Navigation Links
Keryx Biopharmaceuticals, Inc. Announces Phase 2 Results on KRX-0401 (Perifosine) in Patients with Relapsed/Refractory Waldenstroms Macroglobulinemia at the 44th Annual Meeting of the American Society of Clinical Oncology
Date:6/3/2008

60+, 24+

Minimal Response 10(28%) 36(range 9 - 68+)

ORR (PR + MR) 12(33%)

Stable Disease 22(61%)

Progression 2(5%)

PR: > 50% reduction in IgM / MR: > 25% reduction in IgM

11/36 patients remain on treatment and the median Time to Progression (TTP) has not been reached (8 cycles with a range of 2 - 17+). In summary, the investigators conclude that single agent perifosine showed encouraging activity with manageable toxicity in patients with relapsed/refractory Waldenstroms macroglobulinemia. An overall response rate of 33% (CR + PR + MR) was reported with an additional 61% of patients achieving stable disease (SD).

"The phase 2 data presented today further confirms pre-clinical results suggesting the promising activity of perifosine in Waldenstrom's macroglobulinemia," stated Dr. Ghobrial. "We are encouraged by the activity of single agent perifosine in the treatment of patients with advanced Waldenstrom's macroglobulinemia, and the manageable toxicity profile seen to date.

Michael Weiss, CEO of Keryx Biopharmaceuticals, commented "We are encouraged by this new data for perifosine, which continues to show activity across multiple forms of cancer. There is no FDA approved agent for the treatment of Waldenstroms macroglobulinemia and we believe that perifosine may offer a novel treatment option for these patients. We look forward to continuing to explore the potential for perifosine in the treatment of Waldenstroms macroglobulinemia as well as several other cancers, including multiple myeloma, renal cell carcinoma and brain cancer, both as a single agent and in combination with other novel agents."

Copies of the posters are available by request to Keryx Biopharmaceuticals.

KRX-0401 (Perifosine) Mechanism of Action and Profile

KRX-0401 (Perifosine) is a novel, potentially first-in-class, oral anti-cancer agent that modulates
'/>"/>

SOURCE Keryx Biopharmaceuticals, Inc.
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6

Related medicine technology :

1. Keryx Biopharmaceuticals to Present at William Blair & Company Small-Cap Growth Stock Conference
2. Keryx Biopharmaceuticals, Inc. Announces Positive Preliminary Phase 2 Data on KRX-0401 in Patients with Chemo-Insensitive Rare Sarcoma
3. Keryx Biopharmaceuticals, Inc. Announces Phase 1 and Phase 2 Data on KRX-0401 (Perifosine) in Patients with Relapsed/Refractory Multiple Myeloma at 49th Annual Meeting of American Society of Hematology
4. Keryx Biopharmaceuticals Completes SUN-MICRO Phase 3 Pivotal Trial
5. Keryx Biopharmaceuticals Announces that the SUN-MICRO Phase 3 Clinical Trial Failed to Meet its Primary Efficacy Endpoint
6. Keryx Biopharmaceuticals Announces Termination of SUN-MACRO Phase 4 Trial
7. Keryx Biopharmaceuticals, Inc. Announces Poster Presentation Highlighting Observed Clinical Activity of KRX-0401 (Perifosine) at the American Society of Clinical Oncology Meeting in Chicago, Illinois
8. Dendreon Announces Publication of Phase 1 Study Highlighting Immunologic and Clinical Activity of Lapuleucel-T (Neuvenge(R)) in Advanced Breast Cancer Patients
9. EDAP Announces Launch of Clinical Study Combining HIFU and Chemotherapy for Localized Aggressive High Risk Prostate Cancer
10. Cephalon Announces Positive Results from a Pivotal Study of FENTORA in Opioid-tolerant Patients with Non-cancer Breakthrough Pain
11. ADVENTRX Announces Fast Track Designation Granted By the FDA For CoFactor For the Treatment of Metastatic Colorectal Cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/10/2014)... July 10, 2014 Integrated Silicon Solution, Inc. ... memory and analog IC solutions, today announced that it ... 24, 2014, at 7:00 a.m. Pacific Time (10:00 a.m. ... the fiscal 2014 third quarter ended June 30, 2014. ... dial 1-888-556-4997 before 6:50 a.m. Pacific time on July ...
(Date:7/10/2014)... 10, 2014  Valeant Pharmaceuticals International, Inc. (NYSE: ... has completed the sale to Galderma of all rights ... held by Valeant for $1.4 billion in cash, pursuant ... recently completed its acquisition of Galderma. ... products to a company that is firmly committed to ...
(Date:7/10/2014)... -- CVS Caremark Corporation (NYSE: CVS ) today ... dividend of $0.275 (27.5 cents) per share on the corporation,s ... to holders of record on July 21, 2014. ... to helping people on their path to better health as ... States . Through the company,s more than 7,600 CVS/pharmacy ...
Breaking Medicine Technology:
(Date:7/11/2014)... Volunteers from Scientology Churches and Missions ... drug education lectures, forums and conferences, information stands, sports ... the world. , Drug abuse is an international epidemic. ... abuse of alcohol and illicit drugs costs more than ... productivity and healthcare. , In the face of ...
(Date:7/11/2014)... (PRWEB) July 11, 2014 Datalogic brings ... in improving sanitation hospital wide. With their new ... spread of disease, like the devastating MRSA, which claimed ... Gryphon GD4400-HC 2D and the Gryphon GM4400-HC ... barcodes and can even read barcodes off of troublesome ...
(Date:7/11/2014)... U.S. health officials have concluded that it,s highly unlikely ... a safety mishap last month. But, the U.S. ... a moratorium on the transfer of any dangerous germs ... report issued Friday, the CDC outlined several measures the ... doesn,t occur again. Last month, as many as 75 ...
(Date:7/11/2014)... Global enterprises today are shifting towards ... management activities. Managed services offer these global enterprises a ... slowdown resulted into rising operational costs to companies. The ... to be the global market driver for expanding the ... managed services market is estimated to grow from $142.75 ...
(Date:7/11/2014)... (July 10, 2014) Obese and overweight firefighters ... health care providers, according to new research from ... Houston (UTHealth). , National guidelines state that health ... importance of maintaining a healthy weight. Firefighters have ... the leading cause of line-of-duty deaths in firefighters. ...
Breaking Medicine News(10 mins):Health News:Scientologists Taking Action against Drug Abuse 2Health News:Scientologists Taking Action against Drug Abuse 3Health News:Stop Spreading Disease with the New Disinfectant-Ready Bar Code Scanner 2Health News:Stop Spreading Disease with the New Disinfectant-Ready Bar Code Scanner 3Health News:CDC Issues Tough Report on Anthrax Scare 2Health News:North America Managed Services Market Worth $68.65 Billion by 2018 - New Report by MicroMarket Monitor 2Health News:North America Managed Services Market Worth $68.65 Billion by 2018 - New Report by MicroMarket Monitor 3Health News:North America Managed Services Market Worth $68.65 Billion by 2018 - New Report by MicroMarket Monitor 4
... and hyperactivity disorder (ADHD) are more than three times ... dementia than those without, according to research in the ... . Researchers from Argentina confirmed the link during ... 149 healthy controls, matched by age, sex and education. ...
... HealthDay Reporter , MONDAY, Jan. 17 (HealthDay News) -- ... actually measure up, according to new research. Dermatologists ... protection from the sun,s ultraviolet rays and found only ... which can penetrate glass. "The vast majority of ...
... and people in the southern United States who were newly ... years experienced greater HIV/AIDS-related morbidity compared to men and people ... The findings, published in the February 15 issue of ... to improve the health of these populations in order to ...
... HealthDay Reporter , MONDAY, Jan. 17 (HealthDay ... You tend to befriend others with similar or complementary ... University of California, San Diego found that gene clusters ... predisposition to befriend others in the same geographic area. ...
... other illnesses and patient embarrassment may prevent dermatologists, ... examinations, according to a report in the January ... of the JAMA/Archives journals. However, dermatologists are significantly ... conduct such screenings. Skin cancer is the ...
... HealthDay Reporter , MONDAY, Jan. 17 (HealthDay News) ... to the development of psychological disorders such as depression, researchers ... are more likely to become addicted to video games (which ... a lot of hours playing these games, have trouble fitting ...
Cached Medicine News:Health News:Adult ADHD significantly increases risk of common form of dementia 2Health News:Adult ADHD significantly increases risk of common form of dementia 3Health News:Despite Claims, Many Daily Moisturizers Don't Shield Against Sun: Study 2Health News:Despite Claims, Many Daily Moisturizers Don't Shield Against Sun: Study 3Health News:Sex, race, and geography influence health outcomes following primary HIV infection 2Health News:Your Genes Help You Choose Your Friends, Study Says 2Health News:Your Genes Help You Choose Your Friends, Study Says 3Health News:Clinicians cite time, patient embarrassment as barriers to performing skin cancer exams 2Health News:Video Game 'Addiction' Tied to Depression, Anxiety in Kids 2Health News:Video Game 'Addiction' Tied to Depression, Anxiety in Kids 3
Zebras H 2824-Z Healthcare Starter Kit includes everything you need to start printing wristbands today: the H 2824-Z direct thermal printer, a pre-installed Media Adapter Guide, and a roll of adult-s...
... Hugs® system software presents only ... a familiar Windows-based PC environment. Up ... connected at other locations throughout the ... network (LAN). Nurses, security personnel and ...
... is designed to protect a wandering resident ... lost or injured. Such residents typically have ... have suffered a head injury., At-risk residents ... wrist or ankle, and points of exit ...
... be programmed to send hospital-defined ... device needs servicing, preventive maintenance ... patient or staff member needs ... ID-tag includes the current location ...
Medicine Products: