Navigation Links
Karmanos Researchers Find Non-Toxic Agents Added to Conventional Chemotherapy Decrease Survival of Colon Cancer Cells
Date:4/13/2008

SAN DIEGO, April 13 /PRNewswire-USNewswire/ -- Researchers from the Barbara Ann Karmanos Cancer Institute in Detroit today presented findings showing that adding curcumin or resveratrol to conventional chemotherapy could be effective in preventing the growth of chemo-resistant colon cancer cells. The poster presentation was delivered at the American Association for Cancer Research (AACR) Annual Meeting in San Diego, CA.

(http://www.newscom.com/cgi-bin/prnh/20071106/KARMANOSCANCERINSTITUTELO GO )

Anti-inflammatory properties and other health benefits have long been associated with curcumin and resveratrol. Curcumin, from the ginger family, is in the Indian curry spice turmeric and is prevalent throughout India and Southeast Asia. Resveratrol is produced naturally by plants and is found in the skin of red grapes and in peanuts.

Karmanos researchers investigated whether the addition of non-toxic substances curcumin and resveratrol to chemotherapy (FOLFOX) would decrease the survival of colon cancer cells. Studies confirmed that both are effective and inhibit the growth of new colon cancer cells, with curcumin appearing to be superior.

Adhip Majumdar, Ph.D., D.Sc., Bhaumik B. Patel, M.D., Deep-Shikha Gupta, and Vivek Sengupta from Karmanos and Wayne State University, performed a 48-hour treatment of colon cancer HCT-116 or HT-29 cells with FOLFOX (25 micrometers 5-FU+0.625 micrometers oxaliplatin). When FOLFOX surviving colon cancer cells were treated for another 48-hours with FOLFOX together with curcumin or resveratrol, the combination therapy showed a better response rate.

"Patients with advanced colon cancer often have a cancer recurrence resulting from cancer cells that survive chemotherapy. This research could eventually lead to a more robust therapy, particularly if we can lower the dose of chemotherapy, and add non-toxic agents," said Dr. Majumdar.

"Some day the addition of curcumin or resveratrol could become a treatment strategy for colon cancer patients and help prolong life. Currently, despite advances in medicine, mortality rates remain unacceptably high for late stage disease. Our work is helping to lay the ground work for future clinical trials," added Dr. Patel.

About the Barbara Ann Karmanos Cancer Institute

Located in mid-town Detroit, MI, the Barbara Ann Karmanos Cancer Institute is one of 39 National Cancer Institute-designated comprehensive cancer centers in the United States. Caring for more than 6,000 new patients annually on a budget of $216 million, conducting more than 700 cancer-specific scientific investigation programs and clinical trials, the Karmanos Cancer Institute is among the nation's best cancer centers. Through the commitment of 1,000 staff, including nearly 300 faculty members, and supported by thousands of volunteer and financial donors, the Institute strives to prevent, detect and eradicate all forms of cancer. John C. Ruckdeschel, M.D., is the Institute's president and chief executive officer. For more information call 1-800-KARMANOS or go to http://www.karmanos.org.

American Association for Cancer Research

The mission of the American Association for Cancer Research is to prevent and cure cancer. Founded in 1907, AACR is the world's oldest and largest professional organization dedicated to advancing cancer research. The AACR Annual Meeting attracts more than 17,000 participants who share the latest discoveries and developments in the field.


'/>"/>
SOURCE Karmanos Cancer Institute
Copyright©2008 PR Newswire.
All rights reserved

Related medicine technology :

1. Molecular Science Could Further Improve Leukemia Survival, Say St. Jude Researchers
2. Evanston Northwestern Healthcare Researchers Explain Effects of Large-Scale, Universal MRSA Surveillance Program That Supports Expanded Intervention
3. Universite de Montreal Researchers Simulate Worlds Largest Heart Model Using SGI Technology
4. Researchers Use Magnetism to Target Cells to Animal Arteries
5. Novel Mechanism for Long-Term Learning Identified by Carnegie Mellon Researchers
6. Researchers Train the Immune System to Deliver Virus That Destroys Cancer in Lab Models
7. Researchers Develop New Procedure to Screen All 46 Human Chromosomes to Identify Abnormalities in Embryos
8. Potential Breakthrough Cancer Treatment Emerges from MIPS-Funded Clinical Trial Teaming CSA Medical Inc. and University of Maryland Researchers
9. Researchers Report First Successful Treatment of Chronic Traumatic Brain Injury
10. 454 Sequencing(TM) in Science Today: Researchers Uncover a Genetic Basis for Different Social Behaviors in Wasps
11. U. of Md. Researchers to Develop Devices to Revolutionize Drug Research
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/10/2017)... Oct. 10, 2017   West Pharmaceutical Services, Inc. ... for injectable drug administration, today shared the results of ... for improving the intradermal administration of polio vaccines. The ... Summit in May 2017 by Dr. Ondrej Mach ... World Health Organization (WHO), and recently published in the ...
(Date:10/4/2017)... Mass. , Oct. 4, 2017 ... of single-use, self-contained, illuminating medical devices, today announced ... National Health Surveillance Agency (or Agência Nacional de ... The first single-use, cordless surgical retractor with integrated ... provides optimal access, illumination and exposure of a ...
(Date:10/2/2017)... COPENHAGEN, Denmark , Oct. 2, 2017 The ... tool in the struggle to reverse the tide of prescription ... plan for regulating their medicine intake and stepping down their ... is set to launch in December 2017; the first 100,000 ... access. Learn more at http://www.rebound-solution.com/ ...
Breaking Medicine Technology:
(Date:10/13/2017)... ... October 13, 2017 , ... Ellevate Network, the leading network for professional ... action towards gender equality at their inaugural Summit in New York City in June. ... a social audience of over 3 million. To watch the Mobilize Women video, ...
(Date:10/13/2017)... ... , ... “The Journey: From the Mountains to the Mission Field”: the story ... the Philippines. “The Journey: From the Mountains to the Mission Field” is the creation ... has taught all ages and currently teaches a class of ladies at her church, ...
(Date:10/12/2017)... WAUSAU, Wis. (PRWEB) , ... October 12, 2017 ... ... formulated standard products to meet the demand of today’s consumer and regulatory authorities ... team of probiotic experts and tested to meet the highest standard. , ...
(Date:10/12/2017)... ... 2017 , ... Dr. Parsa Mohebi, the Los Angeles based ... the newly revamped Cosmetic Town journal section, featuring articles written by ... as Follicular Unit Extraction (FUE). , Dr. Mohebi says “I enjoy ...
(Date:10/12/2017)... ... October 12, 2017 , ... Health Literacy Innovations (HLI), ... software tool, and the Cancer Patient Education Network (CPEN), an independent professional organization ... a new strategic alliance. , As CPEN’s strategic partner, HLI will help ...
Breaking Medicine News(10 mins):