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Kinex Announces First Patient Dosed in Phase Ib Study of Oraxol, an Orally Dosed Paclitaxel
Date:10/28/2013

developed by Kinex and Hanmi through the Orascovery program.  Orascovery is based on an important platform technology developed by Hanmi Pharmaceuticals using compound HM30181A, a potent and selective P-glycoprotein (PGP) pump inhibitor.  Suppression of the PGP pump allows certain clinically important compounds (such as paclitaxel, irinotecan, and others), which would normally be effluxed back into the gastrointestinal tract and excreted, to enter the bloodstream and become bioavailable through oral administration.  Importantly, HM30181A is a very potent PGP inhibitor that is not systemically absorbed.

 


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SOURCE Kinex Pharmaceuticals
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Related medicine technology :

1. Hanmi Pharmaceuticals to Assign the Rights to Five New Territories to Kinex as Part of the Orascovery Program Strategic Plan
2. Dr. David Hangauer, Chief Scientific Officer and Co-Founder, commits his career to Kinex Pharmaceuticals
3. Kinex Receives Research Support from the Hong Kong Innovation and Technology Commission (ITC)
4. Kinex Announces that the US FDA Allows their IND for Oraxol, an Oral Form of Paclitaxel that is in Phase II Clinical Trials in Korea, to Begin Clinical Trials in the US
5. Kinex Pharmaceuticals Will Take the Lead in the Orascovery Program Development in China
6. Kinex Announces that the US FDA Allows their IND to Begin KX02 Clinical Trials
7. Kinex Pharmaceuticals and Zenith Technology Corporation announce the execution of a collaborative licensing agreement
8. Kinex Pharmaceuticals Chief Scientific Officer, Dr. David Hangauer, named the American Cancer Societys 2013 Honoree for its Cuisine for a Cure event
9. Hanmi and Kinex Announced Korean FDA Allowance of the KX01 IND Application
10. Kinex Pharmaceuticals Appoints Mr. Patrick Gallagher Vice President of Business Development and Investor Relations
11. Kinex Pharmaceuticals Receives Substantial Strategic Investment
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