Navigation Links
Joslin Study Identifies Key Factor That Links Metabolic Syndrome; Finding May Help Millions at High Risk of Cardiovascular Disease
Date:2/5/2008

BOSTON, Feb. 5 /PRNewswire-USNewswire/ -- A new study led by researchers at Joslin Diabetes Center has identified insulin resistance in the liver as a key factor in the cause of metabolic syndrome and its associated atherosclerosis, disorders that put tens of millions of Americans at high risk of cardiovascular disease.

The findings, published in the February issue of Cell Metabolism, provide not only an understanding of how metabolic syndrome occurs, but also pinpoint a target for treatment of the condition. This represents the work of Sudha Biddinger, M.D., Ph.D., and a team led by C. Ronald Kahn, M.D., Head of the Joslin Research Section on Obesity and Hormone Action and the Mary K. Iacocca Professor of Medicine at Harvard Medical School.

"This is one of the first true insights into the role of the liver in the metabolic syndrome and provides guidance for future therapies," said senior investigator Dr. Kahn, an internationally recognized researcher in diabetes and metabolism. "Showing this connection between atherosclerosis and insulin resistance is one of the most dramatic findings I've seen in 35 years."

Metabolic syndrome is a collection of medical problems related to insulin resistance, including obesity, glucose intolerance, hypertension, lowered HDL ("good") cholesterol and elevated triglycerides. Together these are associated with an increased risk of atherosclerosis, the buildup of plaque in the coronary arteries that leads to heart attack and stroke.

"This study clearly indicates that metabolic syndrome is not merely a collection of abnormalities that should be considered and treated independently, as some experts have advocated," said Kahn and Biddinger. "Rather, it appears that metabolic syndrome is truly a group of closely linked disturbances in glucose and cholesterol metabolism that stem from a defect in insulin signaling in the liver."

The research was funded in part by grants from the National In
'/>"/>

SOURCE Joslin Diabetes Center
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2

Related medicine technology :

1. Ceremeds OSTENE(R) Stops Bone Bleeding Without Added Risk of Surgical Infection, New Study Finds
2. IDM Pharma Announces Phase 3 Mifamurtide (L-MTP-PE) Study Demonstrating Improved Survival Published in the Journal of Clinical Oncology
3. Tigris Pharmaceuticals Initiates Phase I Study of AFP-464 in Patients with Solid Tumors
4. Inverseon Announces Positive Phase IIa Asthma Study
5. Takeda Doses First Patient in a U.S. Phase 1 Study of Hematide(TM) to Treat Chemotherapy Induced Anemia
6. Study Says Allergy Shots Help Children, Reduce Health Care Costs
7. EntreMed Commences Phase 2 Study With MKC-1 in Ovarian/Endometrial Cancers
8. Mayo Clinic Study Finds Further Association Between Diabetes and Pancreatic Cancer
9. Divine Corporations Personal Lubricants Shown to Block Cancer-causing Viruses in a Study by the National Cancer Institute
10. Protalix BioTherapeutics Extends Research Agreement With Yissum Based on Promising Acetylcholinesterase Program Results in Animal Study
11. Northwestern Memorial Transplant Program Initiates New Study
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/20/2014)... , August 20, 2014 ... report titled "Monochloroacetic Acid (MCA) Market for Cellulosics, Agrochemicals, ... Industry Analysis, Size, Share, Growth, Trends and Forecast 2014 ... at USD 817.1 million in 2013 and is anticipated ... a CAGR of 3.6% during the forecast period from ...
(Date:8/20/2014)... Reportlinker.com announces that a new market ... Global Coatings for Medical Devices Industry ... This report analyzes the worldwide markets for Coatings ... following Product Segments: Active Coatings, Protective Coatings, Optical ... comprehensive analytics for the US, Canada ...
(Date:8/20/2014)... Aug. 20, 2014 Reportlinker.com announces that a ... Global Feminine Hygiene Products Industry ... the worldwide markets for Feminine Hygiene Products in US$ ... Panty liners, and Others. The report provides separate comprehensive ... Japan , Europe ...
Breaking Medicine Technology:Global Monochloroacetic Acid (MCA) Market is Expected to Reach USD 1,046.7 million by 2020: Transparency Market Research 2Global Monochloroacetic Acid (MCA) Market is Expected to Reach USD 1,046.7 million by 2020: Transparency Market Research 3Global Monochloroacetic Acid (MCA) Market is Expected to Reach USD 1,046.7 million by 2020: Transparency Market Research 4Global Coatings for Medical Devices Industry 2Global Coatings for Medical Devices Industry 3Global Coatings for Medical Devices Industry 4Global Coatings for Medical Devices Industry 5Global Coatings for Medical Devices Industry 6Global Coatings for Medical Devices Industry 7Global Coatings for Medical Devices Industry 8Global Coatings for Medical Devices Industry 9Global Coatings for Medical Devices Industry 10Global Coatings for Medical Devices Industry 11Global Coatings for Medical Devices Industry 12Global Coatings for Medical Devices Industry 13Global Coatings for Medical Devices Industry 14Global Coatings for Medical Devices Industry 15Global Coatings for Medical Devices Industry 16Global Coatings for Medical Devices Industry 17Global Coatings for Medical Devices Industry 18Global Coatings for Medical Devices Industry 19Global Coatings for Medical Devices Industry 20Global Coatings for Medical Devices Industry 21Global Feminine Hygiene Products Industry 2Global Feminine Hygiene Products Industry 3Global Feminine Hygiene Products Industry 4Global Feminine Hygiene Products Industry 5Global Feminine Hygiene Products Industry 6Global Feminine Hygiene Products Industry 7Global Feminine Hygiene Products Industry 8Global Feminine Hygiene Products Industry 9Global Feminine Hygiene Products Industry 10Global Feminine Hygiene Products Industry 11Global Feminine Hygiene Products Industry 12Global Feminine Hygiene Products Industry 13
(Date:8/20/2014)... HealthDay Reporter WEDNESDAY, Aug. 20, 2014 (HealthDay ... help doctors diagnose and treat the most aggressive melanomas, researchers ... the deadliest skin cancers occur most often on the head ... sun exposure. These lesions also grow quickly and are ... called "high mitotic rate" -- is associated with poorer ...
(Date:8/20/2014)... one of the most persistent and deadliest infectious diseases ... each year. , Scientists who study tuberculosis have long ... spread from humans in Africa to seals and sea ... transmitted it to Native people there before Europeans landed ... Reveal Seals as a Source of New World Human ...
(Date:8/20/2014)... August 20, 2014 As concerns regarding ... power morcellators ( http://www.injurybeacon.com/power-morcellator/ ) in gynecological surgery ... U.S. Senators from New York are urging the U.S. ... of the devices. In a letter dated August 19th, ... implored the agency to seriously consider the testimony given ...
(Date:8/20/2014)... that the amygdala stimulates stress responses in adults, ... University have found that the amygdala has an ... development of nonhuman primates. , The results are ... . , The amygdala is a region of ... to threatening situations and learning about threats. Alterations ...
(Date:8/20/2014)... Steven Reinberg HealthDay Reporter ... disorder that dismantles a baby,s immune system is twice as ... 3 million infants says. This is the first evaluation ... treatable condition known as severe combined immunodeficiency (SCID), or "Bubble ... of this condition by the boy in the bubble, who ...
Breaking Medicine News(10 mins):Health News:High-Risk Melanomas Often on Head or Neck, Study Finds 2Health News:High-Risk Melanomas Often on Head or Neck, Study Finds 3Health News:New research shows seals and sea lions likely spread tuberculosis to humans 2Health News:New research shows seals and sea lions likely spread tuberculosis to humans 3Health News:Power Morcellator News: Bernstein Liebhard LLP Notes Senators’ Letter Seeking FDA Morcellator Recall 2Health News:Power Morcellator News: Bernstein Liebhard LLP Notes Senators’ Letter Seeking FDA Morcellator Recall 3Health News:Power Morcellator News: Bernstein Liebhard LLP Notes Senators’ Letter Seeking FDA Morcellator Recall 4Health News:Maturing brain flips function of amygdala in regulating stress hormones 2Health News:Maturing brain flips function of amygdala in regulating stress hormones 3Health News:'Bubble Boy' Disease May Be More Common Than Thought 2Health News:'Bubble Boy' Disease May Be More Common Than Thought 3
... PROVIDENCE, R.I., Sept. 15 Walkers from across southern New ... at 11a.m. on behalf of Hasbro Children,s Hospital at the ... staff and the public are invited to team up to ... in this festive fall fundraiser. Grand Marshall Mayor David N. ...
... , , ... for Healthcare Information Technology (CCHIT(R)) today announced that gloStream,s ... Ambulatory EHR additionally certified for Cardiovascular Medicine and Child ... (EHR) criteria for office-based use. Ambulatory EHRs are designed ...
... , , WASHINGTON , Sept. 15 ... consumers to help them understand a new law requiring insurance ... Wellstone and Pete Domenici Mental Health Parity and Addiction Equity, ... 2010. The law is designed to help improve access ...
... , , ... on Lifesaving Skills , , PITTSBURGH, ... in October, the Sudden Cardiac Arrest Foundation today announced the launch ... on YouTube ( http://www.youtube.com/user/SCAFoundation ). Students from elementary school through ...
... Conn., Sept. 15 Americans have been hearing more about health ... comes to understanding their own health benefits, many may be missing ... Open Enrollment and even save money throughout the year. A survey ... benefits public education program launched in September 2004 by Aetna (NYSE: ...
... studies suggest transmission of virus may last up to a ... with swine flu seem to be contagious longer than patients ... it,s not clear what impact the findings will have on ... the virus continues to produce relatively mild infections in most ...
Cached Medicine News:Health News:Hasbro Children's Hospital Kicks Off Inaugural Fundraising Walk 2Health News:Hasbro Children's Hospital Kicks Off Inaugural Fundraising Walk 3Health News:gloStream's gloEMR Version 5.0 Receives 08 CCHIT Certification 2Health News:gloStream's gloEMR Version 5.0 Receives 08 CCHIT Certification 3Health News:APA Offers Free Resources for Public on Mental Health Parity Law 2Health News:Sudden Cardiac Arrest Foundation Kicks Off 'You Can Save A Life' Video Awareness Contest on YouTube(TM) 2Health News:Sudden Cardiac Arrest Foundation Kicks Off 'You Can Save A Life' Video Awareness Contest on YouTube(TM) 3Health News:Consumers Overlooking Opportunities at Open Enrollment May be Missing Out 2Health News:Consumers Overlooking Opportunities at Open Enrollment May be Missing Out 3Health News:Consumers Overlooking Opportunities at Open Enrollment May be Missing Out 4Health News:Consumers Overlooking Opportunities at Open Enrollment May be Missing Out 5Health News:Consumers Overlooking Opportunities at Open Enrollment May be Missing Out 6Health News:People With Swine Flu May Be Contagious Longer Than Thought 2Health News:People With Swine Flu May Be Contagious Longer Than Thought 3
Ethicon, small clip size, 10mm, rotatable take apart...
Solid phase capture sandwich ELISA assay using a microwell format....
... for the laboratory in flexibility, communication, security, ... one function to another. You can review ... a new patient record simultaneously. LabDAQ is ... all the open functions and to move ...
... Size , The ADVIA 1200 system features a ... any size laboratory. , , Standardization as Part ... system uses the same reagents, calibrators and controls as ... is based on the same proven reliability. , ...
Medicine Products: