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Journal of Antimicrobial Chemotherapy Paper Supports Additional Role for Cethromycin as Potential Treatment for Infections Caused by Community- Associated Methicillin Resistant Staphylococcus Aureus (CA-MRSA)
Date:6/25/2008

SA), and has rapidly become one of the most common causes of skin and soft tissue infections among otherwise healthy people in the community. Staphylococcus aureus and CA-MRSA are causative pathogens for respiratory tract infections such as community acquired pneumonia (CAP). The CA-MRSA strain can attack and destroy white blood cells that normally help fight infections and can be even more aggressive than the hospital associated MRSA infections. Although the early strains of CA-MRSA strains were susceptible to most antimicrobials, bacterial resistance has increased, creating a need for new antibiotics that can cover the emerging deadly CA-MRSA strain.

The aim of the study reported in the paper was to compare the antimicrobial activity of cethromycin with three other macrolides (azithromycin, clarithromcin and erythromycin) and one lincosamide (clindamycin) against the 170 MRSA USA300 isolates that are contained in the Center for Biological Defense collection at the University of South Florida.

Cethromycin was shown to be effective against all 170 isolates, achieving an MIC range of < / = 0.002-0.125 mg/L, whereas the MIC50 and MIC90 were both < / = 0.002 mg/L. In addition, cethromycin demonstrated a MBC range of < / = 0.002-1.0 mg/L, with the MBC50 of < / = 0.002 mg/L and the MBC90 of < / = 0.008 mg/L. Of the 170 CA-MRSA isolates, 169 (99.4%) were intermediate or resistant to at least one macrolide. In contrast, 164 (96.5%) isolates were susceptible to clindamycin. Only six (3.5%) isolates demonstrated either constitutive resistance [4 (2.4%)] or inducible resistance [2 (1.2%)] to clindamycin. Against 10 erythromycin-susceptible isolates, the cethromycin MIC and MBC ranges were < / = 0.002-0.008 mg/L, compared with the MIC range of < / = 0.002-0.25 mg/L and MBC range of < / = 0.002-1.0 mg/L obtained with the erythromycin-resistant isolates. MIC50 and MBC50 values, as well as MIC90 and MBC90 values, did not change regardless of erythromycin susceptibil
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SOURCE Advanced Life Sciences Holdings, Inc.
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