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Juventas Therapeutics completes enrollment of Phase II STOP-HF study of JVS-100 in patients with symptomatic heart failure
Date:10/28/2013

Ph.D., Chief Medical Officer for Juventas and Director of Research, Summa Cardiovascular Institute at Summa Health Systems. "The goal of STOP-HF is to further define the safety and clinical benefits of JVS-100 in heart failure patients who are already receiving the current standard of care."

Earlier this year, Juventas Therapeutics completed enrollment of STOP-CLI, a Phase IIa first-in-human, double-blinded, placebo-controlled, dose-escalation trial of JVS-100 for patients with Rutherford class 4 or 5 critical limb ischemia (CLI).  The 48-person trial enrolled CLI patients considered poor candidates for revascularization at four centers in the United States and two centers in India.  The primary endpoint for the trial will be safety with efficacy data collected on several key endpoints including amputation rates, Rutherford class, wound closure, and pain management.

"Completing enrollment of STOP-CLI and STOP-HF are significant milestones for the company this year," states Rahul Aras, Ph.D., President and CEO for Juventas Therapeutics.  "To date, more than 120 patients have received JVS-100 therapy and we are building a strong safety profile.  Next year is an important year for Juventas, with efficacy data results targeted from both Phase II studies and additional trials scheduled to enroll.  We are excited to transition JVS-100 into late stage clinical trials and commercialization."

About Juventas Therapeutics

Juventas Therapeutics, headquartered in Cleveland, Ohio, is a privately-held clinical-stage biotechnology company developing therapies for cardiovascular disease. Founded in 2007 with an exclusive license from the Cleveland Clinic, Juventas has transitioned its therapeutic platform from concept to mid-stage clinical trials for treatment of heart failure and critical limb ischemia.  Investors include New Science Ventures, Triathlon Medical Ventu
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SOURCE Juventas Therapeutics
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