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Karmanos Cancer Institute Researchers Study Bisphosphonates and Their Affect on Early Stage Breast Cancer
Date:6/5/2010

hosphonate use in an adjuvant setting. Dr. Nahleh said the next step is to conduct more clinical and pre-clinical trials on bisphosphonates on nonmetastatic breast cancer patients and understanding the effects of these drugs on the different types of breast cancer.

Dr. Nahleh said that extensive research was undertaken by Ashish Bhargava, M.D., a resident of Internal Medicine at Wayne State University School of Medicine and Kavita Nirmal, M.D., who at the time of the study was serving a fellowship in the Hematology/Oncology Department at Wayne State University School of Medicine. Judith Abrams, Ph.D., director of the Biostatistics Core at Karmanos and professor of Internal Medicine at Wayne State University Medical Center, and John Graff, Ph.D., MS, former epidemiologist at the Karmanos Cancer Institute, also assisted in the study.

"I hope this study will open venues for more confirmatory research to be conducted," she said. "That's the main question that needs to be answered – does nitrogen-containing bisphosphonates cause a lower survival rate in some women with nonmetastatic breast cancer and which group of patients can be affected?"

Located in mid-town Detroit, Michigan, the Barbara Ann Karmanos Cancer Institute is one of 40 National Cancer Institute-designated comprehensive cancer centers in the United States. Caring for nearly 6,000 new patients annually on a budget of $216 million, conducting more than 700 cancer-specific scientific investigation programs and clinical trials, Karmanos is among the nation's best cancer centers. Through the commitment of 1,00
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SOURCE Barbara Ann Karmanos Cancer Institute
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