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Kareg Corporation Initiates Coverage on GenSpera with a Speculative Buy Recommendation
Date:7/14/2014

nd targeted indication is glioblastoma, a form of brain cancer with high unmet need. GNSZ's drug does not need to cross the brain barrier.
  • Both indications require smaller clinical studies and offer fast track to FDA approval. 
  • Phase II clinical trial in glioblastoma was initiated in Q1 2014.
  • GNSZ's patented technology platform has additional applications in other large cancer indications as well as imaging applications.
  • GenSpera's corporate strategy is to "de-risk" its products and thus harvest significant value via the development of drug compounds through Phase II clinical trials. GenSpera's strategy is to then monetize its efforts after conducting Phase II trials, through exit strategies, i.e., licensing or sale to "Big Pharma" without incurring the time, cost and risk of building a pharmaceutical marketing and sales organization. GNSZ has signed a number of NDA's with mid-size and "Big Pharmas". Drug development is increasingly being relegated to "junior companies" with "Big Pharma" willing to acquire the technology or drug after it has been de-risked. For example, in 2010, companies with Phase II assets were acquired at a mean price of $85 million with milestone payments of $55.2 million, and the potential of a double digit royalty percentage. Cougar Biotech, a former Bulletin-Board listed company was acquired by Johnson & Johnson in 2009 for $970M in cash for their prostate cancer drug (ZYTIGA™) which received FDA approval in April 2011. 
  • GenSpera has a robust global IP position, with a portfolio of filed and granted patents covering 12ADT and other derivatives of Thapsigargin, peptide "masking/targeting" sequences and their prodrug conjugates. The patents are owned by GenSpera with no royalties or milestone payments payable to any third party.
  • GenSpera has an experienced and well-seasoned management and scientific team. Craig Dionne, PhD, CEO, has ext
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  • SOURCE GenSpera, Inc.
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