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Kiadis Pharma Announces Collaboration With the Julius Maximilians University of Wurzburg, Germany
Date:5/29/2008

Dr. Mielke Continues his Collaboration With Kiadis Pharma on ATIR(TM)

AMSTERDAM, May 29 /PRNewswire/ -- Biopharmaceutical company Kiadis Pharma announces today the clinical development collaboration for its lead product ATIR(TM) with Dr. Stephan Mielke and Professor Dr. Hermann Einsele from the Allogeneic Stem Cell Transplant Center, Division of Hematology and Oncology, Department of Internal Medicine II at the Julius-Maximilians University of Wurzburg, Germany. Principal investigator of this collaboration will be Dr. Mielke.

Previously, Dr. Mielke initiated the ongoing phase II clinical study for ATIR(TM) as principal investigator at the Hematology Branch of the National Heart, Lung and Blood Institute (NHLBI) at the National Institutes of Health (NIH) in Bethesda, Maryland, USA, together with Dr. John Barrett, Chief of the Allogeneic Stem Cell Transplant Section at the Hematology Branch. The investigators selected ATIR(TM) for a clinical study after a pre-clinical research program and have published the pre-clinical data showing promising results with Kiadis Pharma's ATIR(TM) in eliminating alloreactive T-cells from donor grafts (Mielke et al. Blood 2008). Dr. Mielke and colleagues additionally developed a reliable large scale manufacturing protocol with a "GMP-like" semi-closed system for cell processing with ATIR(TM).

"We are extremely pleased with this collaboration which shows the interest of leading transplantation physicians to continue working with our lead product ATIR(TM) as well as to participate in setting up our next clinical study in Europe," says Dr. Manja Bouman, CEO of Kiadis Pharma.

According to Dr. Mielke selective allodepletion with ATIR(TM) carries significant potential for improving the outcome of mismatched (haploidentical ) transplants by allowing early immune reconstitution with less severe or no acute Graft versus Host Disease (GvHD). Therefore, Dr. Mielke and his team and Kiadis Pharma are planning to ini
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