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Journal of Antimicrobial Chemotherapy Paper Supports Additional Role for Cethromycin as Potential Treatment for Infections Caused by Community- Associated Methicillin Resistant Staphylococcus Aureus (CA-MRSA)
Date:6/25/2008

ity. Six isolates proved resistant to both erythromycin and clindamycin, against which cethromycin MIC and MBC ranges were < / = 0.002-0.06 mg/L.

David A. Eiznhamer, Ph.D., Executive Vice President of Clinical Development at Advanced Life Sciences, a co-author of the paper noted, "The susceptibility of CA-MRSA to cethromycin is especially important, as most of the isolates in this study were resistant to one or more macrolides. The growing resistance of pathogens to macrolide-based treatments is increasing the demand for new antibiotics that can overcome this resistance. We believe this study demonstrates that cethromycin could prove very beneficial in the treatment of respiratory tract infections, including those caused by pathogens such as CA-MRSA."

About Staphylococcus aureus (MRSA)

Methicillin-resistant Staphylococcus aureus (MRSA) is a type of bacteria that is resistant to certain antibiotics. Staph infections, including MRSA, occur most frequently among persons in hospitals and healthcare facilities, such as nursing homes and dialysis centers, who have weakened immune systems. MRSA infections that occur in otherwise healthy people who have not been recently hospitalized or who have undergone a medical procedure such as dialysis or surgery, are known as community-associated (CA-MRSA) infections. These infections are usually skin infections, such as abscesses, and boils but CA-MRSA can also cause respiratory infections such as community acquired pneumonia.

Macrolides and clindamycin are currently the front-line treatments for respiratory tract infections. As macrolide and clindamycin resistance to current pathogens grows and has the potential to cause more clinical failures, there is a need for new antibiotics with unique mechanisms of action that can overcome this emerging resistance.

About Cethromycin

Cethromycin has shown higher in vitro potency and a broader range of activity than macrolides against Gram-positive bac
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SOURCE Advanced Life Sciences Holdings, Inc.
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