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Kendle Advances Early Stage Drug Development with ElMindA's Innovative Brain Network Activation Technology
Date:6/15/2010

EG-trained technician rather than requiring scanning time in MRI machines.  There are no limits to the number of scans or images that can be taken over a set amount time as EEG is completely non-invasive, allowing for assessments at multiple time points and multiple doses to determine the effects of novel drugs on brain function.  

"ElMindA's mission in developing BNA imaging was to revolutionize the diagnosis and treatment of brain-related pathologies by showing, for the first time, the dynamic connectivity and synchronization of electrophysiological networks within the brain," said Professor Amir Geva, Founder and Chief Technology Officer of ElMindA. "We are enabling researchers and physicians to truly observe the direct electrophysiology of the brain reacting to treatment in order to improve a wide range of therapies.  Kendle was the ideal partner to bring this exclusive technology to market because of their extensive early stage CNS experience."

The BNA technology is expected to accelerate research in such key areas as Alzheimer's disease, mild cognitive impairment, schizophrenia, pain, ADHD, depression, anxiety, sleep disorders and narcolepsy and can be adapted to any study of drugs expected to act on the central nervous system. BNA is ideal for SAD/MAD discovery, proof-of-concept and proof-of-mechanism studies, patient bridging and identifying select responder populations.  The highly-sensitive imaging also can capture dose-dependent changes in the brain, allowing for evaluation of drug-drug interactions and improved participant selection criteria.

"The technology has been targeted to early stage CNS drugs very early in their development, allowing us to literally see if and how a drug is working by evaluating cognition or subjective measures of response coupled with network activation patterns," noted Dr. Sel
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SOURCE Kendle International Inc.
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