Navigation Links
Karmanos Researchers Find Non-Toxic Agents Added to Conventional Chemotherapy Decrease Survival of Colon Cancer Cells
Date:4/13/2008

SAN DIEGO, April 13 /PRNewswire-USNewswire/ -- Researchers from the Barbara Ann Karmanos Cancer Institute in Detroit today presented findings showing that adding curcumin or resveratrol to conventional chemotherapy could be effective in preventing the growth of chemo-resistant colon cancer cells. The poster presentation was delivered at the American Association for Cancer Research (AACR) Annual Meeting in San Diego, CA.

(http://www.newscom.com/cgi-bin/prnh/20071106/KARMANOSCANCERINSTITUTELO GO )

Anti-inflammatory properties and other health benefits have long been associated with curcumin and resveratrol. Curcumin, from the ginger family, is in the Indian curry spice turmeric and is prevalent throughout India and Southeast Asia. Resveratrol is produced naturally by plants and is found in the skin of red grapes and in peanuts.

Karmanos researchers investigated whether the addition of non-toxic substances curcumin and resveratrol to chemotherapy (FOLFOX) would decrease the survival of colon cancer cells. Studies confirmed that both are effective and inhibit the growth of new colon cancer cells, with curcumin appearing to be superior.

Adhip Majumdar, Ph.D., D.Sc., Bhaumik B. Patel, M.D., Deep-Shikha Gupta, and Vivek Sengupta from Karmanos and Wayne State University, performed a 48-hour treatment of colon cancer HCT-116 or HT-29 cells with FOLFOX (25 micrometers 5-FU+0.625 micrometers oxaliplatin). When FOLFOX surviving colon cancer cells were treated for another 48-hours with FOLFOX together with curcumin or resveratrol, the combination therapy showed a better response rate.

"Patients with advanced colon cancer often have a cancer recurrence resulting from cancer cells that survive chemotherapy. This research could eventually lead to a more robust therapy, particularly if we can lower the dose of chemotherapy, and add non-toxic agents," said Dr. Majumdar.

"Some day the addition of curcumin or resveratrol could become a treatment strategy for colon cancer patients and help prolong life. Currently, despite advances in medicine, mortality rates remain unacceptably high for late stage disease. Our work is helping to lay the ground work for future clinical trials," added Dr. Patel.

About the Barbara Ann Karmanos Cancer Institute

Located in mid-town Detroit, MI, the Barbara Ann Karmanos Cancer Institute is one of 39 National Cancer Institute-designated comprehensive cancer centers in the United States. Caring for more than 6,000 new patients annually on a budget of $216 million, conducting more than 700 cancer-specific scientific investigation programs and clinical trials, the Karmanos Cancer Institute is among the nation's best cancer centers. Through the commitment of 1,000 staff, including nearly 300 faculty members, and supported by thousands of volunteer and financial donors, the Institute strives to prevent, detect and eradicate all forms of cancer. John C. Ruckdeschel, M.D., is the Institute's president and chief executive officer. For more information call 1-800-KARMANOS or go to http://www.karmanos.org.

American Association for Cancer Research

The mission of the American Association for Cancer Research is to prevent and cure cancer. Founded in 1907, AACR is the world's oldest and largest professional organization dedicated to advancing cancer research. The AACR Annual Meeting attracts more than 17,000 participants who share the latest discoveries and developments in the field.


'/>"/>
SOURCE Karmanos Cancer Institute
Copyright©2008 PR Newswire.
All rights reserved

Related medicine technology :

1. Molecular Science Could Further Improve Leukemia Survival, Say St. Jude Researchers
2. Evanston Northwestern Healthcare Researchers Explain Effects of Large-Scale, Universal MRSA Surveillance Program That Supports Expanded Intervention
3. Universite de Montreal Researchers Simulate Worlds Largest Heart Model Using SGI Technology
4. Researchers Use Magnetism to Target Cells to Animal Arteries
5. Novel Mechanism for Long-Term Learning Identified by Carnegie Mellon Researchers
6. Researchers Train the Immune System to Deliver Virus That Destroys Cancer in Lab Models
7. Researchers Develop New Procedure to Screen All 46 Human Chromosomes to Identify Abnormalities in Embryos
8. Potential Breakthrough Cancer Treatment Emerges from MIPS-Funded Clinical Trial Teaming CSA Medical Inc. and University of Maryland Researchers
9. Researchers Report First Successful Treatment of Chronic Traumatic Brain Injury
10. 454 Sequencing(TM) in Science Today: Researchers Uncover a Genetic Basis for Different Social Behaviors in Wasps
11. U. of Md. Researchers to Develop Devices to Revolutionize Drug Research
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/24/2017)... YORK , March 24, 2017 ... and Equipment stocks, which are: Neovasc Inc. (NASDAQ: NVCN), Hologic ... Heart Inc. (NASDAQ: SSH ). These companies are ... its prior gains on Thursday, March 23 rd , 2017, ... afternoon, while shares of health care companies in the S&P ...
(Date:3/24/2017)...  Mirabilis Medical, a Seattle ... surgery, announced today CE Mark authorization for marketing ... fibroids throughout the European Union.  The company simultaneously ... US Food and Drug Administration to begin a ... United States.  The Mirabilis System combines high-speed therapeutic ...
(Date:3/23/2017)... MOBILE, Ala. , March 23, 2017 Mosaic Life Care, based in ... automate the patient registration process across its network of 58 clinics, located in 22 ... constantly seeking new and innovative ways to improve the delivery of health care to ... Continue Reading ... Mosaic Life Care St. Joseph ...
Breaking Medicine Technology:
(Date:3/24/2017)... ... ... “Vintage and Harvest A Cultivation of Christian Love” is the creation of ... Carolina with his wife, Anna Marie. He and his wife are the proud parents ... the author of “Shadow and Substance.” , “Love, the agape kind, is seen as ...
(Date:3/24/2017)... ... , ... “The Adventures of Joey, The Dog Who Barks at Puddles”: a ... to the fullest, as God intended. “The Adventures of Joey, The Dog Who Barks ... pursuing her passion for writing, especially about truth and human behavior. , Published by ...
(Date:3/23/2017)... ... March 23, 2017 , ... A recent report from ... into teacher preparation programs. The NCTQ report suggests, based on a review of GPA ... significantly improve teacher quality in the U.S. It argues that this higher bar should ...
(Date:3/23/2017)... ... 2017 , ... Demonstrating their commitment to improving health and ... have been awarded national accreditation through the Public Health Accreditation Board ... of communities across the nation whose health departments meet rigorous national standards for ...
(Date:3/23/2017)... , ... March 23, 2017 , ... ... City Convention Center at 10 North Broadway Avenue, will be an educational and ... relevant, practical instruction in the management of chronic pain. , Oklahoma is in ...
Breaking Medicine News(10 mins):