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Kalidex Introduces Novel Fluoroquinolone, KPI-10, at the 52nd Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC)
Date:9/6/2012

MENLO PARK, Calif., Sept. 7, 2012 /PRNewswire/ -- Kalidex Pharmaceuticals, a privately-held anti-infective company, today announced the presentation of data on its lead development candidate KPI-10, a broad spectrum, next-generation fluoroquinolone, at the Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC) in San Francisco, September 9 through 12.

The data describe the in vitro and in vivo activity of KPI-10 against a wide range of important gram-negative and gram-positive pathogens, including multi-drug resistant (MDR) strains and isolates resistant to currently available fluoroquinolones. The company will also present initial Phase 1 study data, which showed that in healthy volunteers single ascending doses of oral KPI-10 were generally safe and well-tolerated and that the pharmacokinetic (PK) profile may support once-daily oral dosing.

"Resistance to currently available antibiotics is increasing worldwide, and new treatment options are needed," said Michael R. Dougherty, chief executive officer of Kalidex.  "Due to their broad spectrum and favorable PK profile, fluoroquinolones have long been regarded as workhorse antibiotics in the treatment of a wide range of community and hospital-acquired bacterial infections. However, the emergence of resistance is now limiting their clinical utility for treatment of certain important infections.  KPI-10 is a potent fluoroquinolone with a broad and balanced spectrum of activity, and is a very promising development candidate for treating these challenging infections."

A total of 24 posters on KPI-10 will be presented at the conference.  Of these, eleven demonstrate the potent in vitro and in vivo activity of KPI-10 against a wide variety of important contemporary gram-positive and gram-negative pathogens, such as staphylococci, Streptococcus pneumonia, Escherichia coli, Acinetobacter spp., and Neisseria gonorrhoe
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SOURCE Kalidex Pharmaceuticals
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