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JumpStart Ventures and Cleveland Clinic Invest in SironRX Therapeutics
Date:2/7/2011

CLEVELAND, Feb. 8, 2011 /PRNewswire/ -- JumpStart Ventures, the non-profit that invests in and partners with innovative, early-stage companies in Northeast Ohio, and Cleveland Clinic, announced a combined investment commitment of $500,000 in SironRX Therapeutics, Inc. The Cleveland-based company is developing a topical therapy to enhance healing of and decrease scar formation in wounds.

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SironRX's lead drug, JVS-100, contains an engineered version of a naturally occurring molecular factor called Stromal cell-Derived Factor-1 (SDF-1) that promotes tissue repair. Although it occurs naturally in the body, the period of time the body produces SDF-1 following injury is relatively brief. When applied at the site of a surface wound, the drug sustains SDF-1's healing properties for a longer period, reducing healing time, scarring, and possible complications.

SironRX is a spinoff of the privately-held biotechnology company Juventas Therapeutics, which licensed the drug's intellectual property from Cleveland Clinic in 2007. Juventas has been developing JVS-100 for use in cardiovascular applications and recently completed enrollment of a 17-person Phase I heart failure study. The drug has been well tolerated by all patients to date, with complete safety and efficacy results available in Q2 2011. The company has also received authorization from the Food & Drug Administration to initiate a Phase II clinical trial to evaluate the safety and efficacy for use of JVS-100 to treat patients with critical limb ischemia. During pre-clinical studies, the company discovered that a topical version of JVS-100 had potential to accelerate repair and reduce scar formation in full-thickness dermal wounds.

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SOURCE JumpStart, Inc.
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