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Karolinska Study Published in Cancer Epidemiology, Biomarkers & Prevention Validates Strong Agreement for VolparaDensity across Mammography Systems from Multiple Manufacturers
Date:7/28/2014

c AB). Volumetric breast density was measured for each participant using VolparaDensity. Study participants also donated blood for genotyping and filled out a detailed questionnaire.

Results demonstrated that in a high-throughput setting VolparaDensity performs well and in accordance with the behavior of established density measures. Volumetric density was positively associated with nulliparity (never having given birth), age at first birth, hormone use, benign breast disease and family history of breast cancer, and negatively with age and postmenopausal status. Importantly, the method showed good agreement by side and by view and distributions of volume density were similar across the different mammography systems. Based on the results, researchers concluded that automated measurement of volumetric mammographic density using VolparaDensity is a promising tool for widespread breast cancer risk assessment.

"One of the limitations of current screening strategies," according to Volpara Solutions Chief Scientist and CEO, Dr. Ralph Highnam, "is that they are based solely on age, ignoring the fact that a woman's lifetime risk is determined by other common risk factors. After age, mammographic density is the strongest breast cancer risk factor. As a result of the Karolinska's study, VolparaDensity's volumetric assessment of mammographic density is continuing to display its promise as a highly effective tool for optimizing screening programs where resources and extra imaging modalities can be targeted to those with the highest density.

"The KARMA study is one of the best organized and most exciting studies that we are participating in globally. This validation of VolparaDensity for consistency is a great starting point for a whole range of projects we aim to complete with KARMA as we pursue our joint aim of reducing the mortality and incidence of breast cancer," said Dr. Highnam.

Cleared by the FDA, HealthCa
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