Navigation Links
Keryx Biopharmaceuticals Announces Phase 2 Data for KRX-0401 (Perifosine) in Hodgkin's Lymphoma Presented at ASH Meeting
Date:12/13/2011

NEW YORK, Dec. 13, 2011 /PRNewswire/ -- Keryx Biopharmaceuticals, Inc. (NASDAQ: KERX) (the "Company") today reported that encouraging clinical data from a Phase 2 clinical study in patients with refractory/relapsed Hodgkin's Lymphoma was presented yesterday during the Annual Meeting of the American Society of Hematology, which is currently being held in San Diego, California. In a poster presentation by Anna Guidetti, MD, Fondazione IRCCS Instituto Nazionale Tumori, Milan, Italy, preliminary response data showed that perifosine combined with sorafenib significantly increased median progression free survival (PFS) in refractory/relapsed Hodgkin's Lymphoma patients with high phosphorylation levels of Erk and Akt as compared to patients with low baseline phosphorylation levels of Erk and Akt. 

The Phase 2 Study

In abstract # 3705, entitled "Phosphorylation Levels of Extracellular-Signal Regulated Kinase (Erk) and Akt in Circulating Lymphocytes Predict Response to Targeted Therapy with Perifosine and Sorafenib in Refractory/Relapsed Hodgkin Lymphoma Patients,"  phosphorylation levels of Erk (pErk) and Akt (pAkt) were evaluated in circulating lymphocytes from patients enrolled in two consecutive Phase 2 trials evaluating the activity and safety of sorafenib as a single agent or in combination with perifosine in relapsed/refractory Hodgkin Lymphoma patients.

Four patients were treated with sorafenib alone at a dose level of 400mg BID and twenty-one patients received a 4-week treatment with perifosine alone at a dose level of 50mg BID followed by a perifosine/sorafenib combination therapy with 50mg BID and 400mg BID, respectively. Circulated lymphocytes were evaluated for their phosphorylation levels of Erk and
Akt in order to assess predictive value of the phosphokinase levels for therapy responses.

R
'/>"/>

SOURCE Keryx Biopharmaceuticals, Inc.
Copyright©2010 PR Newswire.
All rights reserved

Page: 1 2 3 4

Related medicine technology :

1. Keryx Biopharmaceuticals Announces Highlights from Zerenex™ (ferric citrate) Poster Presentations at American Society of Nephrology Kidney Week 2011 Annual Meeting
2. Keryx Biopharmaceuticals to Present at Lazard Capital Markets 8th Annual Healthcare Conference
3. Keryx Biopharmaceuticals, Inc. Announces Third Quarter 2011 Financial Results
4. Keryx Biopharmaceuticals, Inc. to Host Conference Call on Third Quarter 2011 Financial Results
5. Keryx Biopharmaceuticals Announces Upcoming Corporate Presentations
6. Keryx Biopharmaceuticals, Inc. Announces Second Quarter 2011 Financial Results
7. Keryx Biopharmaceuticals, Inc. to Host Conference Call on Second Quarter 2011 Financial Results
8. Keryx Biopharmaceuticals, Inc. Prices Common Stock Offering
9. Keryx Biopharmaceuticals Announces Commencement of Phase 3 Program of Ferric Citrate (Zerenex™) in Japan by Partner, Japan Tobacco and Torii Pharmaceutical
10. Keryx Biopharmaceuticals Announces Two Poster Presentations on KRX-0401 (Perifosine) at Upcoming American Association for Cancer Research (AACR) Annual Meeting
11. Keryx Biopharmaceuticals, Inc. Announces Fourth Quarter and Year-End 2010 Financial Results
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/25/2014)... , Oct. 24, 2014   Metanome, Inc. ... comprehensive metagenomic services and data analysis, was the genomic ... ) Phase I/II clinical trial of SER 109, ... recurrent Clostridium difficile infections (CDI). ... Seres Health,s R&D and clinical programs. Such genomic characterization ...
(Date:10/25/2014)... , October 24, 2014 ... http://www.researchandmarkets.com/research/wdq92g/global_and ) has announced the addition of ... Report 2014"  report to their offering.  ... Global and Chinese Acne Medication Industry Report ... on the current state of the global ...
(Date:10/25/2014)... 24, 2014 Best Practices designed the ... with a forum for sharing insights about the ... a mechanism for creating and sharing solutions through ... findings from the Medical Affairs Consortium survey. ... for the first roundtable of the 2014-2015 Medical ...
Breaking Medicine Technology:Metanome Selected as Metagenomics Provider for Seres Health Clinical Trial 2Global and Chinese Acne Medication Industry Report 2014 2Global and Chinese Acne Medication Industry Report 2014 3Strong Participation in Best Practices' Medical Affairs Consortium Survey 2
... Nov. 3, 2010 Telik, Inc. (Nasdaq: TELK ... $0.09 per share, for the third quarter ended September 30, ... $0.11 per share, for the comparable period in 2009. ... costs and expenses were $4.7 million, compared with $6.2 million in ...
... N.J., Nov. 3, 2010 Regado Biosciences, a privately ... active control agents, announced that Ellen McDonald, MBA, Senior ... at IMPACT 2010 held at the Pennsylvania Convention Center ... at 11:13 a.m. EST on Wednesday, November 10 in ...
Cached Medicine Technology:Telik Announces Third Quarter 2010 Financial Results 2Telik Announces Third Quarter 2010 Financial Results 3Regado Biosciences to Present at the IMPACT 2010 Conference in Philadelphia, Pennsylvania 2Regado Biosciences to Present at the IMPACT 2010 Conference in Philadelphia, Pennsylvania 3
(Date:10/25/2014)... 24, 2014 (HealthDay News) -- October,s shorter, darker days ... affective disorder, according to an expert. People ... feel overly tired, lack motivation and even have trouble ... lead to suicide, said Dr. Angelos Halaris, a professor ... Loyola University Chicago Stitch School of Medicine. "Seasonal ...
(Date:10/22/2014)... Medical Solutions , the ... to announce that our co-founder and CFO, Scott ... Staffing 100 for 2014. Anderson was also named ... people in the staffing industry,” in 2013.     , ... healthcare staffing company in the U.S., was named ...
(Date:10/22/2014)... TUESDAY, Oct. 21, 2014 (HealthDay News) -- The ... passengers arriving from Ebola-affected nations of West Africa ... screen them for infection with the virus. ... Jeh Johnson noted that 94 percent of air ... land at one of these five airports -- ...
(Date:10/22/2014)... 22, 2014 With the Affordable Care Act ... by the American Institutes for Research (AIR) finds that three ... use health insurance, but 42 percent say they are not ... before signing up for coverage. , The AIR survey found ... percent able to calculate correctly how much they owe for ...
(Date:10/22/2014)... Losing Weight Your Body’s Way , In a world ... face, it certainly can be difficult to choose the right ... favor by doing it the healthy way? Set aside the ... your body, exercise regularly, and choose foods with the most ... you need to exercise more and eat less. Despite the ...
Breaking Medicine News(10 mins):Health News:Dark Days Here for Folks With Seasonal Depression 2Health News:Medical Solutions Co-Founder/CFO Scott Anderson Named to Staffing Industry Analysts’ 2014 Staffing 100 2Health News:Medical Solutions Co-Founder/CFO Scott Anderson Named to Staffing Industry Analysts’ 2014 Staffing 100 3Health News:Passengers From Ebola-Affected Countries Must Land at Designated U.S. Airports 2Health News:Passengers From Ebola-Affected Countries Must Land at Designated U.S. Airports 3Health News:Many Americans Fail to Ask Basic Questions Before Signing Up for Health Insurance, National Survey Finds 2Health News:Many Americans Fail to Ask Basic Questions Before Signing Up for Health Insurance, National Survey Finds 3Health News:Many Americans Fail to Ask Basic Questions Before Signing Up for Health Insurance, National Survey Finds 4Health News:ReductionGuruMD Presents Ways to Improve Your Weight Loss Results 2
... new diagnostic technique capable of producing three-dimensional, in-depth ... number of women who are recalled for additional ... clinical trial being conducted at Emory University Breast ... annual meeting of the Radiological Society of North ...
... Procedures through the Belly Button: Scar-Free ... ... Nov. 28 Cleveland Clinic urologists recently,performed a series of ... repair), ileal ureter replacement, and psoas hitch uretero-,neocystostomy (for ureteral ...
... Medical Entrepreneurs is Only a Phone Call or ... care entrepreneurs,working outside the traditional health insurance payment ... computer software to make,medical care more accessible and ... the National Center for Policy Analysis (NCPA)., http://www.ncpa.org/pub/st/st305/st305.pdf ...
... Be Presented at 9:00 a.m. ... ... The Trade, Health and Environment,Impact Project, a collaboration of community organizations ... East Yard Communities for Environmental Justice, Center for,Community Action & Environmental ...
... and clinical ... development experience to Celator., PRINCETON, N.J., ... develop combination chemotherapies to,treat different types of cancer, today ... R. Appelbaum, M.D., head of the,University of Washington School ...
... that had the neurological disease, researchers say , WEDNESDAY, ... to a possible treatment for amyotrophic lateral sclerosis (ALS), ... a protein normally found in human cells into mice ... The team found that the treatment delayed symptoms and ...
Cached Medicine News:Health News:'Stereo' mammography takes breast imaging to a new dimension 2Health News:World Firsts by Cleveland Clinic Urologists 2Health News:NCPA Study: Government, Insurers Keep Medicine in Stone Age 2Health News:NCPA Study: Government, Insurers Keep Medicine in Stone Age 3Health News:Los Angeles Port Pollution, Int'l Trade & Goods Movement Conference This Weekend 2Health News:Frederick R. Appelbaum, M.D. and Ross C. Donehower, M.D. Join Scientific Advisory Board of Celator(R) Pharmaceuticals 2Health News:Cell Protein Might Help Treat ALS 2
96-Well PCR Plate Sealing Mat...
Easy to pierce, remove using foil stripper...
Inquire...
... Sealing Foil and Heat Sealing Film each provide ... safe and easy sample storage. In automated procedures ... standard pipette tips. The Heat Sealing Film is ... the plates. Heat Sealing Foil is removed by ...
Medicine Products: