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Jennerex Treats First Patients in Phase 2 JX-594 Trial for Liver Cancer
Date:1/12/2009

30 total patients will be treated.

New Alliance for Use of Quadra-Fuse, Multi-pronged Injection Needles

Jennerex also announced today an alliance with Rex Medical, a manufacturer of advanced multi-pronged needles, for the targeted intratumoral administration of JX-594. Jennerex shall exclusively use Rex Medical Quadra-Fuse needles ("QF Needles") for intratumoral injections of JX-594 in clinical development, and Rex Medical shall work collaboratively with Jennerex to effectively apply this technology to JX-594 clinical development.

"We are excited to be collaborating with Rex Medical, the market leader in this field, for application of Quadra-Fuse needle technology with JX-594. This is the first needle designed for optimizing therapeutic delivery of fluids/agents into target tissue zones. This innovative multi-pronged design allows us to precisely target distribution of JX-594 for optimal therapeutic effect. The result is an innovative and potentially landmark combination of a highly targeted biotherapeutic agent with a sophisticated medical device for targeted delivery," stated Dr. Kirn.

About JX-594

JX-594 is a cancer biotherapeutic product, currently in Phase 2 trials, from a proprietary breakthrough class of targeted and armed oncolytic poxviruses. Tumor destruction and safety was shown in patients with diverse cancer types on three Phase 1 trials; treated patients were end-stage and had no effective therapies available. JX-594 multiplies selectively within cancer cells, leading to their destruction. These newly created copies of JX-594 are then released and are able to infect and eradicate other tumor cells both locally and in distant sites in the body. This cycle of JX-594 replication, cancer cell destruction, release and spread is then repeated. Normal cells are not affected by JX-594 resulting in safety and tolerability. The poxvirus strain backbone of JX-594 has
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SOURCE Jennerex, Inc.
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3. Jennerex Publishes Promising Results from Cancer Clinical Trial of JX-594 in Lancet Oncology
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