Navigation Links
KineMed Presents Preclinical Data for Investigational Agent Demonstrating Neurogenesis and Confirming Improvements in Behavioral Model
Date:10/11/2007

EMERYVILLE, Calif., Oct. 11 /PRNewswire/ -- KineMed Inc., a pathway-based drug discovery and development company, announced today presentation of data demonstrating the ability of an investigational agent to regenerate nerve cells in the hippocampus, a part of the brain involved with cognition and mood. The agent, part of a partnered relationship in indications discovery, also improved performance in a behavioral test in a preclinical model. The findings were disclosed in a presentation titled, "Indications Discovery Using In Vivo Pathways as Targets," at the second annual Drug Repositioning Summit hosted by Cambridge Healthtech Institute in Philadelphia.

According to presenter Scott Turner, Ph.D., Vice President, Research at KineMed, "The KineMed team set out to demonstrate regenerative capacity in the hippocampus because all known anti-depressants stimulate hippocampal neurogenesis, and an increase in hippocampal neurogenesis correlates with improved learning and memory. Based on the reported findings, we believe we have identified a compound that could indeed have application in treating cognitive impairment, an area of substantial unmet clinical need."

David Fineman, President and CEO of KineMed, stated, "The current findings demonstrate the power of KineMed's technology, which measures the flow of molecules through intact metabolic pathways. Using this technology, KineMed is able to take a shelved compound, or an entire drug class, and put it back into the clinic, thereby derisking the class of compounds. This is unique from other efforts because our testing takes place in the intact human and animal. As described in the research presentation, we are able to demonstrate a compound's ability to increase hippocampal neurogenesis, providing a rationale for the compound's behavioral outcome."

Mr. Fineman added, "We are proud of the achievements of our team and look forward to further progress in these and other efforts."

Dr. Turner also presented on KineMed's most advanced compound, KM-801, which is expected to enter clinical studies in 2008 for the treatment of Amyotrophic Lateral Sclerosis (ALS, or Lou Gehrig's disease). KM-801 is a small-molecule agent, which has been shown to alter microtubule dynamics in nerve cells in preclinical studies (J Biol Chem. 2007 Jun 13). KineMed researchers have discovered that patients with ALS have more rapid rates of turnover of microtubules, which are integral to the structure and functionality of the motor neurons affected by the disease. By using an agent that can slow down this rate of turnover, KineMed has shown in preclinical studies that it can restore balance to this key metabolic pathway and improve both symptoms and survival. KineMed's KM-801 program is currently in IND-enabling studies to support the initiation of clinical trials next year.

KineMed KineMarker(TM) Product Programs in Neurobiology

KineMed's programs utilize proprietary in vivo technologies to indentify drug candidates that can modulate several key biological pathways involved in the pathogenesis and treatment of psychiatric and neurodegenerative disorders. This approach can be applied in clinical, as well as preclinical, settings.

KineMed's Neuroinflammation and Neurogenesis KineMarkers(TM) are more sensitive, reproducible and high-throughput than traditional methods, such as histological staining, and are safer than traditional radioisotope labeling methods. Areas of neurobiology where KineMed has active discovery programs include mood disorders, ALS, multiple sclerosis, Alzheimer's disease, Parkinson's disease, and diabetic neuropathy, as well as disorders of learning and memory.

About KineMed

KineMed, Inc. ("KineMed" or the "Company") is a drug discovery and development company employing its proprietary translational medicine technology (AquaTag(TM) and KineMarker(TM)) to both identify active drug candidates preclinically and confirm their therapeutic activity and dose response in first-in-man studies. KineMed's technology expedites the drug development process and provides real-time insight into conditions including metabolic disorders, cancer, and diseases of inflammation and neurodegeneration.

KineMed is working to develop drugs both on its own and with pharmaceutical collaborators in therapeutic focus areas where it can demonstrate functional modulation of specific biological pathways that mediate disease. The Company has multiple development programs with more than a dozen major pharmaceutical companies, including Bayer, Merck, Merck KGaA, Organon and Roche.

For further information about KineMed, please visit: http://www.kinemed.com/


'/>"/>
SOURCE KineMed Inc.
Copyright©2007 PR Newswire.
All rights reserved

Related medicine technology :

1. KineMed Presents Data Measuring Changes in Reverse Cholesterol Transport for the First Time
2. Inspiration Biopharmaceuticals Presents Data From Hemophilia Program at International Society On Thrombosis and Haemostasis (ISTH) Annual Meeting
3. European Society for Medical Oncology (ESMO) Presents Data from the Clinical Trial of MediGenes Cancer-Killing Virus in Press Conference
4. Cytogen Presents Phase 1 Data Showing Promising Antitumor Activity and Safety Profile of Quadramet at International Myeloma Workshop
5. SemBioSys Presents Positive Insulin Data at the American Diabetes Association Conference
6. Tranzyme Pharma Presents Initial Phase IIa Data for its Novel Ghrelin Agonist, TZP-101, in Patients with Diabetic Gastroparesis
7. Novagali Pharma Presents at AACO the Results of its Pivotal Phase III Clinical Trial of Vekacia in Children Suffering From Vernal Keratoconjunctivitis
8. BioLife Solutions Presents Data on CryoStor at International Society for Cellular Therapy Annual Meeting
9. Genaera Presents Preclinical Data on Trodusquemine (MSI-1436) for the Treatment of Obesity at the American Diabetes Association 67th Scientific Session
10. Elixir Pharmaceuticals Presents Preclinical Data Highlighting Its Ghrelin Antagonist Program at the American Diabetes Associations Annual Meeting
11. DiObex Presents Phase 2a Data of DIO-902 Demonstrating Trends of Improved Glycemic Control and Significant Reductions of LDL-Cholesterol and C-Reactive Protein
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/8/2017)... Aug. 8, 2017   ... diluted (GAAP) loss per share from continuing operations ... revenues increased 16 percent to $110 million ... 27 percent to $161 million ... from continuing operations increased 8 percent to $0.93 ...
(Date:8/7/2017)... , Aug. 7, 2017  Endo International plc ... reached agreements to resolve virtually all known U.S. mesh ... discussions to resolve the known remaining U.S. claims at ... payments beginning in the fourth quarter of 2017 and ... of its second quarter 2017 results, the Company intends ...
(Date:8/2/2017)... , Aug. 2, 2017   Marshall County Hospital in Benton, ... proactively reduce the risk of hospital-acquired infections (HAIs). The new addition, Tru-D SmartUVC , ... energy to kill deadly pathogens such as C. diff , MRSA, MERS, Ebola and ... Tru-D SmartUVC ... Tru-D in action in a patient room ...
Breaking Medicine Technology:
(Date:8/18/2017)... (PRWEB) , ... August 18, 2017 , ... ... and financial planning assistance that serves communities throughout southern Florida, is working to ... provide scholarship assets to children from low income families. , The Take Stock ...
(Date:8/18/2017)... ... ... The Golseth Agency, a Texas based insurance management and financial planning assistance provider ... organized to provide support to Christina Upchurch and her two children after the loss ... returned from out of town to find her husband passed away and their home ...
(Date:8/18/2017)... ... 18, 2017 , ... Yisrayl Hawkins, Pastor and Overseer at The House of Yahweh in Abilene, ... on false teachings pertaining to the mother of the Savior whom the world calls “Mother ... different picture of the role of this historical woman. , “The world bows, kisses ...
(Date:8/18/2017)... Vermont (PRWEB) , ... August 18, 2017 , ... ... phone numbers and call tracking and monitoring solutions, announced today the launch of ... site include a modern navigation and aesthetic, fully responsive design, and an enhanced ...
(Date:8/18/2017)... ... August 18, 2017 , ... “Three Narrow Roads”: a vivid and provocative ... published author, Rev. Dr. Burnett King Sr., is currently the pastor-teacher-visionary at Simply the ... Faith Track Club, Inc., a track-and-field program geared towards youth. , King shares, “When ...
Breaking Medicine News(10 mins):