 Rxbuys.com is always working on the quality and ... new options and possibilities every time they come back. This ... every visitor the right to receive a 5% discount when ... and it is valid for two months, starting from April ...
... Thoratec Corporation (Nasdaq: THOR ), a world ... and restore failing hearts, announced today that it has given ... Senior Subordinated Convertible Notes due 2034 (CUSIP No. 885175AA7) (the ... there were 243,382 notes outstanding, which can be converted into ...
Cached Medicine Technology:Web Pharmacy Rxbuys.com Gives Its Customers a 5% Discount Coupon 2Thoratec Corporation Announces Redemption of Senior Subordinated Convertible Notes Due 2034 2Thoratec Corporation Announces Redemption of Senior Subordinated Convertible Notes Due 2034 3
(Date:11/24/2014)... November 24, 2014 Abington Health ... MD has joined The Neurology Group and has ... Sclerosis Center. , A graduate of Vinnica Medical ... at Albert Einstein Medical Center in Philadelphia and completed ... Multiple Sclerosis Center at Weill Cornell Medical College. Ternopolska ...
(Date:11/24/2014)... A new sports massage technique available ... and massage therapy provider, announced it newest massage ... newest sports massage is a fast-acting, “to-the-point” ... sports massage and ESM is that ESM has ... "reset button,” and ESM can increase flexibility, elasticity, ...
(Date:11/24/2014)... Recently, SweetDressy.com, a well-known dress supplier and ... of 2014 Evening Dresses. All these fresh items are ... marketing manager, the special offer is valid until Dec. ... Sweetdressy.com has been working well in the fashion industry ... designs. Their new dresses may be the best products ...
(Date:11/24/2014)... November 24, 2014 SWAccessControl.com has ... As a matter of fact, the company is a leading ... brand new magnetic locks are available at discounted prices, up ... new range of magnetic locks. This time, all of our ... popular at home and abroad, so I have confidence in ...
(Date:11/24/2014)... The typical American diet includes foods ... Consistently consuming a diet high in calories and carbohydrates ... fat that typically accumulate around the internal organs exposing ... head in the form of love handles, beer bellies ... decision to rid themselves of the burden of embarrassing, ...
Breaking Medicine News(10 mins):Health News:Nataliya Ternopolska Named Associate Medical Director of Abington Health’s Multiple Sclerosis Center 2Health News:Sports Massage in London by Massaggi Presents New Technique to Reset Muscles, Rapidly Eliminate Pain 2Health News:Sports Massage in London by Massaggi Presents New Technique to Reset Muscles, Rapidly Eliminate Pain 3Health News:SweetDressy.com Unveiled A New Selection Of Evening Dresses 2Health News:SWAccessControl.com Is Happy To Release New Range Of Magnetic Locks 2Health News:Ketogenic Diet is the Perfect Solution for Diet Doc Patients Who Want to Learn How to Lose Weight over the Holidays 2Health News:Ketogenic Diet is the Perfect Solution for Diet Doc Patients Who Want to Learn How to Lose Weight over the Holidays 3Health News:Ketogenic Diet is the Perfect Solution for Diet Doc Patients Who Want to Learn How to Lose Weight over the Holidays 4
... of the Department of Pediatrics at the University of ... Rady Children,s Hospital-San Diego has received a $10 million ... and Blood Institute. A world renowned physician-scientist in ... of investigators from UC San Diego and the Sanford-Burnham ...
... Reporter , THURSDAY, Sept. 23 (HealthDay News) -- Distracted driving ... the space of three years, according to new U.S. government ... deaths in car accidents from 2001 to 2007, the researchers ... driving rose 28 percent in just three years, from 4,572 ...
... School of Medicine have found that the costs of care ... five times higher than for patients who remained with hospice. ... use emergency department care and be hospitalized. The results ... of Clinical Oncology. Led by Melissa D.A. Carlson, PhD, ...
... the opposing team,s offensive drive to the end zone, ... events to initiate, or block, different actions or functions. ... Center recently discovered a potential molecular playbook for blocking ... a well-known precursor of heart failure. Researchers uncovered a ...
... Center and GLG Pharma, LLC announced today that they ... Pharma, LLC has acquired the exclusive worldwide rights to ... inhibitors. Researchers at Moffitt discovered several classes of ... anti-cancer drugs. "Persistently activated STAT3 is a ...
... on women,s health over the last two decades has lessened ... to cardiovascular disease, breast cancer, and cervical cancer, says a ... has yielded less but still significant progress in reducing the ... committee that wrote the report. However, ...
Cached Medicine News:Health News:Texting Taking a Deadly Toll on Roads 2Health News:Texting Taking a Deadly Toll on Roads 3Health News:Patients with cancer who stop hospice care boost health-care costs 2Health News:Molecular 'playbook' for halting heart failure risk factor uncovered 2Health News:Increased attention to women's health research has yielded gains on some important conditions, but progress lags on others 2Health News:Increased attention to women's health research has yielded gains on some important conditions, but progress lags on others 3
US Autoflow Single Chamber Stackable Water-Jacketed CO2/O2 Inc....
...
Listeria Enrichment Broth...
1.7% Tryptone, 0.3% Soytone, 0.5% Sodium Chloride, 0.25% Dextrose, 0.25% Potassium Phosphate....
Medicine Products: