Navigation Links
Jennerex Publishes Clinical Trial Data With Lead Product JX-594 Demonstrating Efficacy Against Liver Cancer and Associated Hepatitis B Virus
Date:7/22/2008

Study Demonstrates Feasibility and Efficacy of Treating Patients with

Primary Liver Cancer

SAN FRANCISCO, and YONGIN-SI, South Korea, July 22 /PRNewswire/ -- Jennerex, Inc. (San Francisco, CA and Ottawa, Ontario), and its South Korean partner Green Cross Corp., announced today that novel findings from a Phase I clinical trial of its first-in-class lead product JX-594 demonstrated that the product was well-tolerated and resulted in clear anti-cancer efficacy in patients with liver cancer. Three patients with advanced treatment-refractory hepatitis B virus (HBV)-associated hepatocellular carcinoma (HCC) were treated with JX-594. Objective radiographic responses were demonstrated. Serum tumor markers, which correlate with tumor burden over time in patients, decreased by up to 95 percent after treatment. JX-594 replication, its release into the circulation and distant tumor targeting and infection were demonstrated. JX-594 administration resulted in tumor vascular shutdown. Oncolytic virotherapy was also shown, for the first time, to suppress underlying HBV replication in HCC patients by over 50 percent in all three patients. A Phase II clinical trial is now underway for JX-594 in liver cancer. The data were published in the journal Molecular Therapy.

"These clinical results with JX-594 in end-stage liver cancer patients represent a major step forward for JX-594 against this difficult to treat cancer. We are excited by the potential to fulfill the huge unmet medical needs for these desperate patients with no curative treatment options, specifically by treating their tumors and potentially their underlying Hepatitis B viral infection. As a lead site for the on-going Phase II trial of JX-594 for liver cancer, we look forward to extending these results in a larger number of patients," said Dr. Tony Reid, M.D., Ph.D., Associate Professor and Director of Clinical Investigation at the University of California, San Diego Moores
'/>"/>

SOURCE Jennerex, Inc.
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3 4

Related medicine technology :

1. Jennerex Publishes Promising Results from Cancer Clinical Trial of JX-594 in Lancet Oncology
2. Jennerex Presents Clinical Data From JX-594 Demonstrating Tumor Efficacy Against Advanced Liver Cancers
3. Journal of Clinical Oncology Publishes Study of Cephalon Medication TREANDA Plus Rituximab in Relapsed Non-Hodgkins Lymphoma
4. Journal of Clinical Oncology Publishes Leukine(R) Study Demonstrating Positive Survival Outcomes in Patients with High-Risk Melanoma
5. The New England Journal of Medicine Publishes Study Investigating the Safety and Efficacy of Baxters Cell-Based Pandemic, Avian Flu Vaccine
6. New England Journal of Medicine Publishes Results From a RELISTOR Phase 3 Clinical Study
7. Video: The Journal, Human Genetics, Publishes Results Supporting Interleukin Genetics Heart Health Test
8. ImQuest Publishes Results of Important Structure Activity Relationship Program on Dual Acting Pyrimidinediones
9. Circulation Publishes Data Showing KYNAPID(TM) (Vernakalant Hydrochloride) Injection Rapidly Converted Short-Duration Atrial Fibrillation to Sinus Rhythm
10. Franklin & Seidelmann Publishes Complex Podiatry MRI Study
11. Biological Psychiatry Publishes Study Showing VYVANSE Demonstrated Significant Efficacy for Treatment of ADHD for up to 12 Hours After Administration
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/27/2014)... SALT LAKE CITY , Aug. 27, 2014 ... that will expand its current Salt Lake City ... operations currently underway outside of Utah ... state over the next 20 years. " ... immense engineering and technical talent, many of whom can be ...
(Date:8/27/2014)... 27, 2014 Decision Resources Group finds that ... Memphis health system and hospital sector ... with rivals Methodist Le Bonheur Healthcare and Baptist Memorial ... coordinate patient care. In addition, a national contract recently ... health plan enrollment in the Memphis ...
(Date:8/27/2014)... 27, 2014 ISPE , the International ... released a preview of its Drug Shortages Prevention ... drug shortages and maintain a robust and reliable supply ... Plan, a first for the industry, was developed by ... and describes how industry can best prevent drug shortages ...
Breaking Medicine Technology:Varian Medical Systems Groundbreaking on Facility Expansion Triggers Influx of New Jobs to Salt Lake 2Varian Medical Systems Groundbreaking on Facility Expansion Triggers Influx of New Jobs to Salt Lake 3Varian Medical Systems Groundbreaking on Facility Expansion Triggers Influx of New Jobs to Salt Lake 4Memphis-area Health Systems Turn Attention to Clinical Integration 2ISPE Releases First Look at its Plan to Prevent Drug Shortages 2ISPE Releases First Look at its Plan to Prevent Drug Shortages 3ISPE Releases First Look at its Plan to Prevent Drug Shortages 4
... MTD ) today announced it will host a ... November 4, 2010 at 5:00 p.m. Eastern Time. To hear ... on the Company,s website. A replay of the webcast will ... TOLEDO is a leading global supplier of precision instruments and ...
... WEST PALM BEACH, Fla., Oct. 28 The ... pain is where it all begins.  Lasting for ... rest, time and medication.  For many, that is ... converts to chronic pain, and new methods must ...
Cached Medicine Technology:Technology, New Therapies Reduce Use of Addictive Prescriptions 2
(Date:8/28/2014)... Texas (PRWEB) August 28, 2014 MMAR ... The program is a chance for regular customers to ... Medical without the need for a wholesale license. It’s ... coaches, semi-professional athletic programs and others who regularly purchase ... , “Whether supporting your own active lifestyle or ...
(Date:8/28/2014)... Loudoun County, VA (PRWEB) August 28, 2014 ... secure software development, today announced that it has ... awarded 10/22/2013 with the performance start date of ... the Department of Homeland Security (DHS) agency that ... Under the contract, Coveros and InfoZen will automate ...
(Date:8/28/2014)... Fort Worth, Texas (PRWEB) August 28, 2014 ... experiencing significant growth over the past few years. The new ... - will offer higher quality and larger office space than ... for growth. , “We are pleased about our new ... Laurenzo said. “While our suite will be double in size ...
(Date:8/28/2014)... (PRWEB) August 28, 2014 UniVoIP, Inc, ... El Segundo, CA, today announced that they have been ... of Los Angeles Local Small Business Enterprise (Local SBE) ... and certified by the state of California and LA ... Cloud-hosted Telephony Solution to governmental agencies throughout ...
(Date:8/27/2014)... Aeroflow Healthcare has announced it ... of a strategic expansion of its durable medical ... ownership of new businesses through additional resources and ... , Last week, the company announced that it ... increase service in the High Point/Greensboro/Winston-Salem area. This ...
Breaking Medicine News(10 mins):Health News:MMAR Medical Announces Customer Membership Program 2Health News:Coveros Partners with InfoZen on USCIS Transformation Integration Award 2Health News:Cloud PBX Provider UniVoIP Gets Certified by the State of California and the County of Los Angeles Under the Local Small Business Enterprise (SBE) Preference Program 2Health News:Aeroflow Healthcare Seeks Strategic Acquisition Opportunities 2
... Applications Now Available for the 2008-2009 Academic ... American,Association of Colleges of Nursing (AACN) is ... have been selected to receive The California,Endowment-AACN ... program was developed to provide financial support, ...
... Governor Edward G.,Rendell today said the Pennsylvania Children,s ... at specific Rite Aid,stores in south central Pennsylvania on ... "We,re working hard to make sure every parent understands ... be covered by CHIP," Governor,Rendell said. "Through Cover All ...
... 18 Oakwood Southshore,Medical Center (OSMC) is one ... a generous gift from Anthony J. Pellegrino. Pellegrino,donated ... "The Southshore Promise is really our pledge ... Oakwood Southshore,Medical Center. "We are in the business ...
... Impact on ... Meth Use in Montana, PALO ALTO, Calif., Sept. ... of the,United States Senate today. Siebel was invited to brief the panel ... Montana --,where the Meth Project implemented its first statewide program. Since the,launch ...
... Collins Industries, a,leading manufacturer of specialty vehicles in ... Bus, Inc. production facility in Bluffton,Ohio. Company officials plan ... in South Hutchinson, Kansas by November 9, 2007. ... Bluffton, Ohio was,certainly a difficult decision. Since the purchase ...
... 150,children,s hospital CEOs, medical directors, trustees and other ... to,Capitol Hill on Wednesday, September 19 to call ... (SCHIP). At noon at the Retired,Officers Association Building, ... (D-MT) and Sherrod Brown (D-OH) on the state ...
Cached Medicine News:Health News:Eight Graduate Nursing Students Selected to Receive The California Endowment-AACN Minority Nurse Faculty Scholarship 2Health News:Eight Graduate Nursing Students Selected to Receive The California Endowment-AACN Minority Nurse Faculty Scholarship 3Health News:Eight Graduate Nursing Students Selected to Receive The California Endowment-AACN Minority Nurse Faculty Scholarship 4Health News:Governor Rendell Announces CHIP Enrollment Clinics at Several Rite Aid Stores 2Health News:$1 Million Gift Boosts Downriver Community 2Health News:Meth Project Chairman Testifies Before U.S. Senate Finance Committee 2Health News:Meth Project Chairman Testifies Before U.S. Senate Finance Committee 3Health News:Company Announces Closure of Bluffton, Ohio Plant 2Health News:Children's Hospitals in Washington to Lobby Congress to Reauthorize SCHIP Now 2
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
Medicine Products: