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Kalidex Introduces Novel Fluoroquinolone, KPI-10, at the 52nd Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC)
Date:9/6/2012

ae, including MDR and fluoroquinolone-resistant strains.

In addition, James Ge, M.D., Ph.D., president and chief scientific officer of Kalidex will deliver an oral presentation at the Poster Summary Session on Early New Antimicrobial Agents at 1:45 p.m. PDT on Sunday, September 9. The data to be presented reflect the substantial progress made at Kalidex on KPI-10 since the company's inception approximately 18 months ago, and cover a wide range of preclinical efficacy, PK, and toxicology data, as well as initial Phase 1 clinical data.

"The profile of KPI-10, particularly its activity against MDR strains of E. coli, N. gonorrhoeae, Acinetobacter species, streptococci and MRSA, suggests that successful development of this drug candidate may offer physicians a valuable treatment option," said Dr. Ge.  "Furthermore, our development of intravenous (IV) and oral formulations of KPI-10 is intended to allow for an IV-to-oral step down option, which is very desirable in today's healthcare settings. We look forward to completing Phase 1 clinical evaluation of KPI-10, and anticipate beginning our Phase 2 program in mid-2013."

The complete list of 24 abstracts on KPI-10 to be presented at ICAAC is available on the Kalidex website at www.kalidex.com.

About KPI-10
KPI-10 is a novel fluoroquinolone development candidate with a broad spectrum of activity against both gram-positive and gram-negative pathogens, including MDR strains and isolates resistant to currently available fluoroquinolones. KPI-10 is readily distinguished from existing fluoroquinolones because of its potent in vitro activity against gram-positive and gram-negative bacteria that are resistant to the currently-available fluoroquinolones (such as ciprofloxacin, levofloxacin, and moxifloxacin).

KPI-10 is a potent inhibitor of bacterial topoisomerases and is bactericidal.  The PK profile of KPI-10
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SOURCE Kalidex Pharmaceuticals
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