Navigation Links
Karolinska Institutet to Test Vical's Vaxfectin(R) Adjuvant With Preventive Vaccine against HIV Under Sponsorship of Swedish Institute for Infectious Disease Control
Date:8/19/2008

thetic versions of genes encoding internal and surface proteins from different HIV subtypes. The combination is designed to provide protection against the most prevalent HIV strains circulating in Europe, Africa and The Americas. The prime-boost approach uses two vaccine components given at different times. The two vaccine components differ in how the genes are packaged. The DNA prime vaccine component contains only the specific gene sequences in a plasmid DNA ring, and cannot reconstitute into an infectious virus. The HIV DNA vaccine was developed by the SMI and the Karolinska Institutet in Sweden. The viral vector boost vaccine component uses a Modified Vaccinia Ankara (MVA) virus (the virus that causes cowpox) to shuttle the same non-infectious gene sequences into the body. The boost vaccine component was developed by the NIH and Walter Reed Army Institute of Research, and does not use an adjuvant.

In the first Phase 1 trial, the DNA priming vaccines were delivered with the Biojector(R) 2000 needle-free injection system into either the muscle or the skin. In the next trial, the Vaxfectin(R)-formulated DNA vaccines would be delivered with the Biojector(R) 2000 needle-free injection system into the skin. The MVA boost vaccine is delivered by needle and syringe.

Recently reported preliminary results from Vical's Phase 1 trial of the company's H5N1 pandemic influenza DNA vaccines marked the first time the Vaxfectin(R) adjuvant was tested in humans. Some cohorts were vaccinated by needle and syringe into the muscle and some with the Biojector(R) 2000 needle-free injection system into the muscle. The proposed KI/SMI study would mark the first human test of a Vaxfectin(R)-formulated vaccine delivered by needle-free injection into the skin. Intradermal delivery by needle-free injection and use of the Vaxfectin(R) adjuvant may increase the immune responses to the vaccine.

About Vaxfectin(R)

Vaxfectin(R) was designed by Vical to increase the imm
'/>"/>

SOURCE Vical Incorporated
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3 4 5

Related medicine technology :

1. Karolinska Institute to Test Vicals Vaxfectin(R) Adjuvant with Preventive Vaccine against HIV Under Sponsorship of Swedish Institute for Infectious Disease Control
2. Nventa Develops Proprietary Vaccine Adjuvant
3. Study Supports Possible Use of Leukine(R) as a Potential Adjuvant Therapy for High-Risk Melanoma Patients
4. Iomai Receives HHS Approval to Begin Phase 2 Trial of H5N1 Influenza Adjuvant Patch
5. Vical Demonstrates Dose-sparing of Protein-based H5N1 Influenza Vaccine With Vaxfectin(TM) Adjuvant
6. Positive Xeloda(R) Five-Year Overall Survival Study Data in the Adjuvant Treatment of Colon Cancer Presented at Leading European Cancer Meeting
7. CEL-SCI Presents Data for CEL-1000 as a Vaccine Adjuvant with Recombinant Hepatitis B Virus Protein
8. U.S. Preventive Medicine: Employers Can Help Workers Avoid Heart Attacks
9. Inhaled Steriods Used as Preventive Treatment Post 9/11
10. U.S. Preventive Medicine Acquires Specialty Disease Management
11. Sanofi Pasteur Shipping First Doses of Influenza Vaccine for the 2008-2009 Season in the US
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/28/2014)... , July 28, 2014  Isis Pharmaceuticals, Inc. (NASDAQ: ... Second Quarter 2014 Financial Results and Highlights Conference CallWhen:Monday, ... PTWhere: www.isispharm.com How:Live on the Internet. Simply log ... to participate during the live event, a replay of ... at www.isispharm.com . ABOUT ISIS PHARMACEUTICALS, ...
(Date:7/28/2014)... -- CTI BioPharma Corp. (CTI) (NASDAQ and MTA: CTIC) ... 2014 financial results on Monday, August 4, 2014, after ... announcement, members of the management team will host a ... a general corporate update at 4:30 p.m. EDT (1:30 ... as follows: Monday, August 4 1:30 ...
(Date:7/25/2014)... 25, 2014  In today,s marketplace, launching multiple products ... - as is managing a portfolio of products in ... possible - or even preferable - to pool resources ... you combine resources and activities, and what marketing and ... are just a few of the dilemmas facing pharmaceutical ...
Breaking Medicine Technology:Webcast Alert: Isis Pharmaceuticals' Second Quarter 2014 Financial Results Conference Call 2CTI BioPharma to Report Second Quarter 2014 Financial Results on August 4, 2014 2Using Promotional Efficiency to Support Multiple Products and Indications in the Pharmaceutical Marketplace 2
... , SAN DIEGO, Nov. 18 Rules-Based ... biomarker alliance and services agreement with Covance Inc. (NYSE: ... with a powerful combination of biomarker technologies and services for ... will use RBM as its exclusive third-party provider of multiplexed ...
... , NASHVILLE, Tenn., Nov. 17 Emdeon (NYSE: ... cycle management solutions, today announced that it will participate in the ... 1 to 2, 2009 in New York. , The "fireside chat", ... time on Tuesday, December 1, 2009. A live audio webcast ...
Cached Medicine Technology:Rules-Based Medicine Forms Biomarker Alliance With Covance Inc. 2Rules-Based Medicine Forms Biomarker Alliance With Covance Inc. 3
(Date:7/28/2014)... (PRWEB) July 28, 2014 The ... the majority of professionals engaged in the field ... the Transplantation and Immunology Research Network ... and immunology research. As modern organ transplantation continues ... network that could provide more opportunities for physicians, ...
(Date:7/28/2014)... (PRWEB) July 28, 2014 At some point ... situation where they’re forced to contact the authorities. Distinguishing ... difficult than it initially seems. , Not every dangerous situation ... get stolen, a person get mugged, or a bank get ... obvious, leading onlookers to be more passive than they otherwise ...
(Date:7/28/2014)... University of Texas Health Science Center at San Antonio, the ... of pills that cures 9 of 10 hepatitis C patients. ... or without ribavirin, cured 93 percent of patients in 12 ... study published today in The Lancet . , ... Lawitz, M.D., clinical professor in the School of Medicine at ...
(Date:7/28/2014)... HealthDay Reporter MONDAY, July 28, ... have a slightly increased risk of potentially fatal blood ... report. Doctors have previously suspected that babies born ... of deep vein thrombosis and pulmonary embolism, two serious ... researchers noted in background information. This new study ...
(Date:7/28/2014)... 2014A two-step decision tree analysis, incorporating Donabedian,s model, ... the many available quality standards, guidelines, recommendations and ... international quality standards for radiation therapy, according to ... of Practical Radiation Oncology (PRO), the ... for Radiation Oncology (ASTRO). , Guidelines, recommendations and ...
Breaking Medicine News(10 mins):Health News:American Society of Transplantation (AST) Launches Transplantation and Immunology Research Network (TIRN); Aims to Expand Research Collaboration & Funding 2Health News:American Society of Transplantation (AST) Launches Transplantation and Immunology Research Network (TIRN); Aims to Expand Research Collaboration & Funding 3Health News:Take Action To Protect Your Fellow Citizens 2Health News:Take Action To Protect Your Fellow Citizens 3Health News:New pill regimens published in The Lancet cure hardest-to-treat hepatitis C patients 2Health News:Preemies May Have Higher Risk of Blood Clots, Even as Adults 2Health News:Preemies May Have Higher Risk of Blood Clots, Even as Adults 3Health News:Two-step decision tree analysis helps inform updates of RT best practices, quality standards 2Health News:Two-step decision tree analysis helps inform updates of RT best practices, quality standards 3
... Consumer Watchdog sent a letter to Senator ... expressing their profound disappointment that consumer advocates had ... the Massachusetts senator to formulate health care reform ... recent national polls showing the public overwhelming opposed ...
... Results To Offer New Insights on How Well Asthma ... The American Lung Association of New England (ALANE) has ... offer an online survey and corresponding report that will ... being controlled and encourage them to discuss the results ...
... ROCKVILLE, Md., Feb. 20 /PRNewswire-Asia/ -- Synutra,International, ... a leading infant formula,company in China, and ... products,for infants, children and adults, today issued ... permit numbers in a published list of ...
... eFoodSafety.com, Inc., (OTC Bulletin Board: EFSF) an emerging ... aesthetics, dermatology, environmental and nutraceutical products, outlined its ... 30, 2010 during its regularly scheduled monthly investor ... eFoodSafety.com intends to increase revenues by improving the ...
... Many people seek answers to questions of motivation and ... by Justin Honaman employs lessons learned in his career ... an effort to help others direct their energies and ... chapters of "Make It Happen" that personal branding is ...
... the world,s largest autism science and advocacy organization, is teaming up ... series "Wow! Wow! Wubbzy!" - to promote World Autism Awareness Day ... autism as a worldwide health crisis. , ... New ...
Cached Medicine News:Health News:Consumer Watchdog to U.S. Senate: Don't Leave Consumers Out of Health Reform Debate, Public Opposes Mandatory Purchases of Private Insurance & Supports Opening Medicare to Everyone 2Health News:American Lung Association of New England Launches Online Asthma Control Test 2Health News:American Lung Association of New England Launches Online Asthma Control Test 3Health News:American Lung Association of New England Launches Online Asthma Control Test 4Health News:Synutra Issues Statement Regarding Market Rumors on Revocation of its Production Certification 2Health News:Synutra Issues Statement Regarding Market Rumors on Revocation of its Production Certification 3Health News:eFoodSafety.com Provides Revenue Guidance for FY 2010 2Health News:eFoodSafety.com Provides Revenue Guidance for FY 2010 3Health News:Business Strategist Applies Corporate Experience to Self-Help: 'Make It Happen' 2Health News:Autism Speaks and 'Wow! Wow! Wubbzy!' Team Up to Shine a Spotlight on World Autism Awareness Day 2Health News:Autism Speaks and 'Wow! Wow! Wubbzy!' Team Up to Shine a Spotlight on World Autism Awareness Day 3Health News:Autism Speaks and 'Wow! Wow! Wubbzy!' Team Up to Shine a Spotlight on World Autism Awareness Day 4
The FastPack system is a state of the art, lab quality immunoassay system designed for rapid results. The FastPack system delivers lab-quality sensitivity at a fraction of the cost of laboratory....
... When you need quick, accurate, convenient, and ... compact VITROS DT60 II Chemistry System. This ... and back-up laboratory testing requirements. And it ... -- better patient outcomes, reduced overall costs, ...
... In an effort to improve on ... hormones, toxicology, abused drugs, and immunosuppressants ... 1991 which incorporates random access capabilities. ... has undergone several important changes in ...
AxSYM Plus provides cutting-edge ergonomics and smart new features that mean increased ease-of-use and enhanced reliability. Also, advanced software means less operator intervention and high-integrit...
Medicine Products: