Navigation Links
Key Protein May Lead to Faster Acting Anti-Depression Drugs
Date:3/23/2009

NEW YORK, March 23 /PRNewswire-USNewswire/ -- Research conducted by Nobel laureate Paul Greengard, Medical Director of The Michael Stern Parkinson's Research Center at The Rockefeller University, Dr. Jennifer L. Warner-Schmidt in New York and colleagues in Sweden, demonstrated in the Journal of Neuroscience that the brain protein called p11 could lead pharmaceutical companies to develop anti-depression drugs that begin working within hours or days rather than the weeks or even months required by current drugs.

This study, Role of p11 in Cellular and Behavior Effects of 5-HT4 Receptor Stimulation, solidifies the protein p11 as a key determinant of vulnerability to depression. This new research shows that p11 activates a serotonin receptor in the brain known for producing rapid antidepressant response.

"There is pressing clinical need for faster-acting antidepressants," says Greengard. "An understanding of the cellular mechanisms underlying the therapeutic actions of these drugs may lead to better treatments with fewer side effects." In fact, each year over 17 million American adults experience at least one episode of clinical depression. Depression experts claim that many people with a depressive illness never seek treatment. Perhaps if there were antidepressants available that could start working in hours or days rather than weeks or months, more people would seek treatment.

Previous research by Greengard, who was awarded the 2000 Nobel Prize in Medicine or Physiology, helped establish p11 as an important protein that regulates signaling in the brain by the neurotransmitter serotonin, which has long been linked to mood. Michael Stern Parkinson's Research Center scientists begun studying p11 because the serotonin system which is central to depression is connected to dopamine in Parkinson's disease.

The Michael Stern Parkinson's Research Foundation visi
'/>"/>

SOURCE The Michael Stern Parkinson's Research Foundation
Copyright©2009 PR Newswire.
All rights reserved

Page: 1 2

Related medicine technology :

1. Bone Biologics Announces Significant Milestone for Spinal Fusion Surgery Using Recombinant Protein and Demineralized Bone Matrix
2. Aiming at Multiple Alzheimers Proteins May be Key to Success
3. Protein Shown to Play a Key Role in Normal Development of Nervous System
4. St. Jude Study Gives New Insights Into How Cells Accessorize Their Proteins
5. The First Direct Structural Evidence of SV2A has Been Revealed Thanks to Protein Tomography(TM), and Published in BBRC
6. Protein Key to Control Growth of Blood Cells
7. Phase II Data on Lillys Antibody Show It Affects Amyloid Beta, a Protein Believed To Be Associated with Alzheimers Disease
8. Pressure Cycling Technology (PCT) Results in a Higher Yield of Proteins and in the Extraction of Proteins Not Previously Identified in Cancer, Stroke, and IVF Studies
9. Ion Mobility Diagnostic Test from Quest Diagnostics is First to Provide Direct Physical Measurement of Lipoprotein Particles, Cardiovascular Disease Indicators, Study Finds
10. CellCyte Genetics Corporation Selects Washington University School of Medicine to Perform Study on CellCytes Glycoprotein Products in Heart Attack Disease Model
11. Protein Tomography(TM) Reveals Molecular Mode of Action of Humax-EGFr Published in PNAS
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/29/2014)... Mass., July 29, 2014 Cynosure, Inc. ... markets laser- and light-based aesthetic treatment systems for high-volume ... ended June 30, 2014. Second-quarter 2014 financial results incorporate ... on June 24, 2013. Second-Quarter ... increased 45% to $72.6 million , Non-GAAP net ...
(Date:7/29/2014)... July 29, 2014   ... will present data from a Phase I clinical ... slow or stop Parkinson,s disease progression. The Michael J. ... grant and will discuss the impact of the results ... When:   Thursday, July 31, 2014     ...
(Date:7/29/2014)... Calif. , July 29, 2014  Drug ... amplified with rising incidence rates and the intense ... a preventative vaccine. Change is underway as the ... regimens towards highly effective, easily-tolerated, interferon-free oral therapies. ... Gilead,s mega blockbuster Sovaldi is ...
Breaking Medicine Technology:Cynosure Reports Second-Quarter 2014 Financial Results 2Cynosure Reports Second-Quarter 2014 Financial Results 3Cynosure Reports Second-Quarter 2014 Financial Results 4Cynosure Reports Second-Quarter 2014 Financial Results 5Cynosure Reports Second-Quarter 2014 Financial Results 6Cynosure Reports Second-Quarter 2014 Financial Results 7Cynosure Reports Second-Quarter 2014 Financial Results 8Cynosure Reports Second-Quarter 2014 Financial Results 9Cynosure Reports Second-Quarter 2014 Financial Results 10Cynosure Reports Second-Quarter 2014 Financial Results 11Cynosure Reports Second-Quarter 2014 Financial Results 12Reminder/Media Advisory/AFFiRiS AG Presents Early Clinical Data on a First-of-its-Kind Parkinson's Disease Vaccine 2A Treatment Revolution is Underway: All-Oral Therapies Transform Global Hepatitis C Antiviral Market 2A Treatment Revolution is Underway: All-Oral Therapies Transform Global Hepatitis C Antiviral Market 3A Treatment Revolution is Underway: All-Oral Therapies Transform Global Hepatitis C Antiviral Market 4
... September 24 , - Novel Treatment ... and Reduction in Depressive Symptoms, Positive ... today at the 8th,European Congress of Epileptology, ... a novel once daily,anti-epileptic agent, significantly reduced ...
... Oral Insulin Capsule, ... on Type 1 Diabetics, JERUSALEM, Israel, September ... delivery systems, announced today that it has commenced Phase 2A,studies of ORMD ... Medical Center in Jerusalem, Israel., Oramed,s Phase 2A trial is focused ...
Cached Medicine Technology:New Data Show Efficacy of Zebinix(TM) in the Treatment of Epilepsy 2New Data Show Efficacy of Zebinix(TM) in the Treatment of Epilepsy 3New Data Show Efficacy of Zebinix(TM) in the Treatment of Epilepsy 4New Data Show Efficacy of Zebinix(TM) in the Treatment of Epilepsy 5New Data Show Efficacy of Zebinix(TM) in the Treatment of Epilepsy 6Oramed Pharmaceuticals Commences Phase 2A Trials of its Oral Insulin Capsule on Type 1 Diabetics 2
(Date:7/29/2014)... Society of America (GSA) the nation,s largest ... has chosen Barbara J. Bowers, PhD, RN, FAAN, of ... the Task Force on Minority Issues in Gerontology Outstanding ... to an individual who has exemplified outstanding commitment and ... aging. , The award presentation will take place at ...
(Date:7/29/2014)... likely to drink alcohol brands that advertise on television ... new and compelling evidence of a strong association between ... This is the conclusion of a new study from ... the Johns Hopkins Bloomberg School of Public Health and ... whether exposure to brand-specific alcohol advertising on 20 television ...
(Date:7/29/2014)... the nation,s largest interdisciplinary organization devoted to ... Lckenhoff, PhD, of Cornell University as the 2014 recipient ... Award in Behavioral and Social Gerontology. , This distinguished ... behavioral and social gerontology. Individuals who have received their ... award is given by GSA in conjunction with the ...
(Date:7/29/2014)... Nation Homelands, NY (PRWEB) July 29, 2014 ... Indian Nation have sent a letter to Washington NFL team ... representatives that opposition to the R-word racial slur is emanating ... date, the team and Snyder have yet to respond. ... release the full text of the letter, which was first ...
(Date:7/29/2014)... The report “Filling Equipment Market by Industry (Food, ... Weight), Process (Manual, Semi-Automatic, Automatic), Product (Solid, Semi-Solid, ... to 2019”, defines the filling equipment market and ... segments with analyses and projections of the market ... of value. It also identifies the driving and ...
Breaking Medicine News(10 mins):Health News:Bowers to receive GSA's 2014 Minority Mentorship Award 2Health News:Brand-specific television alcohol ads predict brand consumption among underage youth 2Health News:Löckenhoff earns GSA's 2014 Baltes Foundation Award 2Health News:Native American Groups Urge Washington Team Owner Dan Snyder to Stop Claiming Name Change Issue Driven by "Elites" Who Are Not People of Color 2Health News:Filling Equipment Market worth $8 Billion by 2019 - Report by MarketsandMarkets 2Health News:Filling Equipment Market worth $8 Billion by 2019 - Report by MarketsandMarkets 3Health News:Filling Equipment Market worth $8 Billion by 2019 - Report by MarketsandMarkets 4
... in UK it has been revealed that a increase in ... way we eat over the years.,The Mental Health Foundation and ... // have led to an increase in cases of depression, ... of the most important findings of the report was a ...
... Battle against Cancer, Singer, Actress and Diva Kylie Minogue has ... ,In a statement issued this week the Singer said ... // however her treatments were still ,continuing. ,It ... in the care ,of her family and friends after her ...
... Health Inc. told the National Heritage Insurance Co., the contractor ... accepted to cover its test. ,After this the ... $2.46 to $12.41 on Nasdaq. The company prepares oncotype DX ... is taking all the responsibility to cover the medical expenses ...
... applied for a financial grant amounting to approximately 110// ... for combating tuberculosis, said the Cabinet Minister. // ... Fund on AIDS, TB and Malaria, according to the ... approximately 15 and 30 million dollars would be approved ...
... scientific and research talent in frontier areas of research ... the preferred hub for knowledge-based industries. // ... to information and communication technology alone, but spans agriculture, ... space. ,India's efforts to become a superpower ...
... of the HIV drugs in the city of Vancouver in British ... 125 as a last hope to save their lives. // Though ... study is tested on a hope to find a cure and ... ,TMC 125 is Non-nucleoside reverse transcriptase inhibitor, which has found ...
Cached Medicine News:Health News:India set to become the global knowledge hub 2Health News:India set to become the global knowledge hub 3Health News:India set to become the global knowledge hub 4
... German Craftsmanship have produced ... in the world. Ocutek ... to you! Only holders ... certificate, which requires and ...
... German Craftsmanship have produced ... in the world. Ocutek ... to you! Only holders ... certificate, which requires and ...
... are constructed of a patented ... polyvinyl acetal sponge. Each device ... to both surgeon and patient, ... firm enough to gently manipulate ...
... Merocel Ophthalmic Products provide ... fiber free products for ... safe cleaning of fine ... Merocel material is highly ...
Medicine Products: