Navigation Links
Kill the Germs, Spare the Ears: Study Shows How to Create Effective Antibiotics That Don't Damage Hearing
Date:6/11/2012

ANN ARBOR, Mich., June 11, 2012 /PRNewswire-USNewswire/ -- The world needs new antibiotics to overcome the ever-increasing resistance of disease-causing bacteria – but it doesn't need the side effect that comes with some of the most powerful ones now available: hearing loss. Today, researchers report they have developed a new approach to designing antibiotics that kill even "superbugs" but spare the delicate sensory cells of the inner ear.

Surprisingly, they have found that apramycin, an antibiotic already used in veterinary medicine, fits this bill -- setting the stage for testing in humans.

In a paper published online in the Proceedings of the National Academy of Sciences, a team from Switzerland, England and the University of Michigan show apramycin's high efficacy against bacteria, and low potential for causing hearing loss, through a broad range of tests in animals. That testing platform is now being used to evaluate other potential antibiotics that could tackle infections such as multidrug-resistant tuberculosis.

The research aims to overcome a serious limitation of aminoglycoside antibiotics, a class of drugs which includes the widely used kanamycin, gentamicin and amikacin.

While great at stopping bacterial infections, these drugs also cause permanent partial hearing loss in 20 percent of people who take them for a short course, and up to 100 percent of people who take them over months or years, for example to treat tuberculosis or lung infections in cystic fibrosis.

U-M researcher Jochen Schacht, Ph.D., a professor of biological chemistry and otolaryngology and director of the Kresge Hearing Research Institute at the U-M Medical School, has spent decades studying why these drugs cause this "ototoxicity" – a side effect that makes doctors hesitant to prescribe them. Hearing damage has also caused patients to discontinue treatment before their antibiotic prescription is over, potentially allowing drug
'/>"/>

SOURCE University of Michigan Health System
Copyright©2012 PR Newswire.
All rights reserved

Page: 1 2 3 4

Related medicine technology :

1. Surgical Equipment Market (Surgical Sutures, Surgical Hand Instruments and Electrosurgical Devices) Estimated to Reach USD 7.5 Billion Globally in 2017: Transparency Market Research
2. Catheters (Cardiovascular, Specialty, Urological, Neurovascular, and Intravenous) Market Will Reach USD 33.3 Billion Globally in 2017: Transparency Market Research
3. Halozymes Ultrafast Insulin Formulations Improved Postprandial Glycemic Control in Patients Living with Type 1 Diabetes: Phase 2 Study Results Presented at ADA 2012
4. New Medical Device Study Offers Key Marketing Budget and Staffing Metrics to Promote Effective Use of Resources
5. Lilly and Incytes Oral JAK1 and JAK2 Inhibitor, Baricitinib, Showed Positive Results in Phase IIb Study in Patients with Active Rheumatoid Arthritis
6. Brain Research Foundation Announces Grant To Study Concussive Events Among Grade School Children
7. Body Monitors Deliver Better Weight Loss Results at Half the Cost: Study to Be Presented at ACSM Meeting
8. Oncos Therapeutics Initiates Phase I Clinical Study of CGTG-102, an Oncolytic Adenovirus for the Treatment of Solid Tumor Cancers
9. FREEDOM Study Data: Patients Experience Sustained Quality of Life Benefits with More Frequent Home Hemodialysis with the NxStage System One
10. Halo Therapeutics Raises $1.1 Million to Expedite Phase 2 Study of HT-100
11. Sorbent Therapeutics CLP1001 Improves Heart Failure Symptoms In Phase 2 Clinical Study
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/4/2015)... Unchained Labs, a refreshingly new biologic tools ... conference and launches the UNit — the first and ... Essential Protein Engineering Summit takes place in ... UNit lets drug discovery researchers look at more protein ... 7 applications, 144 sample a day throughput and 9 microliter sample ...
(Date:5/4/2015)... May 4, 2015 Intarcia Therapeutics, ... Michael Williams into the newly created role ... a senior pharmaceutical executive with world-class experience – ... and distinguished service at industry leaders such as ... a broad range of therapeutic areas, including: cardiovascular, ...
(Date:5/4/2015)... N.J. , May 4, 2015 ... immunotherapy company commercializing its CytoSorb® extracorporeal cytokine adsorber ... multiple countries worldwide, will report Q1 2015 financial ... 11, 2015.  CytoSorbents, management will ... that will recount both operational and financial progress ...
Breaking Medicine Technology:Unchained Labs Lets the UNit Loose 2Intarcia Names Top Commercial Expert Michael Williams As COO; Will Chair Commercial Committee And Lead ITCA 650 Launch In U.S. 2Intarcia Names Top Commercial Expert Michael Williams As COO; Will Chair Commercial Committee And Lead ITCA 650 Launch In U.S. 3Intarcia Names Top Commercial Expert Michael Williams As COO; Will Chair Commercial Committee And Lead ITCA 650 Launch In U.S. 4CytoSorbents to Report Q1 2015 Operating and Financial Results 2CytoSorbents to Report Q1 2015 Operating and Financial Results 3
... Inhibitex, Inc. (Nasdaq: INHX ) today announced that ... its common stock, at a purchase price of $4.10 per ... proceeds to Inhibitex from the sale of the shares, after ... to be approximately $44 million.  Inhibitex has granted the underwriters ...
... Robinson, Ph.D., Chief Scientific Officer at GeoVax Labs, Inc. (OTCQB/OTCBB: ... Company,s therapeutic and preventative HIV vaccines at the 2011 World ... in Washington DC on Thursday, April 14.  Dr. Robinson,s invited ... cover the topic of recombinant viruses as vaccines. The talk ...
Cached Medicine Technology:Inhibitex Prices $47 Million Public Offering 2Inhibitex Prices $47 Million Public Offering 3GeoVax Labs HIV/AIDS Vaccine Development Leadership to be Highlighted During 2011 World Vaccine Congress 2GeoVax Labs HIV/AIDS Vaccine Development Leadership to be Highlighted During 2011 World Vaccine Congress 3
(Date:5/4/2015)... Peacock Alley knows we all ... “My mother was the most beautiful woman I ever saw.” ... feminine prints and textures to remind her just ... the Eloise Robe to get you there. The beautiful Monet-inspired ... and tapered waist. It is available in small/medium or large/extra ...
(Date:5/4/2015)... 04, 2015 Today, Cireson reveals the ... Cireson Platform to strengthen core service & asset ... choice to consume Microsoft System Center and Cireson via ... , Company transitioning from a direct sales ... Continuous innovation with expanding new solutions for password reset ...
(Date:5/3/2015)... May 03, 2015 AvePoint, ... across platforms and devices, today announced it is ... Privacy Professionals (IAPP) Asia Privacy Forum, taking place ... Throughout the event, AvePoint will showcase its compliance, ... cloud platforms. , Visit AvePoint for New Solutions ...
(Date:5/3/2015)... Lake Orion, Clarkston, Metamora, Michigan (PRWEB) May 03, 2015 ... the 2,000 ‘Like’ mark on their Facebook page. ... educate the patients on the many services the Practice ... well as current events. , Women’s Excellence has a ... Twitter, Google +, Pinterest, Instagram and You Tube. ...
(Date:5/3/2015)... (PRWEB) May 03, 2015 Leading international ... announced it will be awarding the 2015 Harris Wofford ... and Selemawit Ghebrendrias, are the deserving recipients of the ... global service, Harris Llewellyn Wofford. The two recipients were ... passion for global health. , CFHI is one ...
Breaking Medicine News(10 mins):Health News:Feminine Classics for Mother's Day Gifts from Peacock Alley 2Health News:Cireson Unveils New Microsoft Cloud & System Center Strategy 2Health News:Cireson Unveils New Microsoft Cloud & System Center Strategy 3Health News:Cireson Unveils New Microsoft Cloud & System Center Strategy 4Health News:AvePoint Showcases Compliance and Data Privacy Solutions as Platinum Sponsor of IAPP Asia Privacy Forum 2015 2Health News:AvePoint Showcases Compliance and Data Privacy Solutions as Platinum Sponsor of IAPP Asia Privacy Forum 2015 3Health News:AvePoint Showcases Compliance and Data Privacy Solutions as Platinum Sponsor of IAPP Asia Privacy Forum 2015 4Health News:SF-based Global Health Non-Profit Awards Harris Wofford Global Service Fellowship 2Health News:SF-based Global Health Non-Profit Awards Harris Wofford Global Service Fellowship 3
... Nov. 19 Smart Balance, Inc. (Nasdaq: SMBL ) ... to drive growth and performance at the Citi Investment Research ... strategy to build market share in the company,s core spreads ... of food and beverages to support healthy living under the ...
... JACKSONVILLE, Fla., Nov. 19 Improving the quality of ... will be addressed by Dr. Krysti DeZonia, co-founder of ... of the International Association for Life Quality (IALQ), at ... Fl. , The WCD Expo is dedicated ...
... Hopkins and their colleagues have developed sugar-coated polymer strands ... allergy and asthma attacks. Their advance is a significant ... conditions in a new way. For more than ... M.D., director of the Division of Allergy and Clinical ...
... Heart disease, stroke more likely for organ recipients with ... (HealthDay News) -- Kidney transplant patients with sleep apnea ... disease and stroke, Hungarian researchers say. , The study ... had moderate to severe sleep apnea, a rate similar ...
... analysis finds some areas with 1 in 10 adults ... While rates of obesity are climbing across America, they ... Southeast, the U.S. Centers for Disease Control and Prevention ... diabetes "are basically the two conditions of greatest concern ...
... Lisa Maas, executive director of Californians Allied for ... to an Associated Press/Stanford University poll released today which ... personal injury lawyers to sue health care providers. ... community clinics, local governments, dentists and other groups supporting ...
Cached Medicine News:Health News:Smart Balance, Inc. CEO Presents at Citigroup Small and Midcap Conference 2Health News:Smart Balance, Inc. CEO Presents at Citigroup Small and Midcap Conference 3Health News:Smart Balance, Inc. CEO Presents at Citigroup Small and Midcap Conference 4Health News:Dr. Krysti DeZonia to Speak at World Congress on Disabilities 2Health News:Sweet -- sugared polymer a new weapon against allergies and asthma 2Health News:Sweet -- sugared polymer a new weapon against allergies and asthma 3Health News:Kidney Transplant, Sleep Disorder May Add Up to Trouble 2Health News:Appalachia, Southeast Hit Hardest by Obesity and Diabetes 2Health News:Appalachia, Southeast Hit Hardest by Obesity and Diabetes 3Health News:National Poll Confirms Americans Support Curbs on Malpractice Lawsuits 2
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
Medicine Products: