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Karmanos Cancer Institute Research Supports Role of Inflammation to Determine Lung Cancer Risk, Particularly in African-American Women
Date:4/14/2008

is polymorphism. A nearby SNP on the IL10 gene was also associated with an increased risk of lung cancer among African-American women but a decreased risk among Caucasian women.

"These results suggest racial differences in the relationship between cytokine SNPs and risk of lung cancer, but larger studies need to be conducted in diverse populations to confirm these findings," said Dr. Schwartz.

According to Van Dyke, this type of information might be used to better predict who to screen for lung cancer for earlier disease detection and may lead to more targeted treatments.

"It is important that we identify disease markers for lung cancer," she said. "If diagnosed at a localized stage, the overall five-year survival rate is approximately 50 percent, yet when lung cancer is diagnosed a distant stage of disease, the five-year survival rate is only two percent."

Dr. Schwartz added, "Lung cancer remains the number one cancer killer among men and women in the United States. "If we can better predict who is at risk and then diagnose disease earlier, rates of survival will improve dramatically."

The study was funded by the National Cancer Institute. Other Karmanos Cancer Institute and Wayne State University investigators include Michele L. Cote, Ph. D., assistant professor of Internal Medicine; Angie S. Wenzlaff, M.P.H., research assistant, Epidemiology; Susan Land, Ph. D., principal investigator, Genomics Core; and Geoffry Prysak, M.P.H. and Gina B. Claeys, M.P.H., project managers.

About the Barbara Ann Karmanos Cancer Institute

Located in mid-town Detroit, MI, the Barbara Ann Karmanos Cancer Institute is one of 39 National Cancer Institute-designated comprehensive cancer centers in the United States. Caring for more than 6,000 new patients annually on a budget of $216 million, conducting more than 700 cancer-specific scientific investigation programs and clinical trials, the Karmanos Cancer Institute is among th
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