Navigation Links
Journal of Clinical Oncology Publishes Phase 2 Clinical Trial Results of KRX-0401 (Perifosine) Plus Capecitabine in Patients with Metastatic Colorectal Cancer
Date:10/5/2011

NEW YORK, Oct. 5, 2011 /PRNewswire/ -- Keryx Biopharmaceuticals, Inc. (Nasdaq: KERX) (the "Company") today announced that a manuscript entitled "Randomized Placebo-Controlled Phase II Trial of Perifosine Plus Capecitabine as Second- or Third-Line Therapy in Patients with Metastatic Colorectal Cancer" reporting Phase 2 activity of KRX-0401 (perifosine) in the treatment of patients with refractory, advanced colorectal cancer (mCRC), was selected for publication in the October 3, 2011 online edition of the Journal of Clinical Oncology (JCO).  Perifosine, the Company's novel, potentially first-in-class, oral anti-cancer drug candidate that inhibits Akt activation in the phosphoinositide 3-kinase (PI3K) pathway, is currently being investigated in a Phase 3 trial entitled the "X-PECT" (Xeloda® + Perifosine Evaluation in Colorectal cancer Treatment),which is a randomized (1:1), double-blind trial comparing the efficacy and safety of perifosine + capecitabine vs. placebo + capecitabine. The Phase 3 X-PECT study is being conducted under a Special Protocol Assessment (SPA), and with Fast Track designation.  In July, the Company announced the completion of enrollment into the Phase 3 X-PECT study, with approximately 465 patients in the United States randomized. Approximately 360 events of death will trigger the un-blinding of the study.  Study completion is expected in 1Q 2012.

The JCO publication highlights the efficacy and safety data on the 38 mCRC patients participating in this Phase 2, randomized, multicenter study, comparing perifosine plus capecitabine (P-CAP) to placebo plus capecitabine.  Based on the data, in which the combination of P-CAP demonstrated statistical significance with respect to median overall survival and median time to tumor progression, the investigators concluded that the P-CAP combination showed promising clinical activity co
'/>"/>

SOURCE Keryx Biopharmaceuticals, Inc.
Copyright©2010 PR Newswire.
All rights reserved

Page: 1 2 3 4

Related medicine technology :

1. Atrium Announces the Publication of the COBEST Trial by the Journal of Vascular Surgery
2. Telik Announces Publication in the Journal Cancer of a Phase 2 Randomized Multicenter Study of Two Extended Dosing Schedules of Oral Ezatiostat in Low to Intermediate-1 Risk Myelodysplastic Syndrome
3. eCardio Among Honorees of the Houston Business Journals Fast 100 List for Second Consecutive Year
4. Elsevier Launches European Journal of Cancer iPad Edition
5. Results of a Pivotal Phase 3 Efficacy and Safety Study for ButransĀ® (Buprenorphine) Transdermal System CIII Published in The Journal of Pain
6. NxStage: NIH Study Published in New England Journal of Medicine Adds to Growing Body of Evidence in Support of More Frequent Hemodialysis
7. New Study Published in New England Journal of Medicine Shows Investigational BIBF 1120 Demonstrated Positive Trend in Reducing Lung Function Loss in Idiopathic Pulmonary Fibrosis
8. Zertaneā„¢ Clinical Results Published in the Journal European Urology
9. Lexicon Announces Publication of Results From the Phase 2 Trial of LX1031 in Patients With Irritable Bowel Syndrome in Journal of Gastroenterology
10. Cornerstone Pharmaceuticals Announces The Journal of Molecular Medicines Publication of Research Showing Selective Inhibition of Cancer Cell Energy Metabolism With Its Novel Lipoate Derivative Compounds
11. Study Published in Journal of Vascular Surgery Confirms Superiority of Artegraft BCA to Cuffed ePTFE for Hemodialysis Access
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/25/2014)... 25, 2014 /PRNewswire-iReach/ -- Dr. Michael Gabriel of ... reacts to a recent study, which shows how grief in ... http://photos.prnewswire.com/prnh/20140723/129709 According to US ... are more likely than others to grow up overweight or ... There were two specific types of stress that caused ...
(Date:7/24/2014)...  PTC Therapeutics, Inc. (NASDAQ: PTCT ) ... conference call to report its second quarter 2014 financial ... and outlook on Thursday, August 7, 2014 at 8:30 ... The call can be accessed by dialing ... prior to the start of the call and providing ...
(Date:7/24/2014)... , Germany , and ... -- , Exclusive global license ... for SF3B1 mutations, including next-generation sequencing (NGS) gene panels, ... to be targeted by new test, indicate favorable prognosis ... syndromes  QIAGEN sees potential for developing companion ...
Breaking Medicine Technology:Dr. Michael Gabriel of GPM Pediatrics, a Noted Staten Island Pediatrics Clinic, Comments on Study, Which Names Grief as a Cause of Obesity in Children 2QIAGEN Adds Promising Genomic Biomarkers for Assessing Prognosis in Treatment of Blood Cancers to Personalized Healthcare Pipeline 2QIAGEN Adds Promising Genomic Biomarkers for Assessing Prognosis in Treatment of Blood Cancers to Personalized Healthcare Pipeline 3QIAGEN Adds Promising Genomic Biomarkers for Assessing Prognosis in Treatment of Blood Cancers to Personalized Healthcare Pipeline 4QIAGEN Adds Promising Genomic Biomarkers for Assessing Prognosis in Treatment of Blood Cancers to Personalized Healthcare Pipeline 5
... Dec. 5, 2010 Pfizer Inc. (NYSE: ... has elected Ian C. Read, 57, currently head of ... Officer and Director. Mr. Read succeeds Jeffrey B. Kindler, ... (Logo: http://photos.prnewswire.com/prnh/20100416/PFIZERLOGO) The Board,s Lead Independent Director, ...
... The Infectious Disease Research Institute (IDRI) has ... Advance Research and Development Authority (BARDA). IDRI,s work will ... to $8.5 million over three years when further development ... agency. "BARDA is supporting an important ...
Cached Medicine Technology:Pfizer Board of Directors Names Ian C. Read President and Chief Executive Officer 2Pfizer Board of Directors Names Ian C. Read President and Chief Executive Officer 3Pfizer Board of Directors Names Ian C. Read President and Chief Executive Officer 4IDRI Awarded Contract from BARDA to Develop Next Generation Adjuvants for Pandemic Influenza 2
(Date:7/25/2014)... 25, 2014 This is a ... of the Galactooligosaccharides (GOS) industry in Global ... of the industry, including definitions, applications and industry ... market analysis are provided with a focus on ... market. A comparison between the international and Chinese ...
(Date:7/25/2014)... 25, 2014 Drexel University College of ... MD, MS, FACP, has been appointed vice dean for education, ... Drexel from The Commonwealth Medical College, where she is currently ... clinical affairs, and professor of medicine. , As a ... College, Weber had a major role in many aspects of ...
(Date:7/25/2014)... News) -- Shift workers, especially men, may be at higher ... such schedules, a new study suggests. Also at special ... schedule, with shifts moving around at various times of the ... one expert, Dr. Alan Manevitz, a clinical psychiatrist at Lenox ... known that working shifts disrupts many key body chemicals, creating ...
(Date:7/25/2014)... FRIDAY, July 25, 2014 (HealthDay --, Treatment for lymphoma ... Hodgkin lymphoma and non-Hodgkin lymphoma, which are cancers of ... who are still in their reproductive years. For men, ... production. Although most men regain their fertility within two ... be counseled about the possibility of this significant side ...
(Date:7/25/2014)... new system that sent patients to designated cardiac receiving ... sudden cardiac arrest in Arizona, according to a study ... Medicine . , "We knew lives would be ... guidelines for post-cardiac arrest care and we were able ... to what is done for Level 1 trauma patients," ...
Breaking Medicine News(10 mins):Health News:GOS Market (Galacto-oligosaccharides) Development in Global & China Regions Now Available at DeepResearchReports.com 2Health News:GOS Market (Galacto-oligosaccharides) Development in Global & China Regions Now Available at DeepResearchReports.com 3Health News:Valerie D. Weber, MD, Appointed Vice Dean for Education at Drexel University College of Medicine 2Health News:Valerie D. Weber, MD, Appointed Vice Dean for Education at Drexel University College of Medicine 3Health News:Study Links Shift Work to Risk for Type 2 Diabetes 2Health News:Study Links Shift Work to Risk for Type 2 Diabetes 3Health News:Lymphoma Treatment May Harm, Halt Men's Sperm Production 2Health News:New EMS system in Arizona dramatically improves survival from cardiac arrest 2Health News:New EMS system in Arizona dramatically improves survival from cardiac arrest 3
... A Georgetown University Medical Center (GUMC) scientist who ... frogs and in the dogfish shark has now turned ... dolphins. A dolphin,s ability to heal quickly from ... to infection, hemorrhage protection, and near-restoration of normal body ...
... and Society of Breast Imaging applaud and support updated ... women begin getting annual mammograms at age 40. The ... American Cancer Society, ACR, Society of Breast Imaging (SBI), ... major medical associations with demonstrated expertise in breast cancer ...
... Reporter , WEDNESDAY, July 20 (HealthDay News) -- High-tech helmets ... the force of impact, offering new insight into head and ... help manufacturers design helmets that are more protective, said Steven ... Michigan and lead author of a new report about the ...
... test to distinguish harmless from precancerous pancreatic cysts. ... surgery to remove the harmless variety. A report ... issue of Science Translational Medicine . The ... than a million patients each year, most of whom ...
... News) --, Liars can control certain facial expressions when facing ... a new study shows. The researchers noted the findings ... the study, scientists randomly asked 60 people to either lie ... of movie tickets from an envelope. While being interviewed, the ...
... researchers have developed a new strategy to improve the development ... are created by introducing four defined genes to an adult ... cell, which can differentiate into many different types of the ... Oct4, Sox2, Klf4 and c-Myc, a combination known as OSKM. ...
Cached Medicine News:Health News:Dolphins' 'remarkable' recovery from injury offers important insights for human healing 2Health News:Dolphins' 'remarkable' recovery from injury offers important insights for human healing 3Health News:ACR, SBI support updated ACOG recommendations that women begin annual mammograms at age 40 2Health News:High-Tech Football Helmets Gauge Force of Collision 2Health News:Benign or cancerous? Gene test predicts cancer potential in pancreatic cysts 2Health News:Benign or cancerous? Gene test predicts cancer potential in pancreatic cysts 3Health News:Scrutinizing Faces Might Catch Liars, Study Finds 2Health News:U of M researchers improve method to create induced pluripotent stem cells 2
... an automatic petri dish streaking machine. ... up to 180 pre inoculated petri ... in substantial cost savings. The ISOPLATER® ... standardizes streaking procedures and increases safety ...
Data review and analysis is carried out with the Acquidata Uromac software already supplied with Acquidata Uromac Lab based urodynamics systems...
A compact mobile System Cart gives mobility within your department. The cart accomodates the Uromac Median data processor, desktop computer, printer and provides stowage space. Patient related transd...
... for any clinical setting, offering an ... UDS procedure. Customize Delphis™ to your ... a Pocket PC, a Touchpad PC ... wireless technology allows you to focus ...
Medicine Products: