Navigation Links
Keryx Biopharmaceuticals, Inc. Reports Updated Phase 1/2 Data, Including New Survival Data, on KRX-0401 (Perifosine) in the Treatment of Advanced Multiple Myeloma at the 51st Annual Meeting of the American Society of Hematology
Date:12/7/2009

r response (CR, PR or MR), was the primary endpoint, with Time to Progression (TTP), Progression-Free Survival (PFS), Overall Survival (OS) and Safety as secondary endpoints.

Seventy-three patients were evaluable for efficacy. Evaluable patients are defined as those patients who had received at least two cycles of therapy on the combination of perifosine with bortezomib. Of the 73 evaluable patients, 53 patients (73%) were previously refractory to bortezomib (defined as progression on or within 60 days of treatment to a bortezomib-based regimen), including 44 patients who were refractory to the combination of bortezomib + dexamethasone. Twenty evaluable patients (27%) were relapsed to a prior bortezomib-based regimen. Best response for all 73 evaluable patients was as follows:




   Evaluable
    Patients    CR /nCR*      PR        MR         ORR        SD**
   ---------    --------   --------   -------    -------    -------
 All Evaluable
    Patients
     (n=73)      3    4%   13   18%   14  19%    30  41%    30  41%
 -------------  ---  ---   ---  ---   --- ---    --- ---    --- ---
   Bortezomib
    Relapsed
     (n=20)      2   10%    7   35%    4  20%    13  65%     7  35%
   ----------   ---  ---   ---  ---   --- ---    --- ---    --- ---
   Bortezomib
   Refractory
     (n=53)      1    2%    6   11%   10  19%    17  32%    23  43%
   ----------   ---  ---   ---  ---   --- ---    --- ---    --- ---

*   nCR = Near Complete Response is defined as meeting the criteria
    for CR (non-detectable monoclonal protein by serum and urine),
    except with detectable monoclonal protein by immunofixation.
**  SD = Stable Disease for a minimum of 3 months.

Approximately 60% (45 / 73) of patients demonstrated progression (or SD for 4 cycles) at some point in their treatment and received 20 mg dexamethasone, four times per week, in addition to perifosine plus bortezomib. Responses occurred both with patients taking perifosine in co
'/>"/>

SOURCE Keryx Biopharmaceuticals, Inc.
Copyright©2009 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6 7

Related medicine technology :

1. Keryx Biopharmaceuticals to Present at William Blair & Company Small-Cap Growth Stock Conference
2. Keryx Biopharmaceuticals, Inc. Announces Positive Preliminary Phase 2 Data on KRX-0401 in Patients with Chemo-Insensitive Rare Sarcoma
3. Keryx Biopharmaceuticals, Inc. Announces Phase 1 and Phase 2 Data on KRX-0401 (Perifosine) in Patients with Relapsed/Refractory Multiple Myeloma at 49th Annual Meeting of American Society of Hematology
4. Keryx Biopharmaceuticals Completes SUN-MICRO Phase 3 Pivotal Trial
5. Keryx Biopharmaceuticals Announces that the SUN-MICRO Phase 3 Clinical Trial Failed to Meet its Primary Efficacy Endpoint
6. Keryx Biopharmaceuticals Announces Termination of SUN-MACRO Phase 4 Trial
7. Keryx Biopharmaceuticals, Inc. Announces Poster Presentation Highlighting Observed Clinical Activity of KRX-0401 (Perifosine) at the American Society of Clinical Oncology Meeting in Chicago, Illinois
8. Keryx Biopharmaceuticals, Inc. Announces Phase 2 Results on KRX-0401 (Perifosine) in Patients with Relapsed/Refractory Waldenstroms Macroglobulinemia at the 44th Annual Meeting of the American Society of Clinical Oncology
9. Keryx Biopharmaceuticals, Inc. Reports Phase 1/2 Data on KRX-0401 (Perifosine) at 50th Annual Meeting of American Society of Hematology
10. Keryx Biopharmaceuticals, Inc. Reports Updated Phase 1/2 Data on KRX-0401 (Perifosine) in Combination with Bortezomib (+/- Dexamethasone) at the 12th International Multiple Myeloma Meeting
11. Keryx Biopharmaceuticals Reports Single Agent Phase 2 Data of KRX-0401 (Perifosine) Further Demonstrating KRX-0401s Activity in the Treatment of Advanced Metastatic Renal Cell Cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/19/2014)... 2014  Sage Analytics ( www.sageanalytics.com ), the ... the testing of marijuana potency and moisture content, ... Profiler, the industry,s first product suite capable of ... portable unit. Designed from the ground ... cannabis industry, the Luminary™ Profiler utilizes specially purposed ...
(Date:12/19/2014)... Ky. , Dec. 18, 2014 Baptist Health ... States to receive full Atrial Fibrillation with Electrophysiology ... Care (SCPC). Atrial fibrillation is the most common ... that in some cases can lead to stroke and possible ... United States have atrial fibrillation and the numbers ...
(Date:12/19/2014)... robust development with the growth pace keeping at 20%-30% in ... the size of China separating membrane ... to 16.3%. It is projected that China ... around 20% in the upcoming years and that the figure ... An integrated membrane industrial system has taken shape in ...
Breaking Medicine Technology:Sage Analytics Develops Breakthrough System for Potency Testing of Cannabis Products 2Baptist Health Lexington First in the Nation to Receive Atrial Fibrillation with EPS Accreditation 2Baptist Health Lexington First in the Nation to Receive Atrial Fibrillation with EPS Accreditation 3Separation Membranes Market (Company, Country & Application) Research Reports for Global and Chinese Regions 2Separation Membranes Market (Company, Country & Application) Research Reports for Global and Chinese Regions 3
... 16, the U.S. Supreme Court will hear arguments in an ... v. SmithKline Beecham Corp. The specific question in the ... overtime pay. The larger issue is the deference that is ... statute. The Fair Labor Standards Act and ...
... April 10, 2012 Mylan Inc. (Nasdaq: MYL ... and live webcast on Thursday, April 26, 2012, at 10:00 ... first quarter 2012, which ended March 31, 2012. Mylan will ... opens. The dial-in number to access the call ...
Cached Medicine Technology:Supreme Court to Decide Overtime Fate for Pharmaceutical "Sales Representatives" -- JacksonWhite, Kingsley & Kingsley and Sanford Wittels & Heisler 2Supreme Court to Decide Overtime Fate for Pharmaceutical "Sales Representatives" -- JacksonWhite, Kingsley & Kingsley and Sanford Wittels & Heisler 3
(Date:12/19/2014)... Dec. 18, 2014 (HealthDay News) -- Traveling through the ... measles virus to three others within a four-hour time ... a new report shows. "The exposures in this ... rather than an international terminal, highlighting the fact that ... Jared Vega, an infectious disease specialist at the U.S. ...
(Date:12/19/2014)... HealthDay Reporter THURSDAY, Dec. 18, 2014 ... for at least 20 seconds you may be at risk ... one leg may indicate that small strokes or tiny bleeds ... strokes is high, the investigators reported online Dec. 18 in ... standing on one leg, as well as problems walking, should ...
(Date:12/17/2014)... 2014 Dr. Myo Nwe is the co-author ... of the Future” and co-founder of the Ace Medical Weight ... Nwe takes a broad look at the industry of weight ... scientific scrutiny. On film and in television shows, however, she ... the social aspects and played for basic laughs, which she ...
(Date:12/17/2014)... RI (PRWEB) December 17, 2014 ... recognize private practices that have made outstanding and ... in support and progression of private practice physical ... American Physical Therapy Association. , On behalf of ... OCS, owner and CEO of Performance accepted the ...
(Date:12/17/2014)... (PRWEB) December 17, 2014 A group of ... for Longevity, today, in reaction to a recent statement by ... of brain training and derogated the efficacy of all brain ... agreed with the parts of the center’s statement critical of ... the center had also overstated its case, in a document ...
Breaking Medicine News(10 mins):Health News:Arriving Now at Gate 42: Measles 2Health News:Arriving Now at Gate 42: Measles 3Health News:Can You Balance on One Leg? You May Have Lower Stroke Risk 2Health News:Obesity Should Not Be a Hollywood Punchline, Weight Loss Doc Says 2Health News:Performance Physical Therapy Awarded with Jayne L. Snyder Private Practice of the Year 2014 2Health News:Scientists to Stanford: Research Shows Brain Exercises Can Work 2Health News:Scientists to Stanford: Research Shows Brain Exercises Can Work 3Health News:Scientists to Stanford: Research Shows Brain Exercises Can Work 4
... WASHINGTON, Sept. 16 The Amputee Coalition of America and ... Tom Harkin and Olympia J. Snowe and Representatives Robert E. ... joint organizations, 2009 Legislative Appreciation Awards. , , ... http://www.prnewswire.com/mnr/aopa/40117/ , , (Photo: ...
... , , Prostate ... , DENVER, Sept. 16 This September, the Prostate ... take lifesaving measures. In just 10 minutes, the same amount ... screened for prostate cancer, the second leading cause of death among ...
... , , , NORWALK, ... theft protection services, today announced the availability of new features in its ... damaging types of identity theft: medical identity theft. , , ... if personal health records containing inaccurate information are used by health care ...
... WASHINGTON, Sept. 16 While research shows many American children become ... is reversing the trend by motivating them to be more physically ... To view the Multimedia News Release, go to: http://www.prnewswire.com/mnr/ccna/39748/ ... launched in 2005 by Boys & Girls Clubs of America (BGCA) ...
... , , PITTSBURGH, Sept. 16 Mylan ... privately held Indian subsidiary, Matrix Laboratories Limited, has received tentative ... the President,s Emergency Plan for AIDS Relief (PEPFAR) for its ... Fumarate Tablets, 600 mg/300 mg/300 mg. , , ...
... , , , ... business of beauty and there was nothing more beautiful at the ... donated by designers such as Giorgio Armani, Tadashi and Luca Luca. ... and even created a Limited Edition Clarisonic just for the occasion. ...
Cached Medicine News:Health News:Video: Members of Congress Receive Legislative Awards From National Amputee Organizations 2Health News:Video: Members of Congress Receive Legislative Awards From National Amputee Organizations 3Health News:Free Screenings During Prostate Cancer Awareness Week 2Health News:Free Screenings During Prostate Cancer Awareness Week 3Health News:Affinion Security Center Launches Benefits to Help Detect and Resolve Medical Identity Theft 2Health News:Affinion Security Center Launches Benefits to Help Detect and Resolve Medical Identity Theft 3Health News:Video: Teen Girls Less Active, but Triple Play Program Bucks Trend 2Health News:Video: Teen Girls Less Active, but Triple Play Program Bucks Trend 3Health News:Video: Teen Girls Less Active, but Triple Play Program Bucks Trend 4Health News:Mylan's Matrix Receives Tentative FDA Approval Under PEPFAR for Efavirenz, Lamivudine and Tenofovir Disoproxil Fumarate Tablets 2Health News:Brooke Burke Debuts Limited Edition 'Couture' Clarisonic on Ultimate Style Stage: The SGK Pink Dress Runway at New York Fashion Week 2Health News:Brooke Burke Debuts Limited Edition 'Couture' Clarisonic on Ultimate Style Stage: The SGK Pink Dress Runway at New York Fashion Week 3
Bruns (Volkmann) bone curette, with Novotex plastic handle (autoclavable in autoclave up to 143C by 3 bar), 9, oval....
15" overall length, 9" handle....
9.5" overall length, 4.5" handle....
...
Medicine Products: