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Karolinska Institutet to Test Vical's Vaxfectin(R) Adjuvant With Preventive Vaccine against HIV Under Sponsorship of Swedish Institute for Infectious Disease Control
Date:8/19/2008

king statements include statements about the Karolinska Institutet's and the SMI's plans for a prime-boost HIV vaccine clinical trial, the potential effect of the company's Vaxfectin(R) adjuvant and Biojector(R) 2000 needle-free injection system on vaccine performance, and the design and potential benefits of HIV DNA vaccines generally. Risks and uncertainties include whether Vical, the Karolinska Institutet the SMI or others will continue development of the HIV vaccine; whether the SMI will sponsor and the Karolinska Institutet will complete preclinical testing and conduct a Phase 1 trial using a Vaxfectin(R)-formulated DNA prime-MVA boost vaccination regimen; whether such trial, if conducted, will use the Biojector(R) 2000 needle-free injection system to deliver the DNA priming vaccine; whether Vaxfectin(R) will optimize the DNA vaccine priming of immune responses against the specific HIV vaccine targets and increase the performance of, or eliminate the need for, the MVA vaccine boost; whether Vaxfectin(R)-formulated DNA priming vaccines will increase the breadth and magnitude of immune responses to the prime-boost regimen; whether the prime-boost vaccine regimen will be effective in protecting humans against HIV infection or disease; whether the HIV vaccine will achieve the safety and immunogenicity endpoints in the Phase 1 trial; whether Vical or its collaborative partners will seek or gain approval to market any product candidates; whether Vical or its collaborative partners will succeed in marketing any product candidates; and additional risks set forth in the company's filings with the Securities and Exchange Commission. These forward-looking statements represent the company's judgment as of the date of this release. The company disclaims, however, any intent or obligation to update these forward-looking statements.

Contact: Alan R. Engbring

(858) 646-1127

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