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Kinex Announces First Patient Dosed in Phase Ib Study of Oraxol, an Orally Dosed Paclitaxel
Date:10/28/2013

igned to confirm that the Korean data is compatible with Oraxol's mechanism of action in non-Asians and to assess additional dosing regimens.  As paclitaxel's MOA is very well characterized, we are confident that our PK modeling work will prove predictive in this study.  Kinex is pleased to be working with Dr. Ma and Roswell Park as well as the University of Colorado on this trial and we will name an additional site in the near future. We continue to do clinical and pre-clinical work on additional compounds in the Orascovery pipeline."

Dr. Gwan Sun Lee, Chief Executive Officer of Hanmi Pharmaceutical commented, "The Kinex team has delivered another major milestone in our global development strategy.  Hanmi has long wanted Oraxol and the Orascovery platform to be global initiatives as we believe they will improve patient outcomes and provide additional options to healthcare systems. Kinex's efforts and capabilities will help make this goal a reality."  

"Patients need better chemotherapeutic options.  Taxanes are efficacious, but they come with significant side effects.  It is widely recognized that greater tolerability could lead to better patient outcomes," said Dr. Rudolf Kwan, Chief Medical Officer of Kinex.  "The dose escalation in the US Oraxol trial will help us further quantify Oraxol's benefits versus standard of care and will provide Kinex and Hanmi an excellent roadmap for disease directed studies as we progress.  Hanmi's Phase II trials continue in Korea and the addition of an US trial drives our global growth strategy forward in a significant manner.  We continue to leverage our team's combined infrastructure and development capabilities on a global basis.  We believe this approach will produce meaningful data in the most time efficient manner."

About Oraxol:

Oraxol is one of many compounds that could be
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SOURCE Kinex Pharmaceuticals
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Related medicine technology :

1. Hanmi Pharmaceuticals to Assign the Rights to Five New Territories to Kinex as Part of the Orascovery Program Strategic Plan
2. Dr. David Hangauer, Chief Scientific Officer and Co-Founder, commits his career to Kinex Pharmaceuticals
3. Kinex Receives Research Support from the Hong Kong Innovation and Technology Commission (ITC)
4. Kinex Announces that the US FDA Allows their IND for Oraxol, an Oral Form of Paclitaxel that is in Phase II Clinical Trials in Korea, to Begin Clinical Trials in the US
5. Kinex Pharmaceuticals Will Take the Lead in the Orascovery Program Development in China
6. Kinex Announces that the US FDA Allows their IND to Begin KX02 Clinical Trials
7. Kinex Pharmaceuticals and Zenith Technology Corporation announce the execution of a collaborative licensing agreement
8. Kinex Pharmaceuticals Chief Scientific Officer, Dr. David Hangauer, named the American Cancer Societys 2013 Honoree for its Cuisine for a Cure event
9. Hanmi and Kinex Announced Korean FDA Allowance of the KX01 IND Application
10. Kinex Pharmaceuticals Appoints Mr. Patrick Gallagher Vice President of Business Development and Investor Relations
11. Kinex Pharmaceuticals Receives Substantial Strategic Investment
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