Navigation Links
Karmanos Cancer Institute Researchers Present Breast Cancer Advancements at Conference
Date:4/20/2009

Dr. Burger says the findings offer particular hope to those women battling triple-negative breast cancer.

"We could now find a way to treat every kind of invasive, metastatic breast cancer, the ER-positive and ER-negative types with AFP464," she said. "The synergism is very impressive. We always knew vorinostat can reprogram the expression of cancer cells."

AFP464 has been in Phase I clinical trial for the last year and a half, where doses were given to patients with solid tumors. Dr. Burger says the next step is to take the anti-cancer agent to the second phase, where researchers administer to triple-negative breast cancer patients the drug alone or in combination with vorinostat. She expects that to occur in the next year and said that Karmanos could host one of those second-phase trials.

"We are currently conducting animal experiments with the single agents and the drug combination," Dr. Burger said. "Triple-negative breast cancers might respond against that drug (AFP464)."

Triple-negative breast cancer afflicts mostly young women under the age of 40 and is more prevalent in the African-American community. About 182,460 women in the United States were diagnosed with invasive breast cancer in 2008 and about 40,480 will die from the disease, according to the American Cancer Society. Dr. Burger said that about 14 percent to 18 percent of breast cancer cases are triple-negative.

She expects that this research could translate to real-world applications in the next five years.

"These are targeted agents that are being tested," Dr. Burger said. "Having a drug available to treat triple-negative breast cancer would be a major step in fighting this disease."

Located in mid-town Detroit, MI, the Barbara Ann Karmanos Cancer Institute is one of 40 National Cancer Institute-designated comprehensive cancer centers in the United States. C
'/>"/>

SOURCE Karmanos Cancer Institute
Copyright©2009 PR Newswire.
All rights reserved

Page: 1 2 3

Related medicine technology :

1. DNA Vaccine Developed at the Karmanos Cancer Institute Fights HER2-Positive Cancers
2. Karmanos Doctors Urge Increased Screening for Previously Treated Lung Cancer Patients, Especially Young Women
3. Karmanos Cancer Institute Researchers Show Phase I Immunotherapy with Armed T Cells Improve Overall Survival of Metastatic Breast Cancer Patients
4. Karmanos Cancer Institute Research Supports Role of Inflammation to Determine Lung Cancer Risk, Particularly in African-American Women
5. Karmanos Researchers Study the Impact of Galectin-3 on Breast Cancer Disparity in Caucasian and Asian Women
6. Karmanos Researchers Find Non-Toxic Agents Added to Conventional Chemotherapy Decrease Survival of Colon Cancer Cells
7. Muscadine Grape Skin Dietary Supplement Protects against Cancer Therapy Radiation Side Effects
8. Peregrine Pharmaceuticals Reports Positive Preliminary Data From Phase II Bavituximab Lung Cancer Trial
9. New Australian Drug Holds Hope of Major Breakthrough in Treating Terminal Blood Cancers
10. Genetic Source of Rare Childhood Cancer Found; Gene is Implicated in Other Cancers
11. Trubion Pharmaceuticals, Inc. Announces Upcoming Presentation at the 2009 American Association of Cancer Research Annual Meeting
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/1/2015)... -- Lee Tran & Liang LLP (LTL), ... and Yik Yak co-founder disputes, announced today ... most promising biotechnology start-ups in the country, Resilience Therapeutics, ... Sabados .  LTL represents Veronica Sara Weiner , ... fellow scientist at the Massachusetts Institute of Technology.      ...
(Date:6/1/2015)... 2015   Regulus Therapeutics Inc . ( ... discovery and development of innovative medicines targeting microRNAs, ... Ph.D. has resigned as President and Chief Executive ... of Directors, effective today, to pursue investment opportunities ... previously served as Chief Medical Officer of Regulus, ...
(Date:6/1/2015)... Pharmaceuticals, Inc. (Nasdaq: MACK ) today announced data for ... a Phase 1 investigator-sponsored study at the University of ... at the 2015 American Society of Clinical Oncology (ASCO) ... Results from this study show a tolerable safety profile ... intravenously.  Based in part on the data ...
Breaking Medicine Technology:Lee Tran & Liang LLP Files Co-Founder Lawsuit against Leading Biotech Start-up Resilience 2Regulus' Kleanthis G. Xanthopoulos, Ph.D., to Step Down as President and Chief Executive Officer 2Regulus' Kleanthis G. Xanthopoulos, Ph.D., to Step Down as President and Chief Executive Officer 3Regulus' Kleanthis G. Xanthopoulos, Ph.D., to Step Down as President and Chief Executive Officer 4Merrimack Pharmaceuticals Announces Data from an Investigator-Sponsored Phase 1 Study Showing Acceptable Safety Profile for MM-398 in High-Grade Glioma 2Merrimack Pharmaceuticals Announces Data from an Investigator-Sponsored Phase 1 Study Showing Acceptable Safety Profile for MM-398 in High-Grade Glioma 3Merrimack Pharmaceuticals Announces Data from an Investigator-Sponsored Phase 1 Study Showing Acceptable Safety Profile for MM-398 in High-Grade Glioma 4Merrimack Pharmaceuticals Announces Data from an Investigator-Sponsored Phase 1 Study Showing Acceptable Safety Profile for MM-398 in High-Grade Glioma 5
... DALLAS, Oct. 15 /PRNewswire-FirstCall/ -- ACCESS ... provided an update on its European commercial launch of ... debilitating side effect of radiation treatment and chemotherapy. ... five European countries, having been granted the CE mak ...
... Pharmaceuticals, Inc. announced today that new data confirm that ... of fat absorption in children aged 7-11 years who ... (CF). EPI is a condition resulting from a deficiency ... are necessary to digest nutrients in food. CREON® has ...
Cached Medicine Technology:Access Pharmaceuticals Provides Update on MuGard Commercial Launch and First European Clinicians Feedback 2Access Pharmaceuticals Provides Update on MuGard Commercial Launch and First European Clinicians Feedback 3Access Pharmaceuticals Provides Update on MuGard Commercial Launch and First European Clinicians Feedback 4CREON(R) (pancrelipase) Delayed-Release Capsules Improves Absorption of Fat in Young Children With Cystic Fibrosis 2CREON(R) (pancrelipase) Delayed-Release Capsules Improves Absorption of Fat in Young Children With Cystic Fibrosis 3CREON(R) (pancrelipase) Delayed-Release Capsules Improves Absorption of Fat in Young Children With Cystic Fibrosis 4CREON(R) (pancrelipase) Delayed-Release Capsules Improves Absorption of Fat in Young Children With Cystic Fibrosis 5CREON(R) (pancrelipase) Delayed-Release Capsules Improves Absorption of Fat in Young Children With Cystic Fibrosis 6
(Date:6/1/2015)... 02, 2015 The National Association ... as a 2015-2016 inductee into its VIP Professional ... this prestigious distinction for leadership in safety, environment, health ... organization exclusively for professional women, boasting more than 700,000 ... pleased to present Lourinda with this important honor,” said ...
(Date:6/1/2015)... (PRWEB) June 02, 2015 The ... Lenita F. Cornett, DSL, LSSBB (C), First Sergeant A ... VIP Woman of the Year Circle. She is recognized ... NAPW is the nation's leading networking organization exclusively for ... 200 operating Local Chapters. , “I'm pleased to recognize ...
(Date:6/1/2015)... York, New York (PRWEB) June 01, 2015 ... ( http://www.testosteronelawsuithub.com/ ) has amended the Case Management ... Inc.’s AndroGel testosterone gel. The Amended Order which ... of Illinois on May 29, 2015, directs the parties ... Court by August 10, 2015 that outlines parameters and ...
(Date:6/1/2015)... D.C. (PRWEB) June 01, 2015 Linda Kincaid, ... and had an irregular heartbeat. At first she thought it ... found out it was much more than that. After going ... disease. Linda admitted she felt afraid about what might happen ... five million Americans are diagnosed with valve disease each year. ...
(Date:6/1/2015)... 2015 EBSCO Health , a ... DynaMed Plus™ , a cross-platform evidence-based clinical decision ... provides clinicians with the ideal blend of evidence and ... , DynaMed Plus is a significant enhancement over ... most frequently updated evidence-based content. DynaMed Plus content is ...
Breaking Medicine News(10 mins):Health News:National Association of Professional Women Inducts Lourinda Willey, Owner and Principal of Lourinda R. Willey LLC, Into its VIP Professional Woman of the Year Circle 2Health News:National Association of Professional Women Inducts Lenita F. Cornett, First Sergeant of the US Military, Into its VIP Professional Woman of the Year Circle 2Health News:Testosterone Lawsuit News: Federal Court Amends Order Governing AndroGel Bellwether Trial Selection 2Health News:Testosterone Lawsuit News: Federal Court Amends Order Governing AndroGel Bellwether Trial Selection 3Health News:Testosterone Lawsuit News: Federal Court Amends Order Governing AndroGel Bellwether Trial Selection 4Health News:A New Online Resource for Those Living with Heart Valve Disease 2Health News:A New Online Resource for Those Living with Heart Valve Disease 3Health News:EBSCO Health’s New DynaMed Plus™ Delivers Trusted, Evidence-Based Content to Physicians on Any Platform 2Health News:EBSCO Health’s New DynaMed Plus™ Delivers Trusted, Evidence-Based Content to Physicians on Any Platform 3Health News:EBSCO Health’s New DynaMed Plus™ Delivers Trusted, Evidence-Based Content to Physicians on Any Platform 4
... fruit flies get high cholesterol and become obese? The same ... too rich in fats. More importantly, according to two ... fruit flies use the same molecular mechanisms as humans to ... of stored fat that contributes to obesity. The findings mean ...
... , ARLINGTON, Va., Dec. 2 ... life that give us meaning, joy and peace, the LIFE ... using the popular photo-sharing Web site flickr.com. The winning photos ... Foundation,s Web site at www.lifehappens.org/wondersphotos . , Contestants ...
... Dec. 2 Aegis Health Group, the nation,s leading ... chief development officer. As a member of Aegis, executive ... the sales and marketing staff as they focus on ... and physician relationships. , To this newly created position, ...
... point to death from TB, not Addison,s, researcher says ... Pride and Prejudice and Emma ... has long been believed, says one British scholar. , Since ... many historians and other experts have believed the cause was ...
... , LONDON, Dec. 2 ... therapies to treat lifestyle disorders. In the near future, the ... therapies and novel drugs to treat such conditions and reduce ... New analysis from Frost & Sullivan ( http://www.pharma.frost.com ), ...
... ... Links Medical Products Inc., an industry leader in healthcare products for hospitals ... Irvine Spectrum. The new facility is located at 9247 Research Drive, Irvine, ... Spectrum plus an assembly and distribution operation in Indio, California. This most ...
Cached Medicine News:Health News:Latest epidemic? High cholesterol, obesity in fruit flies 2Health News:Latest epidemic? High cholesterol, obesity in fruit flies 3Health News:Wonders of Life Photo Contest Winners Announced 2Health News:Wonders of Life Photo Contest Winners Announced 3Health News:Aegis Health Group Hires Pearson Talbert as Chief Development Officer 2Health News:New Light on Jane Austen's Final Chapter 2Health News:Development of Newer Therapies to Treat Lifestyle Disorders and Reduce the Risk of Co-morbidities is Key to the Expansion of the European Lifestyle Disorders Therapeutics Market, Says Frost & Sullivan 2Health News:Development of Newer Therapies to Treat Lifestyle Disorders and Reduce the Risk of Co-morbidities is Key to the Expansion of the European Lifestyle Disorders Therapeutics Market, Says Frost & Sullivan 3Health News:Links Medical Opens New Headquarters, Prepares to Launch Medical-Grade Manuka Honey 2Health News:Links Medical Opens New Headquarters, Prepares to Launch Medical-Grade Manuka Honey 3
Ruschelit® PVC. Magill tip-nasoral. Black positioning ring. High volume/low pressure cuff. X-ray opaque line. Graduated. Single use....
Ruschelit® PVC. Siliconized. Stainless steel spiral reinforced. High volume/low pressure cuff.Connector is permanently fixed into the tube. X-ray opaque. Graduated. Single use. Sterile...
Tube for Right Bronchus - Ruschelit™ PVC. Color coded for easy identification of ports, balloons and 15mm connectors. High volume/low pressure cuffs. With Carina hook. X-ray opaque line. Gradua...
Laser resistant tubes for use with CO2 and KTP Lasers., ,Designed for airway management during laser surgery of the larynx or other areas in close proximity to the trachea....
Medicine Products: