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Kiadis Pharma to Receive GMP Manufacturing License and GMP Certificate
Date:7/22/2013

atients in need. ATIR™ thus has the potential to address this unmet need and to make stem cell transplantations available for all patients worldwide.

Those T-cells in a haploidentical graft which would cause Graft-versus-Host-Disease (GvHD) are selectively eliminated using proprietary technology to produce ATIR™. ATIR™ is administered as an adjunctive treatment after a haploidentical stem cell transplantation facilitating early immune reconstitution without causing life-threatening (acute) GvHD.

In a Phase I/II study with ATIR™, safety and proof of concept were confirmed in terms of absence of grade III/IV GvHD, reduced rates of infection, reduced Transplant Related Mortality and high Overall Survival.

ATIR™ is currently in Phase II clinical development and has been granted Orphan Drug Designation both in the EU and the USA. In these regions, 20,000 to 25,000 patients a year are unable to find a suitable standard of care matched donor. Together, both regions represent a combined primary market potential of more than EUR 1 billion per year.

About Kiadis Pharma

Kiadis Pharma B.V. is a private, clinical stage biopharmaceutical company developing innovative and potentially life-saving therapies for patients with late stage blood cancers and related disorders who are in need of a transplant, an area of significant unmet medical need.

Kiadis Pharma's lead product is ATIR™, a cell based product currently in Phase II development, which is designed to enable stem cell transplantations from partially mismatched (haploidentical) family donors. Kiadis Pharma is collaborating with internationally renowned centers in Europe and North America for the successful development and manufacturing of ATIR™.

Kiadis Pharma is supported by a strong group of leading international investors including LSP, Alta Partners, DFJ Es
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SOURCE Kiadis Pharma
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