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Johns Hopkins University Researchers to Clinically Assess Rosetta Genomics' miRview(TM) Squamous Assay
Date:10/2/2008

rrhage among NSCLC patients with predominantly squamous histology. This has led patients with squamous-cell histology to be regarded by many as inappropriate candidates for therapy with this drug. In addition, several other targeted drugs for NSCLC currently under development may require this type of accurate differentiation due to different side effect profiles or different levels of efficacy.

Combining Rosetta Genomics' proprietary microRNA extraction technology from FFPE samples, sensitive quantification platforms, and microRNA molecular biomarkers identified by the company, Rosetta Genomics has developed a test which differentiates squamous cell carcinoma of the lung from non-squamous NSCLC. This test, which is the subject of the study to be conducted at John Hopkins, is in the final stages of development and is expected to be commercially available by the fourth quarter of 2008.

In July, Columbia University Medical Center's (CUMC) High Complexity Molecular Pathology Laboratory received the approval of the New York State regulators for a test differentiating Squamous NSCLC from other NSCLC. This test, which is based on Rosetta Genomics' technology, exhibited sensitivity of 96 percent and specificity of 90 percent.

About microRNAs

MicroRNAs (miRNAs) are recently discovered, naturally occurring, small RNAs that act as master regulators and have the potential to form the basis for a new class of diagnostics and therapeutics. Since many diseases are caused by the abnormal activity of proteins, the ability to selectively regulate protein activity through microRNAs could provide the means to treat a wide range of human diseases. In addition, microRNAs have been shown to have different expression in various pathological conditions. As a result, these differences may provide for a novel diagnostic strategy for many diseases.

About Johns Hopkins University

Founded in 1876, the Johns Hopkins University was the first research unive
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SOURCE Rosetta Genomics Ltd
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