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KineMed Presents Preclinical Data for Investigational Agent Demonstrating Neurogenesis and Confirming Improvements in Behavioral Model
Date:10/11/2007

so presented on KineMed's most advanced compound, KM-801, which is expected to enter clinical studies in 2008 for the treatment of Amyotrophic Lateral Sclerosis (ALS, or Lou Gehrig's disease). KM-801 is a small-molecule agent, which has been shown to alter microtubule dynamics in nerve cells in preclinical studies (J Biol Chem. 2007 Jun 13). KineMed researchers have discovered that patients with ALS have more rapid rates of turnover of microtubules, which are integral to the structure and functionality of the motor neurons affected by the disease. By using an agent that can slow down this rate of turnover, KineMed has shown in preclinical studies that it can restore balance to this key metabolic pathway and improve both symptoms and survival. KineMed's KM-801 program is currently in IND-enabling studies to support the initiation of clinical trials next year.

KineMed KineMarker(TM) Product Programs in Neurobiology

KineMed's programs utilize proprietary in vivo technologies to indentify drug candidates that can modulate several key biological pathways involved in the pathogenesis and treatment of psychiatric and neurodegenerative disorders. This approach can be applied in clinical, as well as preclinical, settings.

KineMed's Neuroinflammation and Neurogenesis KineMarkers(TM) are more sensitive, reproducible and high-throughput than traditional methods, such as histological staining, and are safer than traditional radioisotope labeling methods. Areas of neurobiology where KineMed has active discovery programs include mood disorders, ALS, multiple sclerosis, Alzheimer's disease, Parkinson's disease, and diabetic neuropathy, as well as disorders of learning and memory.

About KineMed

KineMed, Inc. ("KineMed" or the "Company") is a drug discovery and development company employing its proprietary translational medicine technology (AquaTag(TM) and KineMarker(TM)) to both identify active drug candidates preclinically and confirm their therapeutic
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