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Karolinska Institutet to Test Vical's Vaxfectin(R) Adjuvant With Preventive Vaccine against HIV Under Sponsorship of Swedish Institute for Infectious Disease Control
Date:8/19/2008

thetic versions of genes encoding internal and surface proteins from different HIV subtypes. The combination is designed to provide protection against the most prevalent HIV strains circulating in Europe, Africa and The Americas. The prime-boost approach uses two vaccine components given at different times. The two vaccine components differ in how the genes are packaged. The DNA prime vaccine component contains only the specific gene sequences in a plasmid DNA ring, and cannot reconstitute into an infectious virus. The HIV DNA vaccine was developed by the SMI and the Karolinska Institutet in Sweden. The viral vector boost vaccine component uses a Modified Vaccinia Ankara (MVA) virus (the virus that causes cowpox) to shuttle the same non-infectious gene sequences into the body. The boost vaccine component was developed by the NIH and Walter Reed Army Institute of Research, and does not use an adjuvant.

In the first Phase 1 trial, the DNA priming vaccines were delivered with the Biojector(R) 2000 needle-free injection system into either the muscle or the skin. In the next trial, the Vaxfectin(R)-formulated DNA vaccines would be delivered with the Biojector(R) 2000 needle-free injection system into the skin. The MVA boost vaccine is delivered by needle and syringe.

Recently reported preliminary results from Vical's Phase 1 trial of the company's H5N1 pandemic influenza DNA vaccines marked the first time the Vaxfectin(R) adjuvant was tested in humans. Some cohorts were vaccinated by needle and syringe into the muscle and some with the Biojector(R) 2000 needle-free injection system into the muscle. The proposed KI/SMI study would mark the first human test of a Vaxfectin(R)-formulated vaccine delivered by needle-free injection into the skin. Intradermal delivery by needle-free injection and use of the Vaxfectin(R) adjuvant may increase the immune responses to the vaccine.

About Vaxfectin(R)

Vaxfectin(R) was designed by Vical to increase the imm
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SOURCE Vical Incorporated
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