Navigation Links
Jennerex and Transgene Announce Initiation of Clinical Trial of Intravenous JX-594 in Patients With Refractory Metastatic Colorectal Cancer
Date:12/16/2010

SAN FRANCISCO and ILLKIRCH, France, Dec. 16, 2010 /PRNewswire/ -- Jennerex, Inc., a private clinical-stage biotherapeutics company focused on the development and commercialization of first-in-class targeted oncolytic products for cancer, and Transgene (NYSE Euronext Paris: FR0005175080), a bio-pharmaceutical company specialized in the development of immunotherapeutic products, today announced that enrollment and treatment of patients in a Phase 1b clinical trial has been initiated to evaluate JX-594 in patients with advanced metastatic, refractory colorectal cancer (CRC).  The study will be performed in Korea, where Green Cross Corporation holds market rights for JX-594.

"The initiation of this study marks an important step forward in the development of JX-594 for a second major oncology indication. With a significant and growing population of colorectal cancer patients who have failed existing therapies or for whom existing therapies are not appropriate, we believe JX-594, with its unique mechanisms of action and demonstrated tumor response in preclinical models of CRC, may provide an important new therapeutic modality for patients around the world suffering from this devastating cancer," said David H. Kirn, M.D., president and chief executive officer of Jennerex.

"The study design for this trial builds on our joint experience and positive clinical results using JX-594 to treat liver cancer and represents an important milestone which is our ability to administer multiple doses intravenously," added Philippe Archinard, chairman and chief executive officer of Transgene.

The intravenous, open-label, multi-dose-escalation study is being conducted at Samsung Cancer Center in Seoul, South Korea. The study will enroll up to 15 patients with metastatic colorectal cancer that have failed both oxaliplatin-based and irinotecan-based chemotherapy regimens, and whose tumors harbor ras mutations and/ or are refractory to Erbitux therapy. Patients en
'/>"/>

SOURCE Jennerex, Inc.
Copyright©2010 PR Newswire.
All rights reserved

Page: 1 2 3 4 5

Related medicine technology :

1. Jennerex Names Dr. Mark P. Backer as Senior Vice President of Technical Operations
2. Jennerex Appoints Lara Longpre to Chief Operating Officer
3. Jennerex Appoints Gregory W. Schafer as Chief Financial Officer
4. Jennerex Announces Presentations at Upcoming Conferences
5. Jennerex, Inc. Receives EMEA Orphan Drug Designation for JX-594 for the Treatment of Hepatocellular Carcinoma
6. Jennerex Therapeutic Research Collaboration With Ottawa Hospital Research Institute Selected for $10 Million Grant From Ontario Institute for Cancer Research
7. Jennerex Treats First Patients in Phase 2 JX-594 Trial for Liver Cancer
8. Jennerex Completes the Treatment of First Patient Cohort in Phase 1 Trial With Intravenous Delivery of JX-594 Oncolytic Virus
9. Jennerex Publishes Clinical Trial Data With Lead Product JX-594 Demonstrating Efficacy Against Liver Cancer and Associated Hepatitis B Virus
10. Jennerex Publishes Promising Results from Cancer Clinical Trial of JX-594 in Lancet Oncology
11. Jennerex Presents Clinical Data From JX-594 Demonstrating Tumor Efficacy Against Advanced Liver Cancers
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/27/2014)... YORK , Aug. 27, 2014 ... is available in its catalogue: Global ... http://www.reportlinker.com/p02316641/Global-Animal-Health-Market-2014-2018.html About Animal Health Animal ... animal diseases or treat animals to enhance their ... the yield of animal food. The Global Animal ...
(Date:8/27/2014)... , Aug. 27, 2014 ... research report is available in its ... for Application and Approval of Imported ... Practices (2014 Edition) ... Now, Chinese regulations on medical ...
(Date:8/27/2014)... , Aug. 27, 2014 Amgen (NASDAQ: ... and Drug Administration (FDA) has granted priority review designation ... (HF). Ivabradine is an oral drug that inhibits the ... the sinoatrial node, the body,s cardiac pacemaker. 1 ... effects on myocardial contractility or ventricular repolarization. 1 ...
Breaking Medicine Technology:Global Animal Health Market 2014-2018 2Global Animal Health Market 2014-2018 3Global Animal Health Market 2014-2018 4Global Animal Health Market 2014-2018 5Global Animal Health Market 2014-2018 6Global Animal Health Market 2014-2018 7Latest Chinese Guidebook for Application and Approval of Imported Medical Device Registration: From Regulations to Practices (2014 Edition) 2Latest Chinese Guidebook for Application and Approval of Imported Medical Device Registration: From Regulations to Practices (2014 Edition) 3Latest Chinese Guidebook for Application and Approval of Imported Medical Device Registration: From Regulations to Practices (2014 Edition) 4Latest Chinese Guidebook for Application and Approval of Imported Medical Device Registration: From Regulations to Practices (2014 Edition) 5Latest Chinese Guidebook for Application and Approval of Imported Medical Device Registration: From Regulations to Practices (2014 Edition) 6Latest Chinese Guidebook for Application and Approval of Imported Medical Device Registration: From Regulations to Practices (2014 Edition) 7Latest Chinese Guidebook for Application and Approval of Imported Medical Device Registration: From Regulations to Practices (2014 Edition) 8Latest Chinese Guidebook for Application and Approval of Imported Medical Device Registration: From Regulations to Practices (2014 Edition) 9Latest Chinese Guidebook for Application and Approval of Imported Medical Device Registration: From Regulations to Practices (2014 Edition) 10FDA Grants Amgen Priority Review Designation For Ivabradine For The Treatment Of Chronic Heart Failure 2FDA Grants Amgen Priority Review Designation For Ivabradine For The Treatment Of Chronic Heart Failure 3FDA Grants Amgen Priority Review Designation For Ivabradine For The Treatment Of Chronic Heart Failure 4FDA Grants Amgen Priority Review Designation For Ivabradine For The Treatment Of Chronic Heart Failure 5FDA Grants Amgen Priority Review Designation For Ivabradine For The Treatment Of Chronic Heart Failure 6FDA Grants Amgen Priority Review Designation For Ivabradine For The Treatment Of Chronic Heart Failure 7
... 16, 2012  Palatin Technologies, Inc. (NYSE Amex: ... receptor-specific peptide therapeutics for the treatment of diseases ... today announced that Dr. Carl Spana, President and ... Financial Capital Markets, Eighth Annual Equity Conference.  The ...
... Reportlinker.com announces that a new market ... , Pharmaceutical M&A in the ... Introduction ... markets, prompted by generic erosion of branded ...
Cached Medicine Technology:Palatin Technologies to Present at BOCEMb, Noble Financial Capital Markets' Eighth Annual Equity Conference 2Pharmaceutical M&A in the Asia Pacific Region 2Pharmaceutical M&A in the Asia Pacific Region 3Pharmaceutical M&A in the Asia Pacific Region 4
(Date:8/28/2014)... Now in its 4th year, Step for Hope ... two brain aneurysm survivors. The ongoing mission of Step for ... help increase early detection and to help support individuals and ... hope that you will be able to join this remarkable ... Step for Hope Run/ Walk on Saturday, September 6, 2014. ...
(Date:8/28/2014)... FL (PRWEB) August 28, 2014 The ... that produces deep, resonant, meditative sounds that can be ... talent is needed to use it – just taking ... always sounds soothing. , Here are some examples ... ,     Close your eyes, relax, and maintain good ...
(Date:8/28/2014)... 2014 On September 1st, the National ... campaign. The goal is to help families and ... and effectively and without exposures to risky pesticides. ... “Children’s exposures to pesticides should be limited as ... Head lice are often trivialized in the media, which ...
(Date:8/27/2014)... 2014 Author and orthopedic surgeon William ... on the thrilling adventures of sharp and witty ... is gearing up for a new marketing push in ... novellas , “Prescription: Murder” follows the adventures of ... dodging assassination attempts and thwarting criminals. In the first ...
(Date:8/27/2014)... Spine Guide has built a reputation for itself ... health. Now, the e-health site will offer new surgical ... pain symptoms. Spine Guide specializes in three types of ... surgery. , Some of the most common back pain ... radiating down the leg, inability to stand up straight, ...
Breaking Medicine News(10 mins):Health News:Step for Hope and Raise Brain Aneurysm Awareness 2Health News:Ever Thought of Meditating With a Harmonica; Harmonica Techs, Inventors of the Pulmonica® Pulmonary Harmonica®, Present Tips on How to Relax with Soothing Sounds 2Health News:Head Lice Can Be a Public Health Opportunity 2Health News:Head Lice Can Be a Public Health Opportunity 3Health News:Head Lice Can Be a Public Health Opportunity 4Health News:William H. Simon Launches New Marketing Campaign for Book 2Health News:Spine Guide Offering New Overview of Surgical Options For Back Pain 2
... ruling Left Democratic Front (LDF) urging Chief Minister V.S. Achuthanandan ... the state// , the humble tender coconut may finally get ... available in plenty in the state, sales have been low. ... soft drinks from Pepsi and Coca-Cola creating a furore again, ...
... research conducted by de las Fuentes and colleagues at Washington ... hearts with muscle thickening// or hypertrophy due to high blood ... Their finding has been published in the recent issue ... the single most energy-consuming organ per weight in the body," ...
... years, researchers have struggled to understand how IVIG worked. ... an apparent contradiction.// ,Intravenous immunoglobulin (IVIG) ... human plasma that contains the pooled antibodies from thousands ... few assorted conditions; nonetheless, practitioners have used it off-label ...
... David Schutt of Thomson Medstat, a Michigan-based health-care research firm ... are obese think their eating habits are healthy. ... said that they did vigorous exercise for times a week. ... two or more times a day. In conclusion Dr. David ...
... study in Britain has found that nearly one-third of people ... due to rupture, or simply slipping off// during sex, which ... world undertook a survey of nearly 497 people for the ... 64% were groping in the dark about the reasons for ...
... the US U.S. doctors often misdiagnose tuberculosis due to ... suffer for years.// ,Tuberculosis is among the ... to the World Health Organization, has taken the lives ... tuberculosis bacterium has the ability to remain dormant for ...
Cached Medicine News:Health News:Fat Metabolism Of Heart Muscles Affected By High Blood Pressure 2Health News:Fat Metabolism Of Heart Muscles Affected By High Blood Pressure 3Health News:Single Sugar Enables Antibody to Treat Inflammation 2Health News:Single Sugar Enables Antibody to Treat Inflammation 3Health News:Doctors In US Lack Skills For The Diagnosis Of TB 2
... The Instacup Multi-Drug Screen Panel is used for ... human urine. The Instacup Panel consists of a test ... the test card is inserted and the sample sealed ... It is not necessary to remove the test card ...
The Osteomark NTx Point of Care (POC)device allows physicians to monitor their patients response to anti-resorptive drugs as early as 3-6 months from starting treatment. Osteomark NTx shows you and y...
... useful measurement for distinguishing between anemic, ... the preferred diagnostic method for monitoring ... experienced changes in plasma volume including ... also used to measure the effects ...
... enables the fast and exact determination of ... handy photometer and micro-cuvettes, filled with dry ... or arterial blood should be taken with ... so filled cuvette can now be inserted ...
Medicine Products: