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KineMed Presents Preclinical Data for Investigational Agent Demonstrating Neurogenesis and Confirming Improvements in Behavioral Model
Date:10/11/2007

EMERYVILLE, Calif., Oct. 11 /PRNewswire/ -- KineMed Inc., a pathway-based drug discovery and development company, announced today presentation of data demonstrating the ability of an investigational agent to regenerate nerve cells in the hippocampus, a part of the brain involved with cognition and mood. The agent, part of a partnered relationship in indications discovery, also improved performance in a behavioral test in a preclinical model. The findings were disclosed in a presentation titled, "Indications Discovery Using In Vivo Pathways as Targets," at the second annual Drug Repositioning Summit hosted by Cambridge Healthtech Institute in Philadelphia.

According to presenter Scott Turner, Ph.D., Vice President, Research at KineMed, "The KineMed team set out to demonstrate regenerative capacity in the hippocampus because all known anti-depressants stimulate hippocampal neurogenesis, and an increase in hippocampal neurogenesis correlates with improved learning and memory. Based on the reported findings, we believe we have identified a compound that could indeed have application in treating cognitive impairment, an area of substantial unmet clinical need."

David Fineman, President and CEO of KineMed, stated, "The current findings demonstrate the power of KineMed's technology, which measures the flow of molecules through intact metabolic pathways. Using this technology, KineMed is able to take a shelved compound, or an entire drug class, and put it back into the clinic, thereby derisking the class of compounds. This is unique from other efforts because our testing takes place in the intact human and animal. As described in the research presentation, we are able to demonstrate a compound's ability to increase hippocampal neurogenesis, providing a rationale for the compound's behavioral outcome."

Mr. Fineman added, "We are proud of the achievements of our team and look forward to further progress in these and other efforts."

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SOURCE KineMed Inc.
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