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Karyopharm Therapeutics Inc. and Katholieke Universiteit Leuven Sign Exclusive Collaboration for the Discovery of Novel CRM1/Exportin 1 Inhibitors
Date:10/11/2011

founded by Drs. Sharon Shacham, Michael Kauffman, Giulio Draetta and Ronald DePinho in 2008.  Karyopharm completed a $20M Series A financing in October, 2010, and has won several grants/awards including a Biotech Investment Award by the Multiple Myeloma Research Foundation in 2010. Karyopharm's first program is directed towards the Selective Inhibition of Nuclear Export – its SINE program – targeting CRM1, the major nuclear export protein. By inhibiting the nuclear export of tumor suppressor proteins, Karyopharm's drug candidates force the activation of the cell's key tumor suppressor and anti-inflammatory  pathways including p53, p21, pRB, FoxO, and the inhibitor of NF-kB (i.e., IkB).  Karyopharm anticipates entering the clinic in 2012 with its first SINE for the treatment of various cancers.  The Company is also evaluating the use of SINE in autoimmune, viral and dermatologic disorders.  Karyopharm Therapeutics is located in Natick, Massachusetts.

About K.U.Leuven and the Rega Institute for Medical Research

K.U.Leuven, founded in 1425, is the largest university in Belgium, located in Leuven (Flanders), with a wealth of excellent research and a strong reputation and track-record in technology transfer through K.U.Leuven Research & Development (LRD). More than 6,000 researchers from more than 120 countries concentrate on curiosity-driven and ground-breaking strategic research, as well as targeted and demand-driven research. The Rega Institute for Medical Research is a biomedical research institute of K.U.Leuven that comprises the Laboratory of Virology and Chemotherapy. Many patients have already been treated with drugs that were initially discovered at the Rega Institute.

CONTACT: Michael Kauffman, +1-617-803-0097, mkauffman@karyopharm.com


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