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Karyopharm Therapeutics Inc. Appoints Michael Kauffman, MD, PhD, as Chief Executive Officer
Date:1/5/2011

NEWTON, Mass., Jan. 5, 2011 /PRNewswire/ -- Karyopharm Therapeutics Inc., a pioneer and leader in the new field of nuclear transport modulators, announces the recruitment of a highly experienced cancer drug developer, Michael G. Kauffman, MD, PhD, as its Chief Executive Officer. Dr. Kauffman will join Sharon Shacham, PhD, MBA, the Company's CSO and Head of Research and Development, as its executive management team. Kauffman's appointment follows the $20M Series A financing announced in November, 2010.

Karyopharm's lead program is focused on novel, small molecule SINE (Selective Inhibitors of Nuclear Export) targeting CRM1. CRM1 is a key linchpin governing the nuclear export of multiple tumor suppressors and growth regulatory proteins, providing a strategic point of therapeutic intervention for a diverse array of cancers. On joining Karyopharm, Kauffman, also a Karyopharm co-founder and Director, commented, "This is a rare opportunity to join a company firing on all cylinders -- strong funding, extremely promising lead compounds with broad and potent in vivo anti-tumor activity, a seasoned and committed scientific and development team, and leading cancer consultants. The clinical application, enabled further by sophisticated proprietary pharmacogenomic insights, offers the potential to transform cancer treatment with a new class of effective and well tolerated agents."  

According to Karyopharm Co-Founder, Board Member and Harvard cancer scientist Ronald A. DePinho, M.D., "The recruitment of Dr. Kauffman represents a major advance for Karyopharm which is now poised to bring a powerful new class of cancer medicines for diverse cancers and other diseases. Michael brings an extraordinary record of professional achievement in the development of major novel cancer drugs and in building and managing highly successful biotechnology companies."

Board member and clinical advisor Dr. Mansoor Raza Mirza commented, "It is depressing to see my patien
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SOURCE Karyopharm Therapeutics Inc.
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